Details
| Original language | English |
|---|---|
| Pages (from-to) | 22932-22938 |
| Number of pages | 7 |
| Journal | Analytical chemistry |
| Volume | 97 |
| Issue number | 41 |
| Early online date | 7 Oct 2025 |
| Publication status | Published - 21 Oct 2025 |
Abstract
This study presents the first coupling of high-throughput droplet microfluidics to an ultra-fast ion mobility spectrometer (IMS), providing a method for the label-free and comprehensive analysis of droplet contents at very high speeds. Building on the core strengths of IMS ─ compactness, simplicity, and cost-effectiveness ─ the added ability to capture full spectra at exceptionally short cycle times of less than 2 ms positions the technique as an exceptional platform for spectrometric analysis. The combination of a custom electrospray interface, a purpose-built monolithic fused-silica droplet generator chip, and an ultra-fast IMS enabled the chemical analysis of individual droplets in segmented flow at speeds of up to 120 Hz. The approach of droplet-based high-throughput ion mobility spectrometry (DHT-IMS) was also applied for reaction screening in nanoliter-sized droplets, exemplified by a hydrazone formation reaction between 5-methylisatin and phenylhydrazine.
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
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In: Analytical chemistry, Vol. 97, No. 41, 21.10.2025, p. 22932-22938.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Fast Chemical Analysis of Droplets Unlocked by Ultra-Fast Ion Mobility Spectrometry
AU - Welters, Klaus
AU - Thoben, Christian
AU - Schwieger, Julius
AU - Nitschke, Alexander
AU - Ostermeier, Tim
AU - Zimmermann, Stefan
AU - Belder, Detlev
N1 - Publisher Copyright: © 2025 The Authors. Published by American Chemical Society
PY - 2025/10/21
Y1 - 2025/10/21
N2 - This study presents the first coupling of high-throughput droplet microfluidics to an ultra-fast ion mobility spectrometer (IMS), providing a method for the label-free and comprehensive analysis of droplet contents at very high speeds. Building on the core strengths of IMS ─ compactness, simplicity, and cost-effectiveness ─ the added ability to capture full spectra at exceptionally short cycle times of less than 2 ms positions the technique as an exceptional platform for spectrometric analysis. The combination of a custom electrospray interface, a purpose-built monolithic fused-silica droplet generator chip, and an ultra-fast IMS enabled the chemical analysis of individual droplets in segmented flow at speeds of up to 120 Hz. The approach of droplet-based high-throughput ion mobility spectrometry (DHT-IMS) was also applied for reaction screening in nanoliter-sized droplets, exemplified by a hydrazone formation reaction between 5-methylisatin and phenylhydrazine.
AB - This study presents the first coupling of high-throughput droplet microfluidics to an ultra-fast ion mobility spectrometer (IMS), providing a method for the label-free and comprehensive analysis of droplet contents at very high speeds. Building on the core strengths of IMS ─ compactness, simplicity, and cost-effectiveness ─ the added ability to capture full spectra at exceptionally short cycle times of less than 2 ms positions the technique as an exceptional platform for spectrometric analysis. The combination of a custom electrospray interface, a purpose-built monolithic fused-silica droplet generator chip, and an ultra-fast IMS enabled the chemical analysis of individual droplets in segmented flow at speeds of up to 120 Hz. The approach of droplet-based high-throughput ion mobility spectrometry (DHT-IMS) was also applied for reaction screening in nanoliter-sized droplets, exemplified by a hydrazone formation reaction between 5-methylisatin and phenylhydrazine.
UR - http://www.scopus.com/inward/record.url?scp=105019080259&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.5c05025
DO - 10.1021/acs.analchem.5c05025
M3 - Article
AN - SCOPUS:105019080259
VL - 97
SP - 22932
EP - 22938
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 41
ER -