Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 801-808 |
| Seitenumfang | 8 |
| Fachzeitschrift | Acta oto-laryngologica |
| Jahrgang | 127 |
| Ausgabenummer | 8 |
| Publikationsstatus | Veröffentlicht - 23 Juni 2006 |
Abstract
Conclusion. The improved biocompatibility of Bioverit® II coated with a nanostructured surface shows promising qualities for use in human reconstructive middle ear surgery. In the case of chitosan-hydroxyapatite composite prostheses, further investigations regarding composition of the material, degree of purity and design are necessary before clinical application. Objective. The selection of optimal materials for reconstructive middle ear surgery continues to be a problem. In the present study novel materials were tested as total ossicular replacement prostheses (TORPs) in an animal model. Materials and methods. Bioverit® II coated with a nanostructured surface and chitosan-hydroxyapatite composites were placed in the middle ear of 40 rabbits. Uncoated Bioverit® II was used as control. After an implantation period of 28, 84 or 300 days petrous bones were extracted, embedded in epoxy resin and examined by light microscopy. Results. Uncoated and coated Bioverit® prostheses revealed a mucosal coverage and a little osseogenic response after 28 days. The results of the coated Bioverit® prostheses slightly surpassed those of the plain prostheses. Chitosan-hydroxyapatite composite prostheses were mostly found to be dislocated after 28 days. Formations of granulation tissue and fibrotic capsules were observed around these implants. This reaction could be caused by the instability of the composite material or may be due to impurities present in the chitosan.
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Hals-Nasen-Ohrenheilkunde
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in: Acta oto-laryngologica, Jahrgang 127, Nr. 8, 23.06.2006, S. 801-808.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Histological evaluation of novel ossicular chain replacement prostheses
T2 - An animal study in rabbits
AU - Turck, Christina
AU - Brandes, Gudrun
AU - Krüger, Ilka
AU - Behrens, Peter
AU - Mojallal, Hamidreza
AU - Lenarz, Thomas
AU - Stieve, Martin
N1 - Funding information: The authors would like to express their gratitude to PD Dr K. Esser, Department of Zoology, University of Veterinary Medicine Hannover, for his supervision of this work, as well as to P. Erfurt and N. Trabandt for their helpful information regarding the histological preparation. This project is supported by the DFG within the Collaborative Research Centre SFB 599 (work package D1). We acknowledge valuable discussions with PD Dr P.P. Müller, Gesellschaft für Biotechnologische Forschung, Braunschweig.
PY - 2006/6/23
Y1 - 2006/6/23
N2 - Conclusion. The improved biocompatibility of Bioverit® II coated with a nanostructured surface shows promising qualities for use in human reconstructive middle ear surgery. In the case of chitosan-hydroxyapatite composite prostheses, further investigations regarding composition of the material, degree of purity and design are necessary before clinical application. Objective. The selection of optimal materials for reconstructive middle ear surgery continues to be a problem. In the present study novel materials were tested as total ossicular replacement prostheses (TORPs) in an animal model. Materials and methods. Bioverit® II coated with a nanostructured surface and chitosan-hydroxyapatite composites were placed in the middle ear of 40 rabbits. Uncoated Bioverit® II was used as control. After an implantation period of 28, 84 or 300 days petrous bones were extracted, embedded in epoxy resin and examined by light microscopy. Results. Uncoated and coated Bioverit® prostheses revealed a mucosal coverage and a little osseogenic response after 28 days. The results of the coated Bioverit® prostheses slightly surpassed those of the plain prostheses. Chitosan-hydroxyapatite composite prostheses were mostly found to be dislocated after 28 days. Formations of granulation tissue and fibrotic capsules were observed around these implants. This reaction could be caused by the instability of the composite material or may be due to impurities present in the chitosan.
AB - Conclusion. The improved biocompatibility of Bioverit® II coated with a nanostructured surface shows promising qualities for use in human reconstructive middle ear surgery. In the case of chitosan-hydroxyapatite composite prostheses, further investigations regarding composition of the material, degree of purity and design are necessary before clinical application. Objective. The selection of optimal materials for reconstructive middle ear surgery continues to be a problem. In the present study novel materials were tested as total ossicular replacement prostheses (TORPs) in an animal model. Materials and methods. Bioverit® II coated with a nanostructured surface and chitosan-hydroxyapatite composites were placed in the middle ear of 40 rabbits. Uncoated Bioverit® II was used as control. After an implantation period of 28, 84 or 300 days petrous bones were extracted, embedded in epoxy resin and examined by light microscopy. Results. Uncoated and coated Bioverit® prostheses revealed a mucosal coverage and a little osseogenic response after 28 days. The results of the coated Bioverit® prostheses slightly surpassed those of the plain prostheses. Chitosan-hydroxyapatite composite prostheses were mostly found to be dislocated after 28 days. Formations of granulation tissue and fibrotic capsules were observed around these implants. This reaction could be caused by the instability of the composite material or may be due to impurities present in the chitosan.
KW - Biocompatibility
KW - Bioverit®
KW - Chitosan
KW - Hydroxyapatite
KW - Middle ear
KW - Nanostructure
KW - Rabbit
KW - TORP
UR - http://www.scopus.com/inward/record.url?scp=34548359416&partnerID=8YFLogxK
U2 - 10.1080/00016480601053032
DO - 10.1080/00016480601053032
M3 - Article
C2 - 17729180
AN - SCOPUS:34548359416
VL - 127
SP - 801
EP - 808
JO - Acta oto-laryngologica
JF - Acta oto-laryngologica
SN - 0001-6489
IS - 8
ER -