TY - JOUR

T1 - Risk-Taking Behavior of Adolescents and Young Adults Born Preterm

AU - Alenius, Suvi

AU - Kajantie, Eero

AU - Sund, Reijo

AU - Nurhonen, Markku

AU - Haaramo, Peija

AU - Näsänen-Gilmore, Pieta

AU - Vääräsmäki, Marja

AU - Lemola, Sakari

AU - Räikkönen, Katri

AU - Schnitzlein, Daniel D.

AU - Wolke, Dieter

AU - Gissler, Mika

AU - Hovi, Petteri

N1 - Funding Information: Supported by the Academy of Finland (Skidi-Kids program for 2010-2013 and grants 127437 , 129306 , 130326 , 134791 , 263924 , 274794 , 315690 [to E.K.]); and the Academy of Finland (Clinical Researcher Grant 288966 [to P.Ho.]); the Academy of Finland (grant number 1324596 [to K.R.]); European Commission (Horizon 2020 award RECAP Research on Children and Adults Born Preterm grant number 733280 [to E.K., K.R., D.W.]); the Doctoral Programs of Public Health, University of Helsinki [to S.A.]; the Finnish Foundation for Pediatric Research [to E.K., P.Ho.], the Signe and Ane Gyllenberg Foundation [to S.A., E.K., P.Ho.]; the Alli Paasikivi Foundation [to P.Ho.]; the Sigrid Jusélius Foundation [to E.K.]; the Juho Vainio Foundation [to E.K., S.A.]; Norface DIAL Programme (project 462-16-040 Premlife Life Course Dynamics after Preterm Birth [to E.K., K.R., D.S., D.W., S.L.]); the Novo Nordisk Foundation [to E.K.]; the Finnish Foundation for Cardiovascular Research [to E.K., P.Ho.]; the Emil Aaltonen Foundation [to E.K., P.Ho.]; the Paulo Foundation [to S.A.]; the Finnish Medical Foundation [to S.A.]; and the Päivikki and Sakari Sohlberg Foundation [to S.A.]. The study funders had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; writing, preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Funding Information: Supported by the Academy of Finland (Skidi-Kids program for 2010-2013 and grants 127437, 129306, 130326, 134791, 263924, 274794, 315690 [to E.K.]); and the Academy of Finland (Clinical Researcher Grant 288966 [to P.Ho.]); the Academy of Finland (grant number 1324596 [to K.R.]); European Commission (Horizon 2020 award RECAP Research on Children and Adults Born Preterm grant number 733280 [to E.K., K.R., D.W.]); the Doctoral Programs of Public Health, University of Helsinki [to S.A.]; the Finnish Foundation for Pediatric Research [to E.K., P.Ho.], the Signe and Ane Gyllenberg Foundation [to S.A., E.K., P.Ho.]; the Alli Paasikivi Foundation [to P.Ho.]; the Sigrid Jusélius Foundation [to E.K.]; the Juho Vainio Foundation [to E.K., S.A.]; Norface DIAL Programme (project 462-16-040 Premlife Life Course Dynamics after Preterm Birth [to E.K., K.R., D.S., D.W., S.L.]); the Novo Nordisk Foundation [to E.K.]; the Finnish Foundation for Cardiovascular Research [to E.K., P.Ho.]; the Emil Aaltonen Foundation [to E.K., P.Ho.]; the Paulo Foundation [to S.A.]; the Finnish Medical Foundation [to S.A.]; and the Päivikki and Sakari Sohlberg Foundation [to S.A.]. The study funders had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; writing, preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

PY - 2023/2

Y1 - 2023/2

N2 - Objectives: To study sexually transmitted Chlamydia trachomatis infections (STCTs), teenage pregnancies, and payment defaults in individuals born preterm as proxies for engaging in risk-taking behavior. Study design: Our population-based register-linkage study included all 191 705 children alive at 10 years (8492 preterm [4.4%]) born without malformations in Finland between January 1987 and September 1990 as each mother's first child within the cohort. They were followed until young adulthood. We used Cox regression to assess the hazards of STCTs, teenage pregnancies, payment defaults, criminal offending, and substance abuse by gestational age. Gestational age was considered both as a continuous and categorical (extremely, very, moderately, late preterm, early term, post term, and full term as reference) exposure. Results: A linear dose-response relationship existed between gestational age and STCT and teenage pregnancy; adjusted hazard for STCT decreased by 1.6% (95% CI, 0.7%-2.6%), and for teenage pregnancy by 3.3% (95% CI, 1.9%-4.8%) per each week decrease in gestational age. Those born extremely preterm (23-27 completed weeks) had a 51% (95% CI, 31%-83%) lower risk for criminal offending than their full-term born counterparts, and those born very preterm (range, 28-31 weeks) had a 28% (95% CI, 7%-53%) higher hazard for payment defaults than those born at full term. Gestational age was not associated with substance abuse. Conclusions: The lower risk-taking that characterizes people born preterm seems to generalize to sexual and to some extent criminal behavior. Those born very preterm are, however, more likely to experience payment defaults.

AB - Objectives: To study sexually transmitted Chlamydia trachomatis infections (STCTs), teenage pregnancies, and payment defaults in individuals born preterm as proxies for engaging in risk-taking behavior. Study design: Our population-based register-linkage study included all 191 705 children alive at 10 years (8492 preterm [4.4%]) born without malformations in Finland between January 1987 and September 1990 as each mother's first child within the cohort. They were followed until young adulthood. We used Cox regression to assess the hazards of STCTs, teenage pregnancies, payment defaults, criminal offending, and substance abuse by gestational age. Gestational age was considered both as a continuous and categorical (extremely, very, moderately, late preterm, early term, post term, and full term as reference) exposure. Results: A linear dose-response relationship existed between gestational age and STCT and teenage pregnancy; adjusted hazard for STCT decreased by 1.6% (95% CI, 0.7%-2.6%), and for teenage pregnancy by 3.3% (95% CI, 1.9%-4.8%) per each week decrease in gestational age. Those born extremely preterm (23-27 completed weeks) had a 51% (95% CI, 31%-83%) lower risk for criminal offending than their full-term born counterparts, and those born very preterm (range, 28-31 weeks) had a 28% (95% CI, 7%-53%) higher hazard for payment defaults than those born at full term. Gestational age was not associated with substance abuse. Conclusions: The lower risk-taking that characterizes people born preterm seems to generalize to sexual and to some extent criminal behavior. Those born very preterm are, however, more likely to experience payment defaults.

KW - adolescent behavior

KW - Chlamydia trachomatis

KW - criminal offending

KW - payment default

KW - premature birth

KW - register study

KW - substance abuse

KW - teenage pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85141976686&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2022.09.032

DO - 10.1016/j.jpeds.2022.09.032

M3 - Article

C2 - 36179892

AN - SCOPUS:85141976686

VL - 253

SP - 135-143.e6

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -