Details
| Original language | English |
|---|---|
| Pages (from-to) | 8455-8462 |
| Number of pages | 8 |
| Journal | Advanced functional materials |
| Volume | 26 |
| Issue number | 46 |
| Publication status | Published - 12 Dec 2016 |
| Externally published | Yes |
Abstract
The ability to control the structure and surface chemistry of biomaterials on a molecular level is crucial for optimizing their performance. Here, a novel type of nanoporous organic framework that is suited for the fabrication of thin films is described. These surface-grafted gels (SURGELs) are prepared and functionalized using two orthogonal, metal-free click chemistries. The SURGELs are shown to be cytocompatible and to efficiently mediate adhesion of osteoblast-like cells. This process can be further enhanced by surface modification. In addition, the use of light-triggered reactions in combination with photomasks allows a patterned functionalization of the substrates. The potential to vary and exactly adjust the parameters within the SURGEL polymer network (including porosity and exact network topology on the nanometer scale as well as addressable functional groups) combined with the ability to functionalize their surfaces with any clickable biomolecule of choice in any desired pattern allow the targeted design of novel SURGEL-based biomaterials for applications in nanomedicine, tissue engineering scaffolds, wound dressing,and medical implants.
Keywords
- biofunctionalization, click chemistry, ideal network polymers, metal-organic frameworks, thin films
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Materials Science(all)
- General Materials Science
- Physics and Astronomy(all)
- Condensed Matter Physics
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Advanced functional materials, Vol. 26, No. 46, 12.12.2016, p. 8455-8462.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Tuning the Cell Adhesion on Biofunctionalized Nanoporous Organic Frameworks
AU - Schmitt, Sophia
AU - Huemmer, Julia
AU - Kraus, Saskia
AU - Welle, Alexander
AU - Grosjean, Sylvain
AU - Hanke-Roos, Maximilian
AU - Rosenhahn, Axel
AU - Braese, Stefan
AU - Woell, Christof
AU - Lee-Thedieck, Cornelia
AU - Tsotsalas, Manuel
N1 - Publisher Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/12/12
Y1 - 2016/12/12
N2 - The ability to control the structure and surface chemistry of biomaterials on a molecular level is crucial for optimizing their performance. Here, a novel type of nanoporous organic framework that is suited for the fabrication of thin films is described. These surface-grafted gels (SURGELs) are prepared and functionalized using two orthogonal, metal-free click chemistries. The SURGELs are shown to be cytocompatible and to efficiently mediate adhesion of osteoblast-like cells. This process can be further enhanced by surface modification. In addition, the use of light-triggered reactions in combination with photomasks allows a patterned functionalization of the substrates. The potential to vary and exactly adjust the parameters within the SURGEL polymer network (including porosity and exact network topology on the nanometer scale as well as addressable functional groups) combined with the ability to functionalize their surfaces with any clickable biomolecule of choice in any desired pattern allow the targeted design of novel SURGEL-based biomaterials for applications in nanomedicine, tissue engineering scaffolds, wound dressing,and medical implants.
AB - The ability to control the structure and surface chemistry of biomaterials on a molecular level is crucial for optimizing their performance. Here, a novel type of nanoporous organic framework that is suited for the fabrication of thin films is described. These surface-grafted gels (SURGELs) are prepared and functionalized using two orthogonal, metal-free click chemistries. The SURGELs are shown to be cytocompatible and to efficiently mediate adhesion of osteoblast-like cells. This process can be further enhanced by surface modification. In addition, the use of light-triggered reactions in combination with photomasks allows a patterned functionalization of the substrates. The potential to vary and exactly adjust the parameters within the SURGEL polymer network (including porosity and exact network topology on the nanometer scale as well as addressable functional groups) combined with the ability to functionalize their surfaces with any clickable biomolecule of choice in any desired pattern allow the targeted design of novel SURGEL-based biomaterials for applications in nanomedicine, tissue engineering scaffolds, wound dressing,and medical implants.
KW - biofunctionalization
KW - click chemistry
KW - ideal network polymers
KW - metal-organic frameworks
KW - thin films
UR - http://www.scopus.com/inward/record.url?scp=84990942817&partnerID=8YFLogxK
U2 - 10.1002/adfm.201603054
DO - 10.1002/adfm.201603054
M3 - Article
VL - 26
SP - 8455
EP - 8462
JO - Advanced functional materials
JF - Advanced functional materials
SN - 1616-301X
IS - 46
ER -