Details
| Original language | English |
|---|---|
| Pages (from-to) | 871-876 |
| Number of pages | 6 |
| Journal | Current genetics |
| Volume | 65 |
| Issue number | 4 |
| Early online date | 4 Mar 2019 |
| Publication status | Published - 1 Aug 2019 |
Abstract
Spx is a central regulator of the Bacillus subtilis stress response. By binding to the alpha subunits of RNA polymerase, it regulates the expression of many stress response genes, while concurrently interfering with various developmental processes. The recent observation that Spx also represses transcription of ribosomal RNA adds a direct link between stress response and the control of translation in B. subtilis. Here, we discuss the significance of the regulation of translation and the transcription of translation-related genes during the bacterial stress response and the role of Spx in this process. Furthermore, we compare Spx with the role of DksA during stress response in proteobacteria.
Keywords
- Bacillus subtilis, DksA, Heat shock response, Spx, Stringent response, Transcriptional regulation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics
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In: Current genetics, Vol. 65, No. 4, 01.08.2019, p. 871-876.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Spx, a versatile regulator of the Bacillus subtilis stress response
AU - Schäfer, Heinrich
AU - Turgay, Kürşad
N1 - Publisher Copyright: © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Spx is a central regulator of the Bacillus subtilis stress response. By binding to the alpha subunits of RNA polymerase, it regulates the expression of many stress response genes, while concurrently interfering with various developmental processes. The recent observation that Spx also represses transcription of ribosomal RNA adds a direct link between stress response and the control of translation in B. subtilis. Here, we discuss the significance of the regulation of translation and the transcription of translation-related genes during the bacterial stress response and the role of Spx in this process. Furthermore, we compare Spx with the role of DksA during stress response in proteobacteria.
AB - Spx is a central regulator of the Bacillus subtilis stress response. By binding to the alpha subunits of RNA polymerase, it regulates the expression of many stress response genes, while concurrently interfering with various developmental processes. The recent observation that Spx also represses transcription of ribosomal RNA adds a direct link between stress response and the control of translation in B. subtilis. Here, we discuss the significance of the regulation of translation and the transcription of translation-related genes during the bacterial stress response and the role of Spx in this process. Furthermore, we compare Spx with the role of DksA during stress response in proteobacteria.
KW - Bacillus subtilis
KW - DksA
KW - Heat shock response
KW - Spx
KW - Stringent response
KW - Transcriptional regulation
UR - http://www.scopus.com/inward/record.url?scp=85062692821&partnerID=8YFLogxK
U2 - 10.1007/s00294-019-00950-6
DO - 10.1007/s00294-019-00950-6
M3 - Article
C2 - 30830258
AN - SCOPUS:85062692821
VL - 65
SP - 871
EP - 876
JO - Current genetics
JF - Current genetics
SN - 0172-8083
IS - 4
ER -