Details
| Original language | English |
|---|---|
| Pages (from-to) | 2175-2199 |
| Number of pages | 25 |
| Journal | Natural product reports |
| Volume | 39 |
| Issue number | 11 |
| Publication status | Published - 23 Sept 2022 |
Abstract
Covering: up to 2022 The report provides a broad approach to deciphering the evolution of coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect to the coenzymes required for this purpose. Coenzymes whose biosynthesis relies on a large number of coenzyme-mediated reactions probably appeared on the scene at a later stage of biological evolution, whereas the biosyntheses of pyridoxal phosphate (PLP) and nicotinamide (NAD+) require little additional coenzymatic support and are therefore most likely very ancient biosynthetic pathways.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, Vol. 39, No. 11, 23.09.2022, p. 2175-2199.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - On the evolution of coenzyme biosynthesis
AU - Kirschning, Andreas
PY - 2022/9/23
Y1 - 2022/9/23
N2 - Covering: up to 2022 The report provides a broad approach to deciphering the evolution of coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect to the coenzymes required for this purpose. Coenzymes whose biosynthesis relies on a large number of coenzyme-mediated reactions probably appeared on the scene at a later stage of biological evolution, whereas the biosyntheses of pyridoxal phosphate (PLP) and nicotinamide (NAD+) require little additional coenzymatic support and are therefore most likely very ancient biosynthetic pathways.
AB - Covering: up to 2022 The report provides a broad approach to deciphering the evolution of coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect to the coenzymes required for this purpose. Coenzymes whose biosynthesis relies on a large number of coenzyme-mediated reactions probably appeared on the scene at a later stage of biological evolution, whereas the biosyntheses of pyridoxal phosphate (PLP) and nicotinamide (NAD+) require little additional coenzymatic support and are therefore most likely very ancient biosynthetic pathways.
UR - http://www.scopus.com/inward/record.url?scp=85139950738&partnerID=8YFLogxK
U2 - 10.1039/d2np00037g
DO - 10.1039/d2np00037g
M3 - Review article
AN - SCOPUS:85139950738
VL - 39
SP - 2175
EP - 2199
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
IS - 11
ER -