Details
| Original language | English |
|---|---|
| Pages (from-to) | 1-19 |
| Number of pages | 19 |
| Journal | Advances in Colloid and Interface Science |
| Volume | 245 |
| Publication status | Published - 4 May 2017 |
| Externally published | Yes |
Abstract
Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.
Keywords
- Computed tomography, Magnetic resonance imaging, Photoluminescent imaging, Positron emission tomography, Single-photon emission computed tomography, Upconversion nanoparticles
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Surfaces and Interfaces
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemical Engineering(all)
- Colloid and Surface Chemistry
Sustainable Development Goals
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In: Advances in Colloid and Interface Science, Vol. 245, 04.05.2017, p. 1-19.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques
AU - Generalova, A. N.
AU - Chichkov, B. N.
AU - Khaydukov, E. V.
N1 - Funding information: Chichkov B.N. would like to acknowledge Russian Science Foundation [RSCF grant ? 16-13-10528], Generalova A.N., Khaydukov E.V. acknowledge financial support from Russian Foundation for Basic Research [RFBR grant ? 17-03-01033].
PY - 2017/5/4
Y1 - 2017/5/4
N2 - Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.
AB - Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.
KW - Computed tomography
KW - Magnetic resonance imaging
KW - Photoluminescent imaging
KW - Positron emission tomography
KW - Single-photon emission computed tomography
KW - Upconversion nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85019069529&partnerID=8YFLogxK
U2 - 10.1016/j.cis.2017.05.006
DO - 10.1016/j.cis.2017.05.006
M3 - Review article
C2 - 28499601
AN - SCOPUS:85019069529
VL - 245
SP - 1
EP - 19
JO - Advances in Colloid and Interface Science
JF - Advances in Colloid and Interface Science
SN - 0001-8686
ER -