Protocol designed subgroup analyses in multiarmed clinical trials: Multiplicity aspects

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • Egbert H.E. Biesheuvel
  • Ludwig A. Hothorn

Externe Organisationen

  • Organon International
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)663-673
Seitenumfang11
FachzeitschriftJournal of Biopharmaceutical Statistics
Jahrgang13
Ausgabenummer4
PublikationsstatusVeröffentlicht - 2003
Extern publiziertJa

Abstract

Subgroup analyses are quite common in clinical trials although the subgroup findings are usually presented without adjustment for the multiple analyses, which increases the chance of false positive findings. This paper is focused on the multiplicity aspects of subgroup analyses in multiarmed randomized clinical trials and provides some guidance to practitioners.

ASJC Scopus Sachgebiete

Zitieren

Protocol designed subgroup analyses in multiarmed clinical trials: Multiplicity aspects. / Biesheuvel, Egbert H.E.; Hothorn, Ludwig A.
in: Journal of Biopharmaceutical Statistics, Jahrgang 13, Nr. 4, 2003, S. 663-673.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Biesheuvel, Egbert H.E. ; Hothorn, Ludwig A. / Protocol designed subgroup analyses in multiarmed clinical trials : Multiplicity aspects. in: Journal of Biopharmaceutical Statistics. 2003 ; Jahrgang 13, Nr. 4. S. 663-673.
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