Cyclodextrin-functionalized asymmetric block copolymer films as high-capacity reservoir for drug delivery

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Tiefan Huang
  • Priyanka Manchanda
  • Liwen Zhang
  • Osama Shekhah
  • Niveen M. Khashab
  • Mohamed Eddaoudi
  • Klaus Viktor Peinemann

Externe Organisationen

  • King Abdullah University of Science and Technology (KAUST)
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Details

OriginalspracheEnglisch
Seiten (von - bis)1-8
Seitenumfang8
FachzeitschriftJournal of membrane science
Jahrgang584
PublikationsstatusVeröffentlicht - 15 Aug. 2019
Extern publiziertJa

Abstract

Asymmetric block copolymer membranes can be facilely prepared via non-solvent induced phase separation combined with self-assembly. The membrane is characterized by a thin layer of highly ordered and uniform cylindrical nano-channels on top of a non-ordered macroporous sponge-like layer. Up to date, most studies concerning block copolymer membranes are focused on separation applications. In this work, highly adsorptive and adhesive isoporous block copolymer membranes have been fabricated. Because of the functionalization with cyclodextrin, the membrane shows excellent affinity to guest molecules. Moreover, the membrane is biocompatible and is adhesive to various substrates (e.g. glass, silicon, gold and stainless steel). Triclosan as a model drug was utilized to demonstrate the applicability of the membranes as a drug reservoir. A high loading capacity (305.5 μg cm−2) was achieved. The release behavior was investigated under various pH values in vitro. A long-time extended drug release was achieved without showing an initial burst effect. Furthermore, pH-responsive release behavior was observed. The triclosan-loaded membrane exhibited a significant antibacterial effect due to the triclosan release; the diffusion out of the membrane was evaluated using a disc diffusion assay. This study provides great potential for isoporous block copolymer membranes as a delivery platform for a wide variety of biomedical applications.

ASJC Scopus Sachgebiete

Zitieren

Cyclodextrin-functionalized asymmetric block copolymer films as high-capacity reservoir for drug delivery. / Huang, Tiefan; Manchanda, Priyanka; Zhang, Liwen et al.
in: Journal of membrane science, Jahrgang 584, 15.08.2019, S. 1-8.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Huang, T., Manchanda, P., Zhang, L., Shekhah, O., Khashab, N. M., Eddaoudi, M., & Peinemann, K. V. (2019). Cyclodextrin-functionalized asymmetric block copolymer films as high-capacity reservoir for drug delivery. Journal of membrane science, 584, 1-8. https://doi.org/10.1016/j.memsci.2019.04.039
Huang T, Manchanda P, Zhang L, Shekhah O, Khashab NM, Eddaoudi M et al. Cyclodextrin-functionalized asymmetric block copolymer films as high-capacity reservoir for drug delivery. Journal of membrane science. 2019 Aug 15;584:1-8. doi: 10.1016/j.memsci.2019.04.039
Huang, Tiefan ; Manchanda, Priyanka ; Zhang, Liwen et al. / Cyclodextrin-functionalized asymmetric block copolymer films as high-capacity reservoir for drug delivery. in: Journal of membrane science. 2019 ; Jahrgang 584. S. 1-8.
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title = "Cyclodextrin-functionalized asymmetric block copolymer films as high-capacity reservoir for drug delivery",
abstract = "Asymmetric block copolymer membranes can be facilely prepared via non-solvent induced phase separation combined with self-assembly. The membrane is characterized by a thin layer of highly ordered and uniform cylindrical nano-channels on top of a non-ordered macroporous sponge-like layer. Up to date, most studies concerning block copolymer membranes are focused on separation applications. In this work, highly adsorptive and adhesive isoporous block copolymer membranes have been fabricated. Because of the functionalization with cyclodextrin, the membrane shows excellent affinity to guest molecules. Moreover, the membrane is biocompatible and is adhesive to various substrates (e.g. glass, silicon, gold and stainless steel). Triclosan as a model drug was utilized to demonstrate the applicability of the membranes as a drug reservoir. A high loading capacity (305.5 μg cm−2) was achieved. The release behavior was investigated under various pH values in vitro. A long-time extended drug release was achieved without showing an initial burst effect. Furthermore, pH-responsive release behavior was observed. The triclosan-loaded membrane exhibited a significant antibacterial effect due to the triclosan release; the diffusion out of the membrane was evaluated using a disc diffusion assay. This study provides great potential for isoporous block copolymer membranes as a delivery platform for a wide variety of biomedical applications.",
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Download

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T1 - Cyclodextrin-functionalized asymmetric block copolymer films as high-capacity reservoir for drug delivery

AU - Huang, Tiefan

AU - Manchanda, Priyanka

AU - Zhang, Liwen

AU - Shekhah, Osama

AU - Khashab, Niveen M.

AU - Eddaoudi, Mohamed

AU - Peinemann, Klaus Viktor

N1 - Funding Information: The authors gratefully acknowledge financial support from King Abdullah University of Science and Technology ( KAUST ).

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Asymmetric block copolymer membranes can be facilely prepared via non-solvent induced phase separation combined with self-assembly. The membrane is characterized by a thin layer of highly ordered and uniform cylindrical nano-channels on top of a non-ordered macroporous sponge-like layer. Up to date, most studies concerning block copolymer membranes are focused on separation applications. In this work, highly adsorptive and adhesive isoporous block copolymer membranes have been fabricated. Because of the functionalization with cyclodextrin, the membrane shows excellent affinity to guest molecules. Moreover, the membrane is biocompatible and is adhesive to various substrates (e.g. glass, silicon, gold and stainless steel). Triclosan as a model drug was utilized to demonstrate the applicability of the membranes as a drug reservoir. A high loading capacity (305.5 μg cm−2) was achieved. The release behavior was investigated under various pH values in vitro. A long-time extended drug release was achieved without showing an initial burst effect. Furthermore, pH-responsive release behavior was observed. The triclosan-loaded membrane exhibited a significant antibacterial effect due to the triclosan release; the diffusion out of the membrane was evaluated using a disc diffusion assay. This study provides great potential for isoporous block copolymer membranes as a delivery platform for a wide variety of biomedical applications.

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