Details
Original language | English |
---|---|
Article number | 896719 |
Journal | Frontiers in Bioengineering and Biotechnology |
Volume | 10 |
Publication status | Published - 17 Aug 2022 |
Abstract
Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.
Keywords
- 3D printing, electrospinning, melt electro writing, scaffolds, tissue engineering
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Medicine(all)
- Histology
- Engineering(all)
- Biomedical Engineering
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In: Frontiers in Bioengineering and Biotechnology, Vol. 10, 896719, 17.08.2022.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering
AU - Loewner, Sebastian
AU - Heene, Sebastian
AU - Baroth, Timo
AU - Heymann, Henrik
AU - Cholewa, Fabian
AU - Blume, Holger
AU - Blume, Cornelia
N1 - Funding Information: This work has been carried out within the framework of the SMART BIOTECS alliance between the Technische Universitaet Braunschweig and the Leibniz Universitaet Hannover. This initiative is supported by the Ministry of Economy and Culture (MWK) of Lower Saxony, Germany. The publication of this article was funded by the Open Access Fund of Leibniz Universitaet Hannover.
PY - 2022/8/17
Y1 - 2022/8/17
N2 - Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.
AB - Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.
KW - 3D printing
KW - electrospinning
KW - melt electro writing
KW - scaffolds
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85137148318&partnerID=8YFLogxK
U2 - 10.3389/fbioe.2022.896719
DO - 10.3389/fbioe.2022.896719
M3 - Review article
C2 - 36061443
VL - 10
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
SN - 2296-4185
M1 - 896719
ER -