Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Annabel C. Murphy
  • Daisuke Fukuda
  • Zhongshu Song
  • Joanne Hothersall
  • Russell J. Cox
  • Christine L. Willis
  • Christopher M. Thomas
  • Thomas J. Simpson

External Research Organisations

  • University of Bristol
  • University of Birmingham
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Details

Original languageEnglish
Pages (from-to)3271-3274
Number of pages4
JournalAngewandte Chemie
Volume50
Issue number14
Publication statusPublished - 28 Mar 2011
Externally publishedYes

Abstract

New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.

Keywords

    antibiotics, biosynthesis, methicillin resistance, mupirocin, thiomarinol

ASJC Scopus subject areas

Sustainable Development Goals

Cite this

Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390. / Murphy, Annabel C.; Fukuda, Daisuke; Song, Zhongshu et al.
In: Angewandte Chemie , Vol. 50, No. 14, 28.03.2011, p. 3271-3274.

Research output: Contribution to journalArticleResearchpeer review

Murphy AC, Fukuda D, Song Z, Hothersall J, Cox RJ, Willis CL et al. Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390. Angewandte Chemie . 2011 Mar 28;50(14):3271-3274. doi: 10.1002/anie.201007029, 10.1002/ange.201007029
Murphy, Annabel C. ; Fukuda, Daisuke ; Song, Zhongshu et al. / Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390. In: Angewandte Chemie . 2011 ; Vol. 50, No. 14. pp. 3271-3274.
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