Free radical scavenging and cellular antioxidant properties of astaxanthin

Research output: Contribution to journalArticleResearchpeer review

Authors

  • J. Dose
  • S. Matsugo
  • H. Yokokawa
  • Y. Koshida
  • S. Okazaki
  • U. Seidel
  • M. Eggersdorfer
  • G. Rimbach
  • T. Esatbeyoglu
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Details

Original languageEnglish
Article number103
JournalInternational Journal of Molecular Sciences
Volume17
Issue number1
Publication statusPublished - 14 Jan 2016

Abstract

Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.

Keywords

    Antioxidant, Astaxanthin, Electron spin resonance spectroscopy, Free radical scavenging

ASJC Scopus subject areas

Sustainable Development Goals

Cite this

Free radical scavenging and cellular antioxidant properties of astaxanthin. / Dose, J.; Matsugo, S.; Yokokawa, H. et al.
In: International Journal of Molecular Sciences, Vol. 17, No. 1, 103, 14.01.2016.

Research output: Contribution to journalArticleResearchpeer review

Dose, J, Matsugo, S, Yokokawa, H, Koshida, Y, Okazaki, S, Seidel, U, Eggersdorfer, M, Rimbach, G & Esatbeyoglu, T 2016, 'Free radical scavenging and cellular antioxidant properties of astaxanthin', International Journal of Molecular Sciences, vol. 17, no. 1, 103. https://doi.org/10.3390/ijms17010103
Dose, J., Matsugo, S., Yokokawa, H., Koshida, Y., Okazaki, S., Seidel, U., Eggersdorfer, M., Rimbach, G., & Esatbeyoglu, T. (2016). Free radical scavenging and cellular antioxidant properties of astaxanthin. International Journal of Molecular Sciences, 17(1), Article 103. https://doi.org/10.3390/ijms17010103
Dose J, Matsugo S, Yokokawa H, Koshida Y, Okazaki S, Seidel U et al. Free radical scavenging and cellular antioxidant properties of astaxanthin. International Journal of Molecular Sciences. 2016 Jan 14;17(1):103. doi: 10.3390/ijms17010103
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abstract = "Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.",
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AU - Matsugo, S.

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AU - Koshida, Y.

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AU - Seidel, U.

AU - Eggersdorfer, M.

AU - Rimbach, G.

AU - Esatbeyoglu, T.

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