Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering

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Original languageEnglish
Article number896719
JournalFrontiers in Bioengineering and Biotechnology
Volume10
Publication statusPublished - 17 Aug 2022

Abstract

Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.

Keywords

    3D printing, electrospinning, melt electro writing, scaffolds, tissue engineering

ASJC Scopus subject areas

Cite this

Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering. / Loewner, Sebastian; Heene, Sebastian; Baroth, Timo et al.
In: Frontiers in Bioengineering and Biotechnology, Vol. 10, 896719, 17.08.2022.

Research output: Contribution to journalReview articleResearchpeer review

Loewner S, Heene S, Baroth T, Heymann H, Cholewa F, Blume H et al. Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering. Frontiers in Bioengineering and Biotechnology. 2022 Aug 17;10:896719. doi: 10.3389/fbioe.2022.896719
Loewner, Sebastian ; Heene, Sebastian ; Baroth, Timo et al. / Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering. In: Frontiers in Bioengineering and Biotechnology. 2022 ; Vol. 10.
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title = "Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering",
abstract = "Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.",
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author = "Sebastian Loewner and Sebastian Heene and Timo Baroth and Henrik Heymann and Fabian Cholewa and Holger Blume and Cornelia Blume",
note = "Funding Information: This work has been carried out within the framework of the SMART BIOTECS alliance between the Technische Universitaet Braunschweig and the Leibniz Universitaet Hannover. This initiative is supported by the Ministry of Economy and Culture (MWK) of Lower Saxony, Germany. The publication of this article was funded by the Open Access Fund of Leibniz Universitaet Hannover.",
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AU - Loewner, Sebastian

AU - Heene, Sebastian

AU - Baroth, Timo

AU - Heymann, Henrik

AU - Cholewa, Fabian

AU - Blume, Holger

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PY - 2022/8/17

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N2 - Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.

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KW - tissue engineering

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