Details
| Original language | English |
|---|---|
| Pages (from-to) | 908-927 |
| Number of pages | 20 |
| Journal | Journal of molecular biology |
| Volume | 431 |
| Issue number | 5 |
| Early online date | 19 Jan 2019 |
| Publication status | Published - 1 Mar 2019 |
Abstract
The “International Symposium on Nucleotide Second Messenger Signaling in Bacteria” (September 30–October 3, 2018, Berlin), which was organized within the framework of DFG Priority Programme 1879 (www.spp1879.de), brought together 125 participants from 20 countries to discuss recent progress and future trends in this field. Even 50 years after its discovery, (p)ppGpp is venturing into exciting new fields, especially in gram-positive bacteria. After triggering the current renaissance in bacterial second messenger research, c-di-GMP is becoming ever more global with abounding new molecular mechanisms of action and physiological functions. The more recently discovered c-di-AMP is rapidly catching up and has now been found even in archaea, with its function in osmotic homeostasis being conserved across kingdom boundaries. Small modules associated with mobile genetic elements, which make and react to numerous novel mixed cyclic dinucleotides, seem to roam around rather freely in the bacterial world. Finally, many novel and old nucleotide molecules are still lurking around in search of a function. Across many talks it became apparent that (p)ppGpp, c-di-GMP and GTP/ATP can share and compete for binding sites (e.g., the Walker A motif in GTP/ATPases) with intriguing regulatory consequences, thus contributing to the emergent trend of systemwide networks that interconnect diverse signaling nucleotides. Overall, this inspiring conference made it clear that second messenger signaling is currently one of the most dynamic and exciting areas in microbial molecular biology and physiology, with major impacts ranging from microbial systems biology and ecology to infection biology.
Keywords
- biofilm, c-di-AMP, c-di-GMP, cGAMP, ppGpp
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Structural Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
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In: Journal of molecular biology, Vol. 431, No. 5, 01.03.2019, p. 908-927.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Recent Advances and Current Trends in Nucleotide Second Messenger Signaling in Bacteria
AU - Hengge, Regine
AU - Häussler, Susanne
AU - Pruteanu, Mihaela
AU - Stülke, Jörg
AU - Tschowri, Natalia
AU - Turgay, Kürşad
N1 - Funding Information: Financial support for the symposium was provided by a Deutsche Forschungsgemeinschaft Priority Programme (DFG SPP 1879). In addition, also the relevant research projects of the authors (except M.P.) are being funded by the same DFG program.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The “International Symposium on Nucleotide Second Messenger Signaling in Bacteria” (September 30–October 3, 2018, Berlin), which was organized within the framework of DFG Priority Programme 1879 (www.spp1879.de), brought together 125 participants from 20 countries to discuss recent progress and future trends in this field. Even 50 years after its discovery, (p)ppGpp is venturing into exciting new fields, especially in gram-positive bacteria. After triggering the current renaissance in bacterial second messenger research, c-di-GMP is becoming ever more global with abounding new molecular mechanisms of action and physiological functions. The more recently discovered c-di-AMP is rapidly catching up and has now been found even in archaea, with its function in osmotic homeostasis being conserved across kingdom boundaries. Small modules associated with mobile genetic elements, which make and react to numerous novel mixed cyclic dinucleotides, seem to roam around rather freely in the bacterial world. Finally, many novel and old nucleotide molecules are still lurking around in search of a function. Across many talks it became apparent that (p)ppGpp, c-di-GMP and GTP/ATP can share and compete for binding sites (e.g., the Walker A motif in GTP/ATPases) with intriguing regulatory consequences, thus contributing to the emergent trend of systemwide networks that interconnect diverse signaling nucleotides. Overall, this inspiring conference made it clear that second messenger signaling is currently one of the most dynamic and exciting areas in microbial molecular biology and physiology, with major impacts ranging from microbial systems biology and ecology to infection biology.
AB - The “International Symposium on Nucleotide Second Messenger Signaling in Bacteria” (September 30–October 3, 2018, Berlin), which was organized within the framework of DFG Priority Programme 1879 (www.spp1879.de), brought together 125 participants from 20 countries to discuss recent progress and future trends in this field. Even 50 years after its discovery, (p)ppGpp is venturing into exciting new fields, especially in gram-positive bacteria. After triggering the current renaissance in bacterial second messenger research, c-di-GMP is becoming ever more global with abounding new molecular mechanisms of action and physiological functions. The more recently discovered c-di-AMP is rapidly catching up and has now been found even in archaea, with its function in osmotic homeostasis being conserved across kingdom boundaries. Small modules associated with mobile genetic elements, which make and react to numerous novel mixed cyclic dinucleotides, seem to roam around rather freely in the bacterial world. Finally, many novel and old nucleotide molecules are still lurking around in search of a function. Across many talks it became apparent that (p)ppGpp, c-di-GMP and GTP/ATP can share and compete for binding sites (e.g., the Walker A motif in GTP/ATPases) with intriguing regulatory consequences, thus contributing to the emergent trend of systemwide networks that interconnect diverse signaling nucleotides. Overall, this inspiring conference made it clear that second messenger signaling is currently one of the most dynamic and exciting areas in microbial molecular biology and physiology, with major impacts ranging from microbial systems biology and ecology to infection biology.
KW - biofilm
KW - c-di-AMP
KW - c-di-GMP
KW - cGAMP
KW - ppGpp
UR - http://www.scopus.com/inward/record.url?scp=85061280077&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2019.01.014
DO - 10.1016/j.jmb.2019.01.014
M3 - Article
C2 - 30668970
AN - SCOPUS:85061280077
VL - 431
SP - 908
EP - 927
JO - Journal of molecular biology
JF - Journal of molecular biology
SN - 0022-2836
IS - 5
ER -