Details
| Original language | English |
|---|---|
| Pages (from-to) | 7580-7589 |
| Number of pages | 10 |
| Journal | Acta biomaterialia |
| Volume | 9 |
| Issue number | 7 |
| Early online date | 19 Mar 2013 |
| Publication status | Published - Jul 2013 |
Abstract
Magnesium alloys have been proposed as prospective degradable implant materials. To elucidate the complex interactions between the corroding implants and the tissue, magnesium implants were analyzed in a mouse model and the response was compared to that induced by Ti and by the resorbable polymer polyglactin, respectively. One month after implantation, distinct traces of corrosion were apparent but the magnesium implants were still intact, whereas resorbable polymeric wound suture implants were already fragmented. Analysis of magnesium implants 2 weeks after implantation by energy-dispersive X-ray spectroscopy indicated that magnesium, oxygen, calcium and phosphate were present at the implant surface. One month after implantation, the element composition of the outermost layer of the implant was indicative of tissue without detectable levels of magnesium, indicating a protective barrier function of this organic layer. In agreement with this notion, gene expression patterns in the surrounding tissue were highly similar for all implant materials investigated. However, high-resolution imaging using energy-filtered transmission electron microscopy revealed magnesium-containing microparticles in the tissue in the proximity of the implant. The release of such corrosion particles may contribute to the accumulation of calcium phosphate in the nearby tissue and to bone conductive activities of magnesium implants.
Keywords
- Animal model, Biocompatibility, Biodegradation, In vivo test, Magnesium
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Materials Science(all)
- Biomaterials
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Engineering(all)
- Biomedical Engineering
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
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In: Acta biomaterialia, Vol. 9, No. 7, 07.2013, p. 7580-7589.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - The formation of an organic coat and the release of corrosion microparticles from metallic magnesium implants
AU - Badar, Muhammad
AU - Lünsdorf, Heinrich
AU - Evertz, Florian
AU - Rahim, Muhammad Imran
AU - Glasmacher, Birgit
AU - Hauser, Hansjörg
AU - Mueller, Peter P.
N1 - Funding Information: The skillful work of Inge Kristen (VAM, HZI) involving sample preparation for electron microscopy is gratefully acknowledged. This research was funded by the German Research Foundation (DFG) grant SFB 599 “Sustainable Bioresorbable and Permanent Implants of Metallic and Ceramic Materials”. M.B. and M.I.R. were supported by a joint grant of the DAAD, Germany and the Higher Education Commission of Pakistan.
PY - 2013/7
Y1 - 2013/7
N2 - Magnesium alloys have been proposed as prospective degradable implant materials. To elucidate the complex interactions between the corroding implants and the tissue, magnesium implants were analyzed in a mouse model and the response was compared to that induced by Ti and by the resorbable polymer polyglactin, respectively. One month after implantation, distinct traces of corrosion were apparent but the magnesium implants were still intact, whereas resorbable polymeric wound suture implants were already fragmented. Analysis of magnesium implants 2 weeks after implantation by energy-dispersive X-ray spectroscopy indicated that magnesium, oxygen, calcium and phosphate were present at the implant surface. One month after implantation, the element composition of the outermost layer of the implant was indicative of tissue without detectable levels of magnesium, indicating a protective barrier function of this organic layer. In agreement with this notion, gene expression patterns in the surrounding tissue were highly similar for all implant materials investigated. However, high-resolution imaging using energy-filtered transmission electron microscopy revealed magnesium-containing microparticles in the tissue in the proximity of the implant. The release of such corrosion particles may contribute to the accumulation of calcium phosphate in the nearby tissue and to bone conductive activities of magnesium implants.
AB - Magnesium alloys have been proposed as prospective degradable implant materials. To elucidate the complex interactions between the corroding implants and the tissue, magnesium implants were analyzed in a mouse model and the response was compared to that induced by Ti and by the resorbable polymer polyglactin, respectively. One month after implantation, distinct traces of corrosion were apparent but the magnesium implants were still intact, whereas resorbable polymeric wound suture implants were already fragmented. Analysis of magnesium implants 2 weeks after implantation by energy-dispersive X-ray spectroscopy indicated that magnesium, oxygen, calcium and phosphate were present at the implant surface. One month after implantation, the element composition of the outermost layer of the implant was indicative of tissue without detectable levels of magnesium, indicating a protective barrier function of this organic layer. In agreement with this notion, gene expression patterns in the surrounding tissue were highly similar for all implant materials investigated. However, high-resolution imaging using energy-filtered transmission electron microscopy revealed magnesium-containing microparticles in the tissue in the proximity of the implant. The release of such corrosion particles may contribute to the accumulation of calcium phosphate in the nearby tissue and to bone conductive activities of magnesium implants.
KW - Animal model
KW - Biocompatibility
KW - Biodegradation
KW - In vivo test
KW - Magnesium
UR - http://www.scopus.com/inward/record.url?scp=84878273599&partnerID=8YFLogxK
U2 - 10.1016/j.actbio.2013.03.012
DO - 10.1016/j.actbio.2013.03.012
M3 - Article
C2 - 23518475
AN - SCOPUS:84878273599
VL - 9
SP - 7580
EP - 7589
JO - Acta biomaterialia
JF - Acta biomaterialia
SN - 1742-7061
IS - 7
ER -