Details
Original language | English |
---|---|
Article number | uqad015 |
Journal | MicroLife |
Volume | 4 |
Publication status | Published - 17 Apr 2023 |
Abstract
Nucleotide second messengers act as intracellular 'secondary' signals that represent environmental or cellular cues, i.e. the 'primary' signals. As such, they are linking sensory input with regulatory output in all living cells. The amazing physiological versatility, the mechanistic diversity of second messenger synthesis, degradation, and action as well as the high level of integration of second messenger pathways and networks in prokaryotes has only recently become apparent. In these networks, specific secondmessengers play conserved general roles. Thus, (p)ppGpp coordinates growth and survival in response to nutrient availability and various stresses, while c-di-GMP is the nucleotide signalingmolecule to orchestrate bacterial adhesion andmulticellularity. c-di-AMP links osmotic balance andmetabolism and that it does so even in Archaeamay suggest a very early evolutionary origin of secondmessenger signaling. Many of the enzymes that make or break second messengers show complex sensory domain architectures, which allow multisignal integration. The multiplicity of c-di-GMP-related enzymes in many species has led to the discovery that bacterial cells are even able to use the same freely diffusible second messenger in local signaling pathways that can act in parallel without cross-talking. On the other hand, signaling pathways operating with different nucleotides can intersect in elaborate signaling networks. Apart from the small number of common signaling nucleotides that bacteria use for controlling their cellular "business,"diverse nucleotides were recently found to play very specific roles in phage defense. Furthermore, these systems represent the phylogenetic ancestors of cyclic nucleotide-activated immune signaling in eukaryotes.
Keywords
- ApA, biofilm, c-di-AMP, c-di-GMP, CBASS, cGAMP, ppGpp
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- General Immunology and Microbiology
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In: MicroLife, Vol. 4, uqad015, 17.04.2023.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Recent advances and perspectives in nucleotide second messenger signaling in bacteria
AU - Hengge, Regine
AU - Pruteanu, Mihaela
AU - Stülke, Jörg
AU - Tschowri, Natalia
AU - Turgay, Kürşad
PY - 2023/4/17
Y1 - 2023/4/17
N2 - Nucleotide second messengers act as intracellular 'secondary' signals that represent environmental or cellular cues, i.e. the 'primary' signals. As such, they are linking sensory input with regulatory output in all living cells. The amazing physiological versatility, the mechanistic diversity of second messenger synthesis, degradation, and action as well as the high level of integration of second messenger pathways and networks in prokaryotes has only recently become apparent. In these networks, specific secondmessengers play conserved general roles. Thus, (p)ppGpp coordinates growth and survival in response to nutrient availability and various stresses, while c-di-GMP is the nucleotide signalingmolecule to orchestrate bacterial adhesion andmulticellularity. c-di-AMP links osmotic balance andmetabolism and that it does so even in Archaeamay suggest a very early evolutionary origin of secondmessenger signaling. Many of the enzymes that make or break second messengers show complex sensory domain architectures, which allow multisignal integration. The multiplicity of c-di-GMP-related enzymes in many species has led to the discovery that bacterial cells are even able to use the same freely diffusible second messenger in local signaling pathways that can act in parallel without cross-talking. On the other hand, signaling pathways operating with different nucleotides can intersect in elaborate signaling networks. Apart from the small number of common signaling nucleotides that bacteria use for controlling their cellular "business,"diverse nucleotides were recently found to play very specific roles in phage defense. Furthermore, these systems represent the phylogenetic ancestors of cyclic nucleotide-activated immune signaling in eukaryotes.
AB - Nucleotide second messengers act as intracellular 'secondary' signals that represent environmental or cellular cues, i.e. the 'primary' signals. As such, they are linking sensory input with regulatory output in all living cells. The amazing physiological versatility, the mechanistic diversity of second messenger synthesis, degradation, and action as well as the high level of integration of second messenger pathways and networks in prokaryotes has only recently become apparent. In these networks, specific secondmessengers play conserved general roles. Thus, (p)ppGpp coordinates growth and survival in response to nutrient availability and various stresses, while c-di-GMP is the nucleotide signalingmolecule to orchestrate bacterial adhesion andmulticellularity. c-di-AMP links osmotic balance andmetabolism and that it does so even in Archaeamay suggest a very early evolutionary origin of secondmessenger signaling. Many of the enzymes that make or break second messengers show complex sensory domain architectures, which allow multisignal integration. The multiplicity of c-di-GMP-related enzymes in many species has led to the discovery that bacterial cells are even able to use the same freely diffusible second messenger in local signaling pathways that can act in parallel without cross-talking. On the other hand, signaling pathways operating with different nucleotides can intersect in elaborate signaling networks. Apart from the small number of common signaling nucleotides that bacteria use for controlling their cellular "business,"diverse nucleotides were recently found to play very specific roles in phage defense. Furthermore, these systems represent the phylogenetic ancestors of cyclic nucleotide-activated immune signaling in eukaryotes.
KW - ApA
KW - biofilm
KW - c-di-AMP
KW - c-di-GMP
KW - CBASS
KW - cGAMP
KW - ppGpp
UR - http://www.scopus.com/inward/record.url?scp=85174328766&partnerID=8YFLogxK
U2 - 10.1093/femsml/uqad015
DO - 10.1093/femsml/uqad015
M3 - Review article
AN - SCOPUS:85174328766
VL - 4
JO - MicroLife
JF - MicroLife
M1 - uqad015
ER -