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Prof. Dr.  Thomas Scheper

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Publications

  1. 2024

  2. Published

    Enhancing chemotherapeutic efficacy: Niosome-encapsulated Dox-Cis with MUC-1 aptamer

    Barlas, F. B., Olceroglu, B., Ag Seleci, D., Gumus, Z. P., Siyah, P., Dabbek, M., Garnweitne, G., Stahl, F., Scheper, T. & Timur, S., 9 Aug 2024, In: Cancer medicine. 13, 15, 10 p., e70079.

    Research output: Contribution to journalArticleResearchpeer review

  3. Published

    A Novel Artificial Coronary Plaque to Model Coronary Heart Disease

    Lindenhahn, P., Richter, J., Pepelanova, I., Seeger, B., Volk, H. A., Hinkel, R., Hiebl, B., Scheper, T., Hinrichs, J. B., Becker, L. S., Haverich, A. & Kaufeld, T., 26 Mar 2024, In: Biomimetics. 9, 4, 15 p., 197.

    Research output: Contribution to journalArticleResearchpeer review

  4. 2023

  5. Published

    Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

    Heuer, C., Jiang, X., Ron, G., Ternyak, O., Scheper, T., Bahnemann, J. & Segal, E., 27 Dec 2023, In: Chemical communications. 60, 10, p. 1305-1308 4 p.

    Research output: Contribution to journalArticleResearchpeer review

  6. Published

    Establishment of a Perfusion Process with Antibody-Producing CHO Cells Using a 3D-Printed Microfluidic Spiral Separator with Web-Based Flow Control

    Schellenberg, J., Dehne, M., Lange, F., Scheper, T., Solle, D. & Bahnemann, J., Jun 2023, In: Bioengineering. 10, 6, 656.

    Research output: Contribution to journalArticleResearchpeer review

  7. Published

    Digitale Zwillinge in der Bioprozesstechnik – Chancen und Möglichkeiten

    RIchter, J., Lange, F., Scheper, T., Solle, D. & Beutel, S., 22 Mar 2023, In: Chemie-Ingenieur-Technik. 95, 4, p. 498-510 13 p.

    Research output: Contribution to journalArticleResearch

  8. Published

    Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibodies

    Wohlenberg, O. J., Kortmann, C., Meyer, K. V., Scheper, T. & Solle, D., 2 Feb 2023, In: Engineering in life sciences. 23, 2, e202200056.

    Research output: Contribution to journalArticleResearchpeer review

  9. 2022

  10. Published

    A 3D-printed microfluidic gradient generator with integrated photonic silicon sensors for rapid antimicrobial susceptibility testing

    Heuer, C., Preuss, J. A., Buttkewitz, M., Scheper, T., Segal, E. & Bahnemann, J., 22 Nov 2022, In: LAB on a chip. 22, 24, p. 4950-4961 12 p.

    Research output: Contribution to journalArticleResearchpeer review

  11. Published

    Peripheral blood derived endothelial colony forming cells as suitable cell source for pre-endothelialization of arterial vascular grafts under dynamic flow conditions

    Kraus, X., van de Flierdt, E., Renzelmann, J., Thoms, S., Witt, M., Scheper, T. & Blume, C., Sept 2022, In: Microvascular research. 143, 104402.

    Research output: Contribution to journalArticleResearchpeer review

  12. Published

    Optimization of a mAb production process with regard to robustness and product quality using quality by design principles

    Wohlenberg, O. J., Kortmann, C., Meyer, K. V., Schellenberg, J., Dahlmann, K., Bahnemann, J., Scheper, T. & Solle, D., Jul 2022, In: Engineering in life sciences. 22, 7, p. 484-494 11 p.

    Research output: Contribution to journalArticleResearchpeer review

  13. Published

    Green Synthesis of Silver Nanoparticles Using Hypericum perforatum L. Aqueous Extract with the Evaluation of Its Antibacterial Activity against Clinical and Food Pathogens

    Alahmad, A., Al-Zereini, W. A., Hijazin, T. J., Al-Madanat, O. Y., Alghoraibi, I., Al-Qaralleh, O., Al-Qaraleh, S., Feldhoff, A., Walter, J. G. & Scheper, T., May 2022, In: Pharmaceutics. 14, 5, 19 p., 1104.

