A Core Module of Nuclear Genes Regulated by Biogenic Retrograde Signals from Plastids

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OriginalspracheEnglisch
Aufsatznummer296
Seitenumfang20
FachzeitschriftPlants
Jahrgang10
Ausgabenummer2
PublikationsstatusVeröffentlicht - 4 Feb. 2021

Abstract

Chloroplast biogenesis during seedling development of angiosperms is a rapid and highly dynamic process that parallels the light-dependent photomorphogenic programme. Pre-treatments of dark-grown seedlings with lincomyin or norflurazon prevent chloroplast biogenesis upon illumination yielding albino seedlings. A comparable phenotype was found for the Arabidopsis mutant plastid-encoded polymerase associated protein 7 (pap7) being defective in the prokaryotic-type plastid RNA polymerase. In all three cases the defect in plastid function has a severe impact on the expression of nuclear genes representing the influence of retrograde signaling pathway(s) from the plastid. We performed a meta-analysis of recently published genome-wide expression studies that investigated the impact of the aforementioned chemical and genetic blocking of chloroplast biogenesis on nuclear gene expression profiles. We identified a core module of 152 genes being affected in all three conditions. These genes were classified according to their function and analyzed with respect to their implication in retrograde signaling and chloroplast biogenesis. Our study uncovers novel genes regulated by retrograde biogenic signals and suggests the action of a common signaling pathway that is used by signals originating from plastid transcription, translation and oxidative stress.

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A Core Module of Nuclear Genes Regulated by Biogenic Retrograde Signals from Plastids. / Grübler, Björn; Cozzi, Carolina; Pfannschmidt, Thomas.
in: Plants, Jahrgang 10, Nr. 2, 296, 04.02.2021.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Grübler B, Cozzi C, Pfannschmidt T. A Core Module of Nuclear Genes Regulated by Biogenic Retrograde Signals from Plastids. Plants. 2021 Feb 4;10(2):296. doi: 10.3390/plants10020296
Grübler, Björn ; Cozzi, Carolina ; Pfannschmidt, Thomas. / A Core Module of Nuclear Genes Regulated by Biogenic Retrograde Signals from Plastids. in: Plants. 2021 ; Jahrgang 10, Nr. 2.
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abstract = "Chloroplast biogenesis during seedling development of angiosperms is a rapid and highly dynamic process that parallels the light-dependent photomorphogenic programme. Pre-treatments of dark-grown seedlings with lincomyin or norflurazon prevent chloroplast biogenesis upon illumination yielding albino seedlings. A comparable phenotype was found for the Arabidopsis mutant plastid-encoded polymerase associated protein 7 (pap7) being defective in the prokaryotic-type plastid RNA polymerase. In all three cases the defect in plastid function has a severe impact on the expression of nuclear genes representing the influence of retrograde signaling pathway(s) from the plastid. We performed a meta-analysis of recently published genome-wide expression studies that investigated the impact of the aforementioned chemical and genetic blocking of chloroplast biogenesis on nuclear gene expression profiles. We identified a core module of 152 genes being affected in all three conditions. These genes were classified according to their function and analyzed with respect to their implication in retrograde signaling and chloroplast biogenesis. Our study uncovers novel genes regulated by retrograde biogenic signals and suggests the action of a common signaling pathway that is used by signals originating from plastid transcription, translation and oxidative stress.",
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TY - JOUR

T1 - A Core Module of Nuclear Genes Regulated by Biogenic Retrograde Signals from Plastids

AU - Grübler, Björn

AU - Cozzi, Carolina

AU - Pfannschmidt, Thomas

PY - 2021/2/4

Y1 - 2021/2/4

N2 - Chloroplast biogenesis during seedling development of angiosperms is a rapid and highly dynamic process that parallels the light-dependent photomorphogenic programme. Pre-treatments of dark-grown seedlings with lincomyin or norflurazon prevent chloroplast biogenesis upon illumination yielding albino seedlings. A comparable phenotype was found for the Arabidopsis mutant plastid-encoded polymerase associated protein 7 (pap7) being defective in the prokaryotic-type plastid RNA polymerase. In all three cases the defect in plastid function has a severe impact on the expression of nuclear genes representing the influence of retrograde signaling pathway(s) from the plastid. We performed a meta-analysis of recently published genome-wide expression studies that investigated the impact of the aforementioned chemical and genetic blocking of chloroplast biogenesis on nuclear gene expression profiles. We identified a core module of 152 genes being affected in all three conditions. These genes were classified according to their function and analyzed with respect to their implication in retrograde signaling and chloroplast biogenesis. Our study uncovers novel genes regulated by retrograde biogenic signals and suggests the action of a common signaling pathway that is used by signals originating from plastid transcription, translation and oxidative stress.

AB - Chloroplast biogenesis during seedling development of angiosperms is a rapid and highly dynamic process that parallels the light-dependent photomorphogenic programme. Pre-treatments of dark-grown seedlings with lincomyin or norflurazon prevent chloroplast biogenesis upon illumination yielding albino seedlings. A comparable phenotype was found for the Arabidopsis mutant plastid-encoded polymerase associated protein 7 (pap7) being defective in the prokaryotic-type plastid RNA polymerase. In all three cases the defect in plastid function has a severe impact on the expression of nuclear genes representing the influence of retrograde signaling pathway(s) from the plastid. We performed a meta-analysis of recently published genome-wide expression studies that investigated the impact of the aforementioned chemical and genetic blocking of chloroplast biogenesis on nuclear gene expression profiles. We identified a core module of 152 genes being affected in all three conditions. These genes were classified according to their function and analyzed with respect to their implication in retrograde signaling and chloroplast biogenesis. Our study uncovers novel genes regulated by retrograde biogenic signals and suggests the action of a common signaling pathway that is used by signals originating from plastid transcription, translation and oxidative stress.

KW - Biogenic signals

KW - Lincomycin

KW - Norflurazon

KW - Pap7-1 mutant

KW - Photomorphogenesis

KW - Plastids

KW - Retrograde control

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U2 - 10.3390/plants10020296

DO - 10.3390/plants10020296

M3 - Article

C2 - 33557197

VL - 10

JO - Plants

JF - Plants

SN - 2223-7747

IS - 2

M1 - 296

ER -

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