PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Jean Baptiste Masclef
  • Emmanuelle M.N. Acs
  • Jesko Koehnke
  • Joëlle Prunet
  • Bernhard V.K.J. Schmidt

Organisationseinheiten

Externe Organisationen

  • University of Glasgow
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)6013–6023
Seitenumfang11
FachzeitschriftMACROMOLECULES
Jahrgang57
Ausgabenummer13
Frühes Online-Datum14 Juni 2024
PublikationsstatusVeröffentlicht - 9 Juli 2024

Abstract

Hydrophilic polymers have found ubiquitous use in drug delivery and novel polymer materials to advance drug delivery systems are highly sought after. Herein, an amylose mimic (PEGose) was combined with poly(lactic acid) (PLA) in an amphiphilic block copolymer to form PEG-free nanoparticles as an alternative to PEG-based nanomedicines. The block copolymer self-assembled into 150-200 nm particles with a narrow dispersity in aqueous environment. The formed nanoparticles were capable of encapsulation, the sustained release of both hydrophilic and hydrophobic dyes. Moreover, the nanoparticles were found to be remarkably stable and had a very low cytotoxicity and a high propensity to penetrate cells. These results highlight the potential of PEGose-b-PLA to be used in drug delivery with a new hydrophilic building block.

ASJC Scopus Sachgebiete

Zitieren

PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery. / Masclef, Jean Baptiste; Acs, Emmanuelle M.N.; Koehnke, Jesko et al.
in: MACROMOLECULES, Jahrgang 57, Nr. 13, 09.07.2024, S. 6013–6023.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Masclef, JB, Acs, EMN, Koehnke, J, Prunet, J & Schmidt, BVKJ 2024, 'PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery', MACROMOLECULES, Jg. 57, Nr. 13, S. 6013–6023. https://doi.org/10.1021/acs.macromol.4c00528
Masclef, J. B., Acs, E. M. N., Koehnke, J., Prunet, J., & Schmidt, B. V. K. J. (2024). PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery. MACROMOLECULES, 57(13), 6013–6023. https://doi.org/10.1021/acs.macromol.4c00528
Masclef JB, Acs EMN, Koehnke J, Prunet J, Schmidt BVKJ. PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery. MACROMOLECULES. 2024 Jul 9;57(13):6013–6023. Epub 2024 Jun 14. doi: 10.1021/acs.macromol.4c00528
Masclef, Jean Baptiste ; Acs, Emmanuelle M.N. ; Koehnke, Jesko et al. / PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery. in: MACROMOLECULES. 2024 ; Jahrgang 57, Nr. 13. S. 6013–6023.
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AU - Masclef, Jean Baptiste

AU - Acs, Emmanuelle M.N.

AU - Koehnke, Jesko

AU - Prunet, Joëlle

AU - Schmidt, Bernhard V.K.J.

N1 - Publisher Copyright: © 2024 The Authors. Published by American Chemical Society.

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