Recent advances and perspectives in nucleotide second messenger signaling in bacteria

Research output: Contribution to journalReview articleResearchpeer review

Authors

Research Organisations

External Research Organisations

  • Humboldt-Universität zu Berlin (HU Berlin)
  • University of Göttingen
  • Max Planck Unit for the Science of Pathogens (MPUSP)
View graph of relations

Details

Original languageEnglish
Article numberuqad015
JournalMicroLife
Volume4
Publication statusPublished - 17 Apr 2023

Abstract

Nucleotide second messengers act as intracellular 'secondary' signals that represent environmental or cellular cues, i.e. the 'primary' signals. As such, they are linking sensory input with regulatory output in all living cells. The amazing physiological versatility, the mechanistic diversity of second messenger synthesis, degradation, and action as well as the high level of integration of second messenger pathways and networks in prokaryotes has only recently become apparent. In these networks, specific secondmessengers play conserved general roles. Thus, (p)ppGpp coordinates growth and survival in response to nutrient availability and various stresses, while c-di-GMP is the nucleotide signalingmolecule to orchestrate bacterial adhesion andmulticellularity. c-di-AMP links osmotic balance andmetabolism and that it does so even in Archaeamay suggest a very early evolutionary origin of secondmessenger signaling. Many of the enzymes that make or break second messengers show complex sensory domain architectures, which allow multisignal integration. The multiplicity of c-di-GMP-related enzymes in many species has led to the discovery that bacterial cells are even able to use the same freely diffusible second messenger in local signaling pathways that can act in parallel without cross-talking. On the other hand, signaling pathways operating with different nucleotides can intersect in elaborate signaling networks. Apart from the small number of common signaling nucleotides that bacteria use for controlling their cellular "business,"diverse nucleotides were recently found to play very specific roles in phage defense. Furthermore, these systems represent the phylogenetic ancestors of cyclic nucleotide-activated immune signaling in eukaryotes.

Keywords

    ApA, biofilm, c-di-AMP, c-di-GMP, CBASS, cGAMP, ppGpp

ASJC Scopus subject areas

Cite this

Recent advances and perspectives in nucleotide second messenger signaling in bacteria. / Hengge, Regine; Pruteanu, Mihaela; Stülke, Jörg et al.
In: MicroLife, Vol. 4, uqad015, 17.04.2023.

Research output: Contribution to journalReview articleResearchpeer review

Hengge, R., Pruteanu, M., Stülke, J., Tschowri, N., & Turgay, K. (2023). Recent advances and perspectives in nucleotide second messenger signaling in bacteria. MicroLife, 4, Article uqad015. https://doi.org/10.1093/femsml/uqad015
Hengge R, Pruteanu M, Stülke J, Tschowri N, Turgay K. Recent advances and perspectives in nucleotide second messenger signaling in bacteria. MicroLife. 2023 Apr 17;4:uqad015. doi: 10.1093/femsml/uqad015
Hengge, Regine ; Pruteanu, Mihaela ; Stülke, Jörg et al. / Recent advances and perspectives in nucleotide second messenger signaling in bacteria. In: MicroLife. 2023 ; Vol. 4.
Download
@article{d7db368e236c4180b8fe5bdebc49bd3d,
title = "Recent advances and perspectives in nucleotide second messenger signaling in bacteria",
abstract = "Nucleotide second messengers act as intracellular 'secondary' signals that represent environmental or cellular cues, i.e. the 'primary' signals. As such, they are linking sensory input with regulatory output in all living cells. The amazing physiological versatility, the mechanistic diversity of second messenger synthesis, degradation, and action as well as the high level of integration of second messenger pathways and networks in prokaryotes has only recently become apparent. In these networks, specific secondmessengers play conserved general roles. Thus, (p)ppGpp coordinates growth and survival in response to nutrient availability and various stresses, while c-di-GMP is the nucleotide signalingmolecule to orchestrate bacterial adhesion andmulticellularity. c-di-AMP links osmotic balance andmetabolism and that it does so even in Archaeamay suggest a very early evolutionary origin of secondmessenger signaling. Many of the enzymes that make or break second messengers show complex sensory domain architectures, which allow multisignal integration. The multiplicity of c-di-GMP-related enzymes in many species has led to the discovery that bacterial cells are even able to use the same freely diffusible second messenger in local signaling pathways that can act in parallel without cross-talking. On the other hand, signaling pathways operating with different nucleotides can intersect in elaborate signaling networks. Apart from the small number of common signaling nucleotides that bacteria use for controlling their cellular {"}business,{"}diverse nucleotides were recently found to play very specific roles in phage defense. Furthermore, these systems represent the phylogenetic ancestors of cyclic nucleotide-activated immune signaling in eukaryotes.",
keywords = "ApA, biofilm, c-di-AMP, c-di-GMP, CBASS, cGAMP, ppGpp",
author = "Regine Hengge and Mihaela Pruteanu and J{\"o}rg St{\"u}lke and Natalia Tschowri and K{\"u}r{\c s}ad Turgay",
year = "2023",
month = apr,
day = "17",
doi = "10.1093/femsml/uqad015",
language = "English",
volume = "4",

