Statistical Analysis of in Vivo Anticancer Experiments: Tumor Growth Inhibition

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  • Ludwig A. Hothorn

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OriginalspracheEnglisch
Seiten (von - bis)229-238
Seitenumfang10
FachzeitschriftTherapeutic Innovation & Regulatory Science
Jahrgang40
Ausgabenummer2
PublikationsstatusVeröffentlicht - 30 Dez. 2006

Abstract

Tumor growth inhibition data in in vivo anticancer experiments are commonly analyzed using the treatment-to-control ratio (TCR). Parametric and nonparametric confidence interval approaches for this ratio are introduced, enabling a quantitative statistical decision. The growth curves are characterized by the area-under-the-curve technique, adjusted for animal-specific survival. Simple simultaneous approaches are proposed for complex designs, including several treatment or dose groups. This implementation makes decision making easier for the pharmacologists through the use of simple diagrams for the treatment-to-control ratios and their confidence intervals. Tumor inhibition and regression can be appropriately statistically analyzed by treatment-to-control ratios and their confidence intervals.

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Statistical Analysis of in Vivo Anticancer Experiments: Tumor Growth Inhibition. / Hothorn, Ludwig A.
in: Therapeutic Innovation & Regulatory Science, Jahrgang 40, Nr. 2, 30.12.2006, S. 229-238.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Hothorn LA. Statistical Analysis of in Vivo Anticancer Experiments: Tumor Growth Inhibition. Therapeutic Innovation & Regulatory Science. 2006 Dez 30;40(2):229-238. doi: 10.1177/009286150604000212, https://doi.org/10.15488/3051
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