    Research output: Contribution to journalArticleResearchpeer review

  14. Published

    Stress-induced increase of monoclonal antibody production in CHO cells

    Schellenberg, J., Nagraik, T., Wohlenberg, O. J., Ruhl, S., Bahnemann, J., Scheper, T. & Solle, D., May 2022, In: Engineering in life sciences. 22, 5, p. 427-436 10 p.

    Research output: Contribution to journalArticleResearchpeer review

  15. Published

    Identification of Major Constituents of Hypericum perforatum L. Extracts in Syria by Development of a Rapid, Simple, and Reproducible HPLC-ESI-Q-TOF MS Analysis and Their Antioxidant Activities

    Alahmad, A., Alghoraibi, I., Zein, R., Kraft, S., Dräger, G., Walter, J. G. & Scheper, T., 26 Apr 2022, In: ACS Omega. 7, 16, p. 13475-13493 19 p.

    Research output: Contribution to journalArticleResearchpeer review

  16. Published

    On-Line Monitoring of Biological Parameters in Microalgal Bioprocesses Using Optical Methods

    Havlik, I., Beutel, S., Scheper, T. & Reardon, K. F., 25 Jan 2022, In: Energies. 15, 3, 875.

    Research output: Contribution to journalReview articleResearchpeer review

  17. 2021

  18. Published

    Paving the Way to Overcome Antifungal Drug Resistance: Current Practices and Novel Developments for Rapid and Reliable Antifungal Susceptibility Testing

    Heuer, C., Bahnemann, J., Scheper, T. & Segal, E., 12 Nov 2021, In: Small Methods. 5, 11, 2100713.

    Research output: Contribution to journalReview articleResearchpeer review

  19. Published

    Porous Silicon-Based Aptasensors: Toward Cancer Protein Biomarker Detection

    Arshavsky-Graham, S., Ward, S. J., Massad-Ivanir, N., Scheper, T., Weiss, S. M. & Segal, E., 20 Oct 2021, In: ACS Measurement Science Au. 1, 2, p. 82-94 13 p.

    Research output: Contribution to journalArticleResearchpeer review

  20. Published

    Vascular Network Formation on Macroporous Polydioxanone Scaffolds

    Heene, S., Thoms, S., Kalies, S., Wegner, N., Peppermüller, P., Born, N., Walther, F., Scheper, T. & Blume, C. A., 18 Oct 2021, In: Tissue Engineering - Part A. 27, 19-20, p. 1239-1249 11 p.

    Research output: Contribution to journalArticleResearch

  21. Published

    Clinical applicability of optogenetic gene regulation

    Wichert, N., Witt, M., Blume, C. & Scheper, T., 13 Oct 2021, In: Biotechnology and bioengineering. 118, 11, p. 4168-4185 18 p.

    Research output: Contribution to journalReview articleResearchpeer review

  22. Published

    Refolding, purification, and characterization of constitutive-active human-Smad8 produced as inclusion bodies in ClearColi® BL21 (DE3)

    Segovia-Trinidad, C. L., Quaas, B., Li, Z., Lavrentieva, A., Roger, Y., Scheper, T., Hoffmann, A. & Rinas, U., Aug 2021, In: Protein Expression and Purification. 184, 105878.

    Research output: Contribution to journalArticleResearchpeer review

  23. Published

    Transferrin-decorated niosomes with integrated inp/zns quantum dots and magnetic iron oxide nanoparticles: Dual targeting and imaging of glioma

    Seleci, D. A., Maurer, V., Barlas, F. B., Porsiel, J. C., Temel, B., Ceylan, E., Timur, S., Stahl, F., Scheper, T. & Garnweitner, G., 1 May 2021, In: International Journal of Molecular Sciences. 22, 9, 4556.

    Research output: Contribution to journalArticleResearchpeer review

  24. Published

    Monitoring cell productivity for the production of recombinant proteins by flow cytometry: An effective application using the cold capture assay

    Meyer, K. V., Siller, I. G., Schellenberg, J., Gonzalez Salcedo, A., Solle, D., Matuszczyk, J., Scheper, T. & Bahnemann, J., May 2021, In: Engineering in life sciences. 21, 5, p. 288-293 6 p.

