Details
| Original language | English |
|---|---|
| Pages (from-to) | 18-23 |
| Number of pages | 6 |
| Journal | Natural Product Reports |
| Volume | 38 |
| Issue number | 1 |
| Early online date | 23 Jul 2020 |
| Publication status | Published - 2021 |
Abstract
Covering: up to the beginning of 2020Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Organic Chemistry
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In: Natural Product Reports, Vol. 38, No. 1, 2021, p. 18-23.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Rocaglamide and silvestrol
T2 - a long story from anti-tumor to anti-coronavirus compounds
AU - Schulz, Göran
AU - Victoria, Catherine
AU - Kirschning, Andreas
AU - Steinmann, Eike
PY - 2021
Y1 - 2021
N2 - Covering: up to the beginning of 2020Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.
AB - Covering: up to the beginning of 2020Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85101029616&partnerID=8YFLogxK
U2 - 10.1039/d0np00024h
DO - 10.1039/d0np00024h
M3 - Article
C2 - 32699874
VL - 38
SP - 18
EP - 23
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 1
ER -