Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 151265 |
| Fachzeitschrift | Tetrahedron Letters |
| Jahrgang | 60 |
| Ausgabenummer | 46 |
| Frühes Online-Datum | 15 Okt. 2019 |
| Publikationsstatus | Veröffentlicht - 14 Nov. 2019 |
Abstract
Herein, we report the first synthesis of 10b-azachrysenes via the Hantzsch-like reaction of aldehydes with 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile and dimedone in the presence of acetic acid. The regioselectivity was established using X-ray crystallography and 2D-HMBC spectroscopy.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Wirkstoffforschung
- Chemie (insg.)
- Organische Chemie
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in: Tetrahedron Letters, Jahrgang 60, Nr. 46, 151265, 14.11.2019.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Hantzsch-like three-component synthesis of tetracyclic 10b-azachrysenes
T2 - Unambiguous structural elucidation using X-ray crystallography and 2D-HMBC spectroscopy
AU - Saleh, Fatma M.
AU - Hassaneen, Hamdi M.
AU - Butenschön, Holger
AU - Dräger, Gerald
AU - Abdelhamid, Ismail A.
PY - 2019/11/14
Y1 - 2019/11/14
N2 - Herein, we report the first synthesis of 10b-azachrysenes via the Hantzsch-like reaction of aldehydes with 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile and dimedone in the presence of acetic acid. The regioselectivity was established using X-ray crystallography and 2D-HMBC spectroscopy.
AB - Herein, we report the first synthesis of 10b-azachrysenes via the Hantzsch-like reaction of aldehydes with 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile and dimedone in the presence of acetic acid. The regioselectivity was established using X-ray crystallography and 2D-HMBC spectroscopy.
KW - 2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile
KW - Hantzsch-like reaction
KW - Hexahydro-10b-azachrysene
KW - X-ray crystallography
UR - http://www.scopus.com/inward/record.url?scp=85073752729&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2019.151265
DO - 10.1016/j.tetlet.2019.151265
M3 - Article
AN - SCOPUS:85073752729
VL - 60
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 46
M1 - 151265
ER -