}

Download

TY - JOUR

T1 - Recent advances and perspectives in nucleotide second messenger signaling in bacteria

AU - Hengge, Regine

AU - Pruteanu, Mihaela

AU - Stülke, Jörg

AU - Tschowri, Natalia

AU - Turgay, Kürşad

PY - 2023/4/17

Y1 - 2023/4/17

N2 - Nucleotide second messengers act as intracellular 'secondary' signals that represent environmental or cellular cues, i.e. the 'primary' signals. As such, they are linking sensory input with regulatory output in all living cells. The amazing physiological versatility, the mechanistic diversity of second messenger synthesis, degradation, and action as well as the high level of integration of second messenger pathways and networks in prokaryotes has only recently become apparent. In these networks, specific secondmessengers play conserved general roles. Thus, (p)ppGpp coordinates growth and survival in response to nutrient availability and various stresses, while c-di-GMP is the nucleotide signalingmolecule to orchestrate bacterial adhesion andmulticellularity. c-di-AMP links osmotic balance andmetabolism and that it does so even in Archaeamay suggest a very early evolutionary origin of secondmessenger signaling. Many of the enzymes that make or break second messengers show complex sensory domain architectures, which allow multisignal integration. The multiplicity of c-di-GMP-related enzymes in many species has led to the discovery that bacterial cells are even able to use the same freely diffusible second messenger in local signaling pathways that can act in parallel without cross-talking. On the other hand, signaling pathways operating with different nucleotides can intersect in elaborate signaling networks. Apart from the small number of common signaling nucleotides that bacteria use for controlling their cellular "business,"diverse nucleotides were recently found to play very specific roles in phage defense. Furthermore, these systems represent the phylogenetic ancestors of cyclic nucleotide-activated immune signaling in eukaryotes.

AB - Nucleotide second messengers act as intracellular 'secondary' signals that represent environmental or cellular cues, i.e. the 'primary' signals. As such, they are linking sensory input with regulatory output in all living cells. The amazing physiological versatility, the mechanistic diversity of second messenger synthesis, degradation, and action as well as the high level of integration of second messenger pathways and networks in prokaryotes has only recently become apparent. In these networks, specific secondmessengers play conserved general roles. Thus, (p)ppGpp coordinates growth and survival in response to nutrient availability and various stresses, while c-di-GMP is the nucleotide signalingmolecule to orchestrate bacterial adhesion andmulticellularity. c-di-AMP links osmotic balance andmetabolism and that it does so even in Archaeamay suggest a very early evolutionary origin of secondmessenger signaling. Many of the enzymes that make or break second messengers show complex sensory domain architectures, which allow multisignal integration. The multiplicity of c-di-GMP-related enzymes in many species has led to the discovery that bacterial cells are even able to use the same freely diffusible second messenger in local signaling pathways that can act in parallel without cross-talking. On the other hand, signaling pathways operating with different nucleotides can intersect in elaborate signaling networks. Apart from the small number of common signaling nucleotides that bacteria use for controlling their cellular "business,"diverse nucleotides were recently found to play very specific roles in phage defense. Furthermore, these systems represent the phylogenetic ancestors of cyclic nucleotide-activated immune signaling in eukaryotes.

KW - ApA

KW - biofilm

KW - c-di-AMP

KW - c-di-GMP

KW - CBASS

KW - cGAMP

KW - ppGpp

UR - http://www.scopus.com/inward/record.url?scp=85174328766&partnerID=8YFLogxK

U2 - 10.1093/femsml/uqad015

DO - 10.1093/femsml/uqad015

M3 - Review article

AN - SCOPUS:85174328766

VL - 4

JO - MicroLife

JF - MicroLife

M1 - uqad015

ER -

By the same author(s)