    Research output: Contribution to journalArticleResearchpeer review

  25. Published

    Implementation of QbD strategies in the inoculum expansion of a mAb production process

    Böhl, O. J., Schellenberg, J., Bahnemann, J., Hitzmann, B., Scheper, T. & Solle, D., 2 Mar 2021, In: Engineering in life sciences. 21, 3-4, p. 196-207 12 p.

    Research output: Contribution to journalArticleResearchpeer review

  26. Published

    Implementing a digital infrastructure for the lab using a central laboratory server and the SiLA2 communication standard

    Porr, M., Lange, F., Marquard, D., Niemeyer, L., Lindner, P., Scheper, T. & Beutel, S., 2 Mar 2021, In: Engineering in life sciences. 21, 3-4, p. 208-219 12 p.

    Research output: Contribution to journalArticleResearchpeer review

  27. Published

    A pre-conditioning protocol of peripheral blood derived endothelial colony forming cells for endothelialization of tissue engineered constructs

    Kraus, X., Pflaum, M., Thoms, S., Jonczyk, R., Witt, M., Scheper, T. & Blume, C., Mar 2021, In: Microvascular research. 134, 104107.

    Research output: Contribution to journalArticleResearchpeer review

  28. Published

    In-vitro application of magnetic hybrid niosomes: Targeted sirna-delivery for enhanced breast cancer therapy

    Maurer, V., Altin, S., Seleci, D. A., Zarinwall, A., Temel, B., Vogt, P. M., Strauß, S., Stahl, F., Scheper, T., Bucan, V. & Garnweitner, G., Mar 2021, In: Pharmaceutics. 13, 3, 394.

    Research output: Contribution to journalArticleResearchpeer review

  29. Published

    Hypericum perforatum L.-mediated green synthesis of silver nanoparticles exhibiting antioxidant and anticancer activities

    Alahmad, A., Feldhoff, A., Bigall, N. C., Rusch, P., Scheper, T. & Walter, J. G., 14 Feb 2021, In: Nanomaterials. 11, 2, p. 1-26 26 p., 487.

    Research output: Contribution to journalArticleResearchpeer review

  30. Published

    Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

    Kirsch, H. M., Rach, J., Handke, W., Seltsam, A., Pepelanova, I., Strauß, S., Vogt, P., Scheper, T. & Lavrentieva, A., 15 Jan 2021, In: Frontiers in Bioengineering and Biotechnology. 8, 598389.

    Research output: Contribution to journalArticleResearchpeer review

  31. 2020

  32. Published

    Whole-Cell Production of Patchouli Oil Sesquiterpenes in Escherichia coli: Metabolic Engineering and Fermentation Optimization in Solid-Liquid Phase Partitioning Cultivation

    Aguilar, F., Ekramzadeh, K., Scheper, T. & Beutel, S., 22 Dec 2020, In: ACS Omega. 5, 50, p. 32436-32446 11 p.

    Research output: Contribution to journalArticleResearchpeer review

  33. Published

    Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant Escherichia coli using high cell density cultivation

    Bartling, B., Brüchle, N. C., Rehfeld, J. S., Boßmann, D., Fiebig, T., Litschko, C., Fohrer, J., Gerardy-Schahn, R., Scheper, T. & Beutel, S., Dec 2020, In: Biotechnology Reports. 28, e00562.

    Research output: Contribution to journalArticleResearchpeer review

  34. Published

    Development of an Aptamer-Based Lateral Flow Assay for the Detection of C-Reactive Protein Using Microarray Technology as a Prescreening Platform

    Phung, N. L., Walter, J. G., Jonczyk, R., Seiler, L. K., Scheper, T. & Blume, C., 9 Nov 2020, In: ACS combinatorial science. 22, 11, p. 617-629 13 p.

    Research output: Contribution to journalArticleResearchpeer review

  35. Published

    Live reporting for hypoxia: Hypoxia sensor–modified mesenchymal stem cells as in vitro reporters

    Schmitz, C., Pepelanova, I., Seliktar, D., Potekhina, E., Belousov, V. V., Scheper, T. & Lavrentieva, A., 15 Oct 2020, In: Biotechnology and bioengineering. 117, 11, p. 3265-3276 12 p.

