Reliable Detection of Chemical Warfare Agents Using High Kinetic Energy Ion Mobility Spectrometry

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Christoph Schaefer
  • Maria Allers
  • Moritz Hitzemann
  • Alexander Nitschke
  • Tim Kobelt
  • Max Mörtel
  • Stefanie Schröder
  • Arne Ficks
  • Stefan Zimmermann

External Research Organisations

  • Wehrwissenschaftliches Institut für Schutztechnologien ABC -Schutz (WIS)
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Details

Original languageEnglish
Pages (from-to)2008-2019
Number of pages12
JournalJournal of the American Society for Mass Spectrometry
Volume35
Issue number8
Early online date16 Jul 2024
Publication statusPublished - 7 Aug 2024

Abstract

High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) ionize and separate ions at reduced pressures of 10-40 mbar and over a wide range of reduced electric field strengths E/N of up to 120 Td. Their reduced operating pressure is distinct from that of conventional drift tube ion mobility spectrometers that operate at ambient pressure for trace compound detection. High E/N can lead to a field-induced fragmentation pattern that provides more specific structural information about the analytes. In addition, operation at high E/N values adds the field dependence of ion mobility as an additional separation dimension to low-field ion mobility, making interfering compounds less likely to cause a false positive alarm. In this work, we study the chemical warfare agents tabun (GA), sarin (GB), soman (GD), cyclosarin (GF) and sulfur mustard (HD) in a HiKE-IMS at variable E/N in both the reaction and the drift region. The results show that varying E/N can lead to specific fragmentation patterns at high E/N values combined with molecular signals at low E/N. Compared to the operation at a single E/N value in the drift region, the variation of E/N in the drift region also provides the analyte-specific field dependence of ion mobility as additional information. The accumulated data establish a unique fingerprint for each analyte that allows for reliable detection of chemical warfare agents even in the presence of interfering compounds with similar low-field ion mobilities, thus reducing false positives.

ASJC Scopus subject areas

Cite this

Reliable Detection of Chemical Warfare Agents Using High Kinetic Energy Ion Mobility Spectrometry. / Schaefer, Christoph; Allers, Maria; Hitzemann, Moritz et al.
In: Journal of the American Society for Mass Spectrometry, Vol. 35, No. 8, 07.08.2024, p. 2008-2019.

Research output: Contribution to journalArticleResearchpeer review

Schaefer, C, Allers, M, Hitzemann, M, Nitschke, A, Kobelt, T, Mörtel, M, Schröder, S, Ficks, A & Zimmermann, S 2024, 'Reliable Detection of Chemical Warfare Agents Using High Kinetic Energy Ion Mobility Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 35, no. 8, pp. 2008-2019. https://doi.org/10.1021/jasms.4c00240
Schaefer C, Allers M, Hitzemann M, Nitschke A, Kobelt T, Mörtel M et al. Reliable Detection of Chemical Warfare Agents Using High Kinetic Energy Ion Mobility Spectrometry. Journal of the American Society for Mass Spectrometry. 2024 Aug 7;35(8):2008-2019. Epub 2024 Jul 16. doi: 10.1021/jasms.4c00240
Schaefer, Christoph ; Allers, Maria ; Hitzemann, Moritz et al. / Reliable Detection of Chemical Warfare Agents Using High Kinetic Energy Ion Mobility Spectrometry. In: Journal of the American Society for Mass Spectrometry. 2024 ; Vol. 35, No. 8. pp. 2008-2019.
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AU - Schröder, Stefanie

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