Details
| Original language | English |
|---|---|
| Article number | 100380 |
| Journal | SLAS Technology |
| Volume | 36 |
| Early online date | 4 Dec 2025 |
| Publication status | Published - Jan 2026 |
Abstract
Laboratory digitalization is a complex field that includes many aspects to consider, such as device control, data management, and data evaluation. This article presents a potential laboratory digitalization process, including the use of open-source software and hardware components from laboratory equipment to data evaluation. It shows what is required and how it can be used. In this example, a SiLA-based continuous chromatography system is used as a model device to demonstrate the possible purification of GFP from crude cell lysate. The current version of the Gateway Module is a translation unit for driver protocols used for device control. It uses SiLA-based drivers within a Docker environment to communicate with the server infrastructure. The Gateway Module software was managed and rolled out with the mkbox-project. Finally, the recorded laboratory data are stored in a data management system and made available for later analysis. The article also discusses how software and hardware are maintained in the background, as well as the update strategy used.
Keywords
- Gateway module, Labor digitalization, PCCC, SiLA 2
ASJC Scopus subject areas
- Computer Science(all)
- Computer Science Applications
- Health Professions(all)
- Medical Laboratory Technology
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In: SLAS Technology, Vol. 36, 100380, 01.2026.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Implementation of a modular digital laboratory infrastructure for SiLA 2 based devices
AU - Lange, Ferdinand
AU - Habich, Tessa
AU - Beutel, Sascha
N1 - Publisher Copyright: © 2025 The Authors
PY - 2026/1
Y1 - 2026/1
N2 - Laboratory digitalization is a complex field that includes many aspects to consider, such as device control, data management, and data evaluation. This article presents a potential laboratory digitalization process, including the use of open-source software and hardware components from laboratory equipment to data evaluation. It shows what is required and how it can be used. In this example, a SiLA-based continuous chromatography system is used as a model device to demonstrate the possible purification of GFP from crude cell lysate. The current version of the Gateway Module is a translation unit for driver protocols used for device control. It uses SiLA-based drivers within a Docker environment to communicate with the server infrastructure. The Gateway Module software was managed and rolled out with the mkbox-project. Finally, the recorded laboratory data are stored in a data management system and made available for later analysis. The article also discusses how software and hardware are maintained in the background, as well as the update strategy used.
AB - Laboratory digitalization is a complex field that includes many aspects to consider, such as device control, data management, and data evaluation. This article presents a potential laboratory digitalization process, including the use of open-source software and hardware components from laboratory equipment to data evaluation. It shows what is required and how it can be used. In this example, a SiLA-based continuous chromatography system is used as a model device to demonstrate the possible purification of GFP from crude cell lysate. The current version of the Gateway Module is a translation unit for driver protocols used for device control. It uses SiLA-based drivers within a Docker environment to communicate with the server infrastructure. The Gateway Module software was managed and rolled out with the mkbox-project. Finally, the recorded laboratory data are stored in a data management system and made available for later analysis. The article also discusses how software and hardware are maintained in the background, as well as the update strategy used.
KW - Gateway module
KW - Labor digitalization
KW - PCCC
KW - SiLA 2
UR - http://www.scopus.com/inward/record.url?scp=105023830555&partnerID=8YFLogxK
U2 - 10.1016/j.slast.2025.100380
DO - 10.1016/j.slast.2025.100380
M3 - Article
C2 - 41352421
AN - SCOPUS:105023830555
VL - 36
JO - SLAS Technology
JF - SLAS Technology
SN - 2472-6303
M1 - 100380
ER -