    Research output: Contribution to journalArticleResearchpeer review

  36. Published

    Antifungal Susceptibility Testing of Aspergillus Niger on Silicon Microwells by Intensity-Based Reflectometric Interference Spectroscopy

    Heuer, C., Leonard, H., Nitzan, N., Lavy-Alperovitch, A., Massad-Ivanir, N., Scheper, T. & Segal, E., 9 Oct 2020, In: ACS infectious diseases. 6, 10, p. 2560-2566 7 p.

    Research output: Contribution to journalArticleResearchpeer review

  37. Published

    Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes

    Schwarzbich, S., Horstmann Née Gruschka, C., Simon, J., Siebe, L., Moreth, A., Wiegand, C., Lavrentieva, A., Scheper, T., Stammler, A., Bögge, H., Fischer Von Mollard, G. & Glaser, T., 5 Oct 2020, In: Inorganic chemistry. 59, 19, p. 14464-14477 14 p.

    Research output: Contribution to journalArticleResearchpeer review

  38. Published

    Bringing IoT to the lab: sila2 and open-source-powered gateway module for integrating legacy devices into the digital laboratory

    Porr, M. J., Schwarz, S., Lange, F. H., Niemeyer, L., Hentrop, T., Marquard, D., Lindner, P., Scheper, T. & Beutel, S., Oct 2020, In: HardwareX. 8, e00118.

    Research output: Contribution to journalArticleResearchpeer review

  39. Published

    Customizable 3D-printed (Co-)cultivation systems for in vitro study of angiogenesis

    Siller, I. G., Epping, N. M., Lavrentieva, A., Scheper, T. & Bahnemann, J., 25 Sept 2020, In: MATERIALS. 13, 19, p. 1-17 17 p., 4290.

    Research output: Contribution to journalArticleResearchpeer review

  40. Published

    Digitalization and Bioprocessing: Promises and Challenges

    Scheper, T., Beutel, S., McGuinness, N., Heiden, S., Oldiges, M., Lammers, F. & Reardon, K. F., 1 Sept 2020, Digital Twins: Tools and Concepts for Smart Biomanufacturing. Herwig, C., Pörtner, R. & Möller, J. (eds.). 1 ed. Vol. 176. p. 57-69 13 p. (Advances in biochemical engineering/biotechnology).

    Research output: Chapter in book/report/conference proceedingContribution to book/anthologyResearchpeer review

  41. Published

    Purification of the human fibroblast growth factor 2 using novel animal-component free materials

    Bolten, S. N., Knoll, A. S., Li, Z., Gellermann, P., Pepelanova, I., Rinas, U. & Scheper, T., 30 Aug 2020, In: Journal of Chromatography A. 1626, 461367.

    Research output: Contribution to journalArticleResearchpeer review

  42. Published

    Biotechnologische Produktion von niedermolekularer Polysialinsäure für pharmazeutische Applikationen

    Bartling, B., Rehfeld, J. S., Boßmann, D., Scheper, T. & Beutel, S., 28 Aug 2020, In: Chemie Ingenieur Technik. 92, 9, p. 1221 1 p.

    Research output: Contribution to journalArticleResearchpeer review

  43. Published

    Digital image analysis in the lab of the future

    Porr, M. J., Marquard, D., Lange, F. H., Austerjost, J., McVean, K., Hermann, A., Maeß, C., Lindner, P., Scheper, T. & Beutel, S., 28 Aug 2020, In: Chemie Ingenieur Technik. 92, 9, p. 1249 1 p.

    Research output: Contribution to journalMeeting AbstractResearch

  44. Published

    Digitalization in industrial biotechnology: Challenges of miniaturization, automation, and interfaces

    Hemmerich, J., Osthege, M., Reiter, A., Wiechert, W., Noack, S., Oldiges, M., Marquard, D., Porr, M. J., Lange, F. H., Scheper, T., Scheper, T., Beutel, S., von der Eichen, N., Broming, L. & Weuster-Botz, D., 28 Aug 2020, In: Chemie Ingenieur Technik. 92, 9, p. 1160 1 p.

    Research output: Contribution to journalMeeting AbstractResearch

  45. Published

    Aptasensors for point-of-care detection of small molecules

    Prante, M., Segal, E., Scheper, T., Bahnemann, J. & Walter, J., 26 Aug 2020, In: Biosensors. 10, 9, 19 p., 108.

    Research output: Contribution to journalReview articleResearchpeer review

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