Details
| Original language | English |
|---|---|
| Article number | 1004 |
| Journal | NUTRIENTS |
| Volume | 12 |
| Issue number | 4 |
| Publication status | Published - 5 Apr 2020 |
Abstract
Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.
Keywords
- Endurance athletes, Exercise, Metabolic regulation, Sirtuins, Vegan, Vegetarian
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Food Science
- Nursing(all)
- Nutrition and Dietetics
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: NUTRIENTS, Vol. 12, No. 4, 1004, 05.04.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Impact of nutrition on short-term exercise-induced sirtuin regulation
T2 - Vegans differ from omnivores and LACTO-OVO vegetarians
AU - Potthast, Arne Björn
AU - Nebl, Josefine
AU - Wasserfurth, Paulina
AU - Haufe, S.
AU - Eigendorf, J.
AU - Hahn, Andreas
AU - Das, Anibh
N1 - Funding information: Financial funding for sirtuin analyses by Vitaflo Int. Ltd.
PY - 2020/4/5
Y1 - 2020/4/5
N2 - Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.
AB - Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.
KW - Endurance athletes
KW - Exercise
KW - Metabolic regulation
KW - Sirtuins
KW - Vegan
KW - Vegetarian
UR - http://www.scopus.com/inward/record.url?scp=85083023168&partnerID=8YFLogxK
U2 - 10.3390/nu12041004
DO - 10.3390/nu12041004
M3 - Article
C2 - 32260570
VL - 12
JO - NUTRIENTS
JF - NUTRIENTS
SN - 2072-6643
IS - 4
M1 - 1004
ER -