Details
| Original language | English |
|---|---|
| Pages (from-to) | 869-877 |
| Number of pages | 9 |
| Journal | Journal of Nutrition, Health & Aging |
| Volume | 25 |
| Issue number | 7 |
| Early online date | 13 Apr 2021 |
| Publication status | Published - Jul 2021 |
Abstract
Objectives: The intima-media thickness of the common carotid artery (ccIMT) is an established risk marker for cardiovascular disease (CVD). However, it is unclear whether lifestyle interventions can easily demonstrate an improvement in ccIMT. The objective was to test if our intervention would beneficially affect ccIMT (among other CVD markers). Design: Non-randomized controlled trial Setting: Rural northwest Germany Participants: Middle-aged and elderly participants from the general population (intervention: n = 114; control: n = 87) Intervention: A community-based, 6-month controlled lifestyle intervention focusing on four areas of lifestyle change: a plant-based diet, physical activity, stress management, and an improved social life. A strong emphasis was on dietary change. Measurements: We tested whether ccIMT change from baseline to 6 months was different between groups. Results: With all participants included, no significant difference in mean ccIMT change between groups was observed (p = 0.708). However, in a subgroup analysis with participants with high baseline mean ccIMT (≥0.800 mm) a significant difference in mean ccIMT change between intervention (−0.023 [95% CI −0.052, 0.007] mm; n = 22; baseline mean ccIMT: 0.884 ± 0.015 mm) and control (0.041 [95% CI 0.009, 0.073] mm; n = 13; baseline mean ccIMT: 0.881 ± 0.022 mm) was observed (p = 0.004). Adjusting for potential confounders did not substantially alter the results. Conclusion: The results indicate that healthy lifestyle changes can beneficially affect ccIMT within 6 months and that such a beneficial effect may be more easily demonstrated if participants with high baseline ccIMT are recruited. The observed effect is of relevance for the prevention of CVD events, including myocardial infarction and stroke.
Keywords
- Plant-based diet, cardiovascular disease, cardiovascular health, healthy aging, preventive medicine
ASJC Scopus subject areas
- Medicine(all)
- Medicine (miscellaneous)
- Nursing(all)
- Nutrition and Dietetics
- Medicine(all)
- Geriatrics and Gerontology
Sustainable Development Goals
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In: Journal of Nutrition, Health & Aging, Vol. 25, No. 7, 07.2021, p. 869-877.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Effect of a 6-Month Controlled Lifestyle Intervention on Common Carotid Intima-Media Thickness
AU - Koeder, Christian
AU - Hahn, Andreas
AU - Englert, H.
N1 - Funding Information: This work was conducted as part of the project “münster.land.leben” and was funded by the German Federal Ministry of Education and Research (BMBF) and the Joint Science Conference (GWK) within the programme “Innovative Hochschule” (grant number: 03IHS062A). Heike Englert reports a grant from the German Federal Ministry of Education and Research (BMBF) during the conduct of the study. Christian Koeder and Andreas Hahn have nothing to disclose.
PY - 2021/7
Y1 - 2021/7
N2 - Objectives: The intima-media thickness of the common carotid artery (ccIMT) is an established risk marker for cardiovascular disease (CVD). However, it is unclear whether lifestyle interventions can easily demonstrate an improvement in ccIMT. The objective was to test if our intervention would beneficially affect ccIMT (among other CVD markers). Design: Non-randomized controlled trial Setting: Rural northwest Germany Participants: Middle-aged and elderly participants from the general population (intervention: n = 114; control: n = 87) Intervention: A community-based, 6-month controlled lifestyle intervention focusing on four areas of lifestyle change: a plant-based diet, physical activity, stress management, and an improved social life. A strong emphasis was on dietary change. Measurements: We tested whether ccIMT change from baseline to 6 months was different between groups. Results: With all participants included, no significant difference in mean ccIMT change between groups was observed (p = 0.708). However, in a subgroup analysis with participants with high baseline mean ccIMT (≥0.800 mm) a significant difference in mean ccIMT change between intervention (−0.023 [95% CI −0.052, 0.007] mm; n = 22; baseline mean ccIMT: 0.884 ± 0.015 mm) and control (0.041 [95% CI 0.009, 0.073] mm; n = 13; baseline mean ccIMT: 0.881 ± 0.022 mm) was observed (p = 0.004). Adjusting for potential confounders did not substantially alter the results. Conclusion: The results indicate that healthy lifestyle changes can beneficially affect ccIMT within 6 months and that such a beneficial effect may be more easily demonstrated if participants with high baseline ccIMT are recruited. The observed effect is of relevance for the prevention of CVD events, including myocardial infarction and stroