Details
| Original language | English |
|---|---|
| Pages (from-to) | 295-313 |
| Number of pages | 19 |
| Journal | MITOCHONDRION |
| Volume | 19 |
| Issue number | PB |
| Publication status | Published - 21 Feb 2014 |
Abstract
The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.
Keywords
- Carbonic anhydrase, Oxidative phosphorylation, Oxidoreductase, Plant mitochondria, Reactive oxygen species, RNA editing
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
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In: MITOCHONDRION, Vol. 19, No. PB, 21.02.2014, p. 295-313.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The life of plant mitochondrial complex I
AU - Braun, Hans Peter
AU - Binder, Stefan
AU - Brennicke, Axel
AU - Eubel, Holger
AU - Fernie, Alisdair R.
AU - Finkemeier, Iris
AU - Klodmann, Jennifer
AU - König, Ann Christine
AU - Kühn, Kristina
AU - Meyer, Etienne
AU - Obata, Toshihiro
AU - Schwarzländer, Markus
AU - Takenaka, Mizuki
AU - Zehrmann, Anja
N1 - Funding information: This article summarizes contributions related to plant mitochondrial complex I presented at the 8th International Conference on Plant Mitochondrial Biology (ICPMB) which was held from May 12 to 16, 2013 in Rosario, Argentina. The authors wish to thank the organizing committee for arranging a wonderful conference. Furthermore, the authors thank the Center for Advanced Studies (CAS) of the Ludwig-Maximilians-University Munich for supporting the Symposium “The life of plant mitochondrial complex I” held in Munich on November 4/5, 2013. We thank Christine Schikowsky, Leibniz University Hannover/Germany, for the artwork of the article. Our research is supported by the Deutsche Forschungsgemeinschaft (grants BR1829-10/2 [HPB], BR326-11/1 [AB], FE552-9/2 [ARF], IF1655-1/1 [IF], SCHW 1719-1/1 [MS], TA624-2/2 [MT] and TA624-4/1 [MT]).
PY - 2014/2/21
Y1 - 2014/2/21
N2 - The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.
AB - The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.
KW - Carbonic anhydrase
KW - Oxidative phosphorylation
KW - Oxidoreductase
KW - Plant mitochondria
KW - Reactive oxygen species
KW - RNA editing
UR - http://www.scopus.com/inward/record.url?scp=84914170647&partnerID=8YFLogxK
U2 - 10.15488/11656
DO - 10.15488/11656
M3 - Article
C2 - 24561573
AN - SCOPUS:84914170647
VL - 19
SP - 295
EP - 313
JO - MITOCHONDRION
JF - MITOCHONDRION
SN - 1567-7249
IS - PB
ER -