Details
| Original language | English |
|---|---|
| Pages (from-to) | 744-757 |
| Number of pages | 14 |
| Journal | Zeitschrift fur Kristallographie |
| Volume | 227 |
| Issue number | 11 |
| Publication status | Published - Nov 2012 |
| Externally published | Yes |
Abstract
Proteins have found their way into many of Nature's structures due to their structural stability, diversity in function and composition, and ability to be regulated as well as be regulators themselves. In this study, we investigate the constitutive amino acids that make up some of these proteins which are involved in CaCO3 mineralization - either in nucleation, crystal growth, or inhibition processes. By assaying all 20 amino acids with vapor diffusion and in situ potentiometric titration, we have found specific amino acids having multiple effects on the early stages of CaCO3 crystallization. These same amino acids have been independently implicated as constituents in liquid- like precursors that form mineralized tissues, processes believed to be key effects of biomineralization proteins in several biological model systems.
Keywords
- Amino acids, Calcium carbonate, Crystal growth, Nucleation, Prenucleation clusters
ASJC Scopus subject areas
- Materials Science(all)
- General Materials Science
- Physics and Astronomy(all)
- Condensed Matter Physics
- Chemistry(all)
- Inorganic Chemistry
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In: Zeitschrift fur Kristallographie, Vol. 227, No. 11, 11.2012, p. 744-757.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The multiple effects of amino acids on the early stages of calcium carbonate crystallization
AU - Picker, Andreas
AU - Kellermeier, Matthias
AU - Seto, Jong
AU - Gebauer, Denis
AU - Cölfen, Helmut
N1 - Funding Information: Acknowledgements. M. K. is grateful to BASF SE for funding a postdoc position.
PY - 2012/11
Y1 - 2012/11
N2 - Proteins have found their way into many of Nature's structures due to their structural stability, diversity in function and composition, and ability to be regulated as well as be regulators themselves. In this study, we investigate the constitutive amino acids that make up some of these proteins which are involved in CaCO3 mineralization - either in nucleation, crystal growth, or inhibition processes. By assaying all 20 amino acids with vapor diffusion and in situ potentiometric titration, we have found specific amino acids having multiple effects on the early stages of CaCO3 crystallization. These same amino acids have been independently implicated as constituents in liquid- like precursors that form mineralized tissues, processes believed to be key effects of biomineralization proteins in several biological model systems.
AB - Proteins have found their way into many of Nature's structures due to their structural stability, diversity in function and composition, and ability to be regulated as well as be regulators themselves. In this study, we investigate the constitutive amino acids that make up some of these proteins which are involved in CaCO3 mineralization - either in nucleation, crystal growth, or inhibition processes. By assaying all 20 amino acids with vapor diffusion and in situ potentiometric titration, we have found specific amino acids having multiple effects on the early stages of CaCO3 crystallization. These same amino acids have been independently implicated as constituents in liquid- like precursors that form mineralized tissues, processes believed to be key effects of biomineralization proteins in several biological model systems.
KW - Amino acids
KW - Calcium carbonate
KW - Crystal growth
KW - Nucleation
KW - Prenucleation clusters
UR - http://www.scopus.com/inward/record.url?scp=84870919697&partnerID=8YFLogxK
U2 - 10.1524/zkri.2012.1569
DO - 10.1524/zkri.2012.1569
M3 - Article
AN - SCOPUS:84870919697
VL - 227
SP - 744
EP - 757
JO - Zeitschrift fur Kristallographie
JF - Zeitschrift fur Kristallographie
SN - 0044-2968
IS - 11
ER -