Details
| Original language | English |
|---|---|
| Pages (from-to) | 1291-1301 |
| Number of pages | 11 |
| Journal | Journal of the American Society for Mass Spectrometry |
| Volume | 31 |
| Issue number | 6 |
| Early online date | 6 May 2020 |
| Publication status | Published - 3 Jun 2020 |
Abstract
In contrast to classical Ion Mobility Spectrometers (IMS) operating at ambient pressure, the High Kinetic Energy Ion Mobility Spectrometer (HiKE-IMS) is operated at reduced pressures of between 10 and 40 mbar and higher reduced electric field strengths of up to 120 Td. Thus, the ion-molecule reactions occurring in the HiKE-IMS can significantly differ from those in classical ambient pressure IMS. In order to predict the ionization pathways of specific analyte molecules, profound knowledge of the reactant ion species generated in HiKE-IMS and their dependence on the ionization conditions is essential. In this work, the formation of positive reactant ions in HiKE-IMS is investigated in detail. On the basis of kinetic and thermodynamic data from the literature, the ion-molecule reactions are kinetically modeled. To verify the model, we present measurements of the reactant ion population and its dependence on the reduced electric field strength, the operating pressure, and the water concentration in the sample gas. All of these parameters significantly affect the reactant ion population formed in HiKE-IMS.
Keywords
- corona discharge ionization, high kinetic energy ion mobility spectrometry, HiKE-IMS, IMS, ion mobility spectrometry, kinetic modeling, positive reactant ion formation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Structural Biology
- Chemistry(all)
- Spectroscopy
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In: Journal of the American Society for Mass Spectrometry, Vol. 31, No. 6, 03.06.2020, p. 1291-1301.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Positive Reactant Ion Formation in High Kinetic Energy Ion Mobility Spectrometry (HiKE-IMS)
AU - Allers, Maria
AU - Kirk, Ansgar Thomas
AU - Eckermann, Manuel
AU - Schaefer, Christoph
AU - Erdogdu, Duygu
AU - Wissdorf, Walter
AU - Benter, Thorsten
AU - Zimmermann, Stefan
N1 - Funding Information: This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), joint project BE 2124/8-1-ZI 1288/8-1
PY - 2020/6/3
Y1 - 2020/6/3
N2 - In contrast to classical Ion Mobility Spectrometers (IMS) operating at ambient pressure, the High Kinetic Energy Ion Mobility Spectrometer (HiKE-IMS) is operated at reduced pressures of between 10 and 40 mbar and higher reduced electric field strengths of up to 120 Td. Thus, the ion-molecule reactions occurring in the HiKE-IMS can significantly differ from those in classical ambient pressure IMS. In order to predict the ionization pathways of specific analyte molecules, profound knowledge of the reactant ion species generated in HiKE-IMS and their dependence on the ionization conditions is essential. In this work, the formation of positive reactant ions in HiKE-IMS is investigated in detail. On the basis of kinetic and thermodynamic data from the literature, the ion-molecule reactions are kinetically modeled. To verify the model, we present measurements of the reactant ion population and its dependence on the reduced electric field strength, the operating pressure, and the water concentration in the sample gas. All of these parameters significantly affect the reactant ion population formed in HiKE-IMS.
AB - In contrast to classical Ion Mobility Spectrometers (IMS) operating at ambient pressure, the High Kinetic Energy Ion Mobility Spectrometer (HiKE-IMS) is operated at reduced pressures of between 10 and 40 mbar and higher reduced electric field strengths of up to 120 Td. Thus, the ion-molecule reactions occurring in the HiKE-IMS can significantly differ from those in classical ambient pressure IMS. In order to predict the ionization pathways of specific analyte molecules, profound knowledge of the reactant ion species generated in HiKE-IMS and their dependence on the ionization conditions is essential. In this work, the formation of positive reactant ions in HiKE-IMS is investigated in detail. On the basis of kinetic and thermodynamic data from the literature, the ion-molecule reactions are kinetically modeled. To verify the model, we present measurements of the reactant ion population and its dependence on the reduced electric field strength, the operating pressure, and the water concentration in the sample gas. All of these parameters significantly affect the reactant ion population formed in HiKE-IMS.
KW - corona discharge ionization
KW - high kinetic energy ion mobility spectrometry
KW - HiKE-IMS
KW - IMS
KW - ion mobility spectrometry
KW - kinetic modeling
KW - positive reactant ion formation
UR - http://www.scopus.com/inward/record.url?scp=85085905401&partnerID=8YFLogxK
U2 - 10.1021/jasms.0c00114
DO - 10.1021/jasms.0c00114
M3 - Article
C2 - 32372646
VL - 31
SP - 1291
EP - 1301
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
SN - 1044-0305
IS - 6
ER -