Details
| Original language | English |
|---|---|
| Pages (from-to) | 29768-29772 |
| Number of pages | 5 |
| Journal | RSC Advances |
| Volume | 13 |
| Issue number | 42 |
| Publication status | Published - 11 Oct 2023 |
Abstract
Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Chemical Engineering(all)
- General Chemical Engineering
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In: RSC Advances, Vol. 13, No. 42, 11.10.2023, p. 29768-29772.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Sporothioethers
T2 - deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
AU - Heinemann, Henrike
AU - Becker, Kevin
AU - Schrey, Hedda
AU - Zeng, Haoxuan
AU - Stadler, Marc
AU - Cox, Russell J.
N1 - Funding Information: This work was funded by the Deutsche Forschungsgemeinschaft priority program “Taxon-Omics: New Approaches for Discovering and Naming Biodiversity” (SPP 1991), specifically CO 1328/4-2 and CO 1328/4-1 and by personal PhD stipend from the “Drug Discovery and Cheminformatics for New Anti-Infectives (iCA)” to HZ, and is financially supported by the Ministry for Science & Culture of the German State of Lower Saxony (MWK no. 21—78904-63-5/19). HH gratefully acknowledges funding from the Leibniz University Hannover. The publication of this article was partially funded by the Open Access Fund of the Leibniz University of Hannover.
PY - 2023/10/11
Y1 - 2023/10/11
N2 - Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.
AB - Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.
UR - http://www.scopus.com/inward/record.url?scp=85177495994&partnerID=8YFLogxK
U2 - 10.1039/d3ra06542a
DO - 10.1039/d3ra06542a
M3 - Article
AN - SCOPUS:85177495994
VL - 13
SP - 29768
EP - 29772
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 42
ER -