Details
| Original language | English |
|---|---|
| Pages (from-to) | 22-28 |
| Number of pages | 7 |
| Journal | Prostaglandins Leukotrienes and Essential Fatty Acids |
| Volume | 109 |
| Issue number | 6 |
| Publication status | Published - Jun 2016 |
Abstract
INTRODUCTION: During pregnancy and lactation, there is a high need of long-chain (LC) omega-3 fatty acids (n-3 PUFA), especially docosahexaenoic acid (DHA), for fetus and infant. Also, a low LC n-3 PUFA status during pregnancy is associated with postpartum depression. The aim of this cross-sectional study was to analyze the LC n-3 PUFA status in German women during pregnancy and lactation.
MATERIAL AND METHODS: As a part of a nationwide cross-sectional study in which the nutrient status of women in different stages of life was determined, 213 pregnant (≥27th week of gestation) and 127 lactating women between 18 and 44 years were evaluated regarding their LC n-3 PUFA status by measuring the omega-3 index (relative eicosapentaenoic acid (EPA) and DHA concentration in erythrocyte fatty acid).
RESULTS: The mean omega-3 index of the total study population was 6.23±1.48%. Pregnant women showed significant (p≤0.001) higher omega-3 index values (6.40±1.31%) and DHA concentrations (5.91±1.23%) than lactating women (omega-3 index: 5.50±1.34%; DHA: 4.79±1.27%). Woman with LC n-3 PUFA supplementation showed higher omega-3 index values (7.73±1.28%) vs. women without supplementation (6.04±1.39%, p≤0.001). Week of pregnancy, month of lactation as well as smoking were negatively associated with the omega-3 index.
CONCLUSION: Comprehensive data on the long-term LC n-3 PUFA status of German women during pregnancy and lactation are presented. To evaluate an optimal maternal omega-3 index in view of the fetal and infant development further studies are needed.
Keywords
- Adult, Cross-Sectional Studies, Dietary Supplements, Docosahexaenoic Acids/blood, Eicosapentaenoic Acid/blood, Fatty Acids, Omega-3/analysis, Female, Germany, Humans, Lactation/blood, Pregnancy, Young Adult, LC n-3 PUFA, Lactation, Omega-3 index, DHA
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Clinical Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
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In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 109, No. 6, 06.2016, p. 22-28.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Higher omega-3 index and DHA status in pregnant women compared to lactating women - Results from a German nation-wide cross-sectional study
AU - Gellert, Sandra
AU - Schuchardt, Jan Philipp
AU - Hahn, Andreas
N1 - Funding information: Study was supported by Rottapharm Madaus GmbH (Cologne, Germany) – now a part of Meda AB (Bad Homburg, Germany).
PY - 2016/6
Y1 - 2016/6
N2 - INTRODUCTION: During pregnancy and lactation, there is a high need of long-chain (LC) omega-3 fatty acids (n-3 PUFA), especially docosahexaenoic acid (DHA), for fetus and infant. Also, a low LC n-3 PUFA status during pregnancy is associated with postpartum depression. The aim of this cross-sectional study was to analyze the LC n-3 PUFA status in German women during pregnancy and lactation.MATERIAL AND METHODS: As a part of a nationwide cross-sectional study in which the nutrient status of women in different stages of life was determined, 213 pregnant (≥27th week of gestation) and 127 lactating women between 18 and 44 years were evaluated regarding their LC n-3 PUFA status by measuring the omega-3 index (relative eicosapentaenoic acid (EPA) and DHA concentration in erythrocyte fatty acid).RESULTS: The mean omega-3 index of the total study population was 6.23±1.48%. Pregnant women showed significant (p≤0.001) higher omega-3 index values (6.40±1.31%) and DHA concentrations (5.91±1.23%) than lactating women (omega-3 index: 5.50±1.34%; DHA: 4.79±1.27%). Woman with LC n-3 PUFA supplementation showed higher omega-3 index values (7.73±1.28%) vs. women without supplementation (6.04±1.39%, p≤0.001). Week of pregnancy, month of lactation as well as smoking were negatively associated with the omega-3 index.CONCLUSION: Comprehensive data on the long-term LC n-3 PUFA status of German women during pregnancy and lactation are presented. To evaluate an optimal maternal omega-3 index in view of the fetal and infant development further studies are needed.
AB - INTRODUCTION: During pregnancy and lactation, there is a high need of long-chain (LC) omega-3 fatty acids (n-3 PUFA), especially docosahexaenoic acid (DHA), for fetus and infant. Also, a low LC n-3 PUFA status during pregnancy is associated with postpartum depression. The aim of this cross-sectional study was to analyze the LC n-3 PUFA status in German women during pregnancy and lactation.MATERIAL AND METHODS: As a part of a nationwide cross-sectional study in which the nutrient status of women in different stages of life was determined, 213 pregnant (≥27th week of gestation) and 127 lactating women between 18 and 44 years were evaluated regarding their LC n-3 PUFA status by measuring the omega-3 index (relative eicosapentaenoic acid (EPA) and DHA concentration in erythrocyte fatty acid).RESULTS: The mean omega-3 index of the total study population was 6.23±1.48%. Pregnant women showed significant (p≤0.001) higher omega-3 index values (6.40±1.31%) and DHA concentrations (5.91±1.23%) than lactating women (omega-3 index: 5.50±1.34%; DHA: 4.79±1.27%). Woman with LC n-3 PUFA supplementation showed higher omega-3 index values (7.73±1.28%) vs. women without supplementation (6.04±1.39%, p≤0.001). Week of pregnancy, month of lactation as well as smoking were negatively associated with the omega-3 index.CONCLUSION: Comprehensive data on the long-term LC n-3 PUFA status of German women during pregnancy and lactation are presented. To evaluate an optimal maternal omega-3 index in view of the fetal and infant development further studies are needed.
KW - Adult
KW - Cross-Sectional Studies
KW - Dietary Supplements
KW - Docosahexaenoic Acids/blood
KW - Eicosapentaenoic Acid/blood
KW - Fatty Acids, Omega-3/analysis
KW - Female
KW - Germany
KW - Humans
KW - Lactation/blood
KW - Pregnancy
KW - Young Adult
KW - LC n-3 PUFA
KW - Lactation
KW - Omega-3 index
KW - DHA
UR - http://www.scopus.com/inward/record.url?scp=84964545740&partnerID=8YFLogxK
U2 - 10.1016/j.plefa.2016.04.002
DO - 10.1016/j.plefa.2016.04.002
M3 - Article
C2 - 27269710
VL - 109
SP - 22
EP - 28
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
SN - 0952-3278
IS - 6
ER -