Details
| Original language | English |
|---|---|
| Article number | 118421 |
| Journal | Biomedicine and Pharmacotherapy |
| Volume | 191 |
| Early online date | 12 Aug 2025 |
| Publication status | Published - Oct 2025 |
Abstract
Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder described by chronic hyperglycemia, insulin resistance, as well as low-grade inflammation. Recent research highlights the vital role of the gut microbiota in the pathogenesis and progression of T2DM. Dysbiosis can impair intestinal barrier integrity, promote systemic inflammation, and contribute to insulin resistance and glucose metabolism dysfunction. This review article investigates the mechanisms by which probiotics interact with gut microbiota and host signaling pathways to impact the onset and complications of T2DM. Databases were searched, and related articles were added, to get a thorough overview of the relationship between probiotics and T2DM and its complications. Probiotics have appeared as potential modulators of the gut microbiome, capable of restoring microbial balance and strengthening intestinal barrier function. Probiotics can influence glucose homeostasis through their multifaceted effects on the gut microbiota and host metabolism. Through the production of beneficial metabolites, suppress α-glucosidase activity, enhance short-chain fatty acid (SCFA) levels, competitive inhibition of pathogenic bacteria, regulation of gut-derived neurotransmitters such as serotonin, improve intestinal, and immune functions, probiotics may alleviate key mechanisms involved in T2DM development and its complications.
Keywords
- Diabetic complications, Dysbiosis, Gut microbiota, Intestinal barrier, Probiotics, Type 2 diabetes
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
Sustainable Development Goals
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In: Biomedicine and Pharmacotherapy, Vol. 191, 118421, 10.2025.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Mechanism of actions of probiotics on type 2 diabetes
T2 - Development and complications
AU - Ağagündüz, Duygu
AU - Çelik, Elif
AU - Cemali, Özge
AU - Yesildemir, Ozge
AU - Demirci, Kezban Şahin
AU - Akkus, Gamze
AU - Esatbeyoglu, Tuba
AU - Ozogul, Fatih
N1 - Publisher Copyright: © 2025 The Authors
PY - 2025/10
Y1 - 2025/10
N2 - Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder described by chronic hyperglycemia, insulin resistance, as well as low-grade inflammation. Recent research highlights the vital role of the gut microbiota in the pathogenesis and progression of T2DM. Dysbiosis can impair intestinal barrier integrity, promote systemic inflammation, and contribute to insulin resistance and glucose metabolism dysfunction. This review article investigates the mechanisms by which probiotics interact with gut microbiota and host signaling pathways to impact the onset and complications of T2DM. Databases were searched, and related articles were added, to get a thorough overview of the relationship between probiotics and T2DM and its complications. Probiotics have appeared as potential modulators of the gut microbiome, capable of restoring microbial balance and strengthening intestinal barrier function. Probiotics can influence glucose homeostasis through their multifaceted effects on the gut microbiota and host metabolism. Through the production of beneficial metabolites, suppress α-glucosidase activity, enhance short-chain fatty acid (SCFA) levels, competitive inhibition of pathogenic bacteria, regulation of gut-derived neurotransmitters such as serotonin, improve intestinal, and immune functions, probiotics may alleviate key mechanisms involved in T2DM development and its complications.
AB - Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder described by chronic hyperglycemia, insulin resistance, as well as low-grade inflammation. Recent research highlights the vital role of the gut microbiota in the pathogenesis and progression of T2DM. Dysbiosis can impair intestinal barrier integrity, promote systemic inflammation, and contribute to insulin resistance and glucose metabolism dysfunction. This review article investigates the mechanisms by which probiotics interact with gut microbiota and host signaling pathways to impact the onset and complications of T2DM. Databases were searched, and related articles were added, to get a thorough overview of the relationship between probiotics and T2DM and its complications. Probiotics have appeared as potential modulators of the gut microbiome, capable of restoring microbial balance and strengthening intestinal barrier function. Probiotics can influence glucose homeostasis through their multifaceted effects on the gut microbiota and host metabolism. Through the production of beneficial metabolites, suppress α-glucosidase activity, enhance short-chain fatty acid (SCFA) levels, competitive inhibition of pathogenic bacteria, regulation of gut-derived neurotransmitters such as serotonin, improve intestinal, and immune functions, probiotics may alleviate key mechanisms involved in T2DM development and its complications.
KW - Diabetic complications
KW - Dysbiosis
KW - Gut microbiota
KW - Intestinal barrier
KW - Probiotics
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=105012773217&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2025.118421
DO - 10.1016/j.biopha.2025.118421
M3 - Review article
AN - SCOPUS:105012773217
VL - 191
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
M1 - 118421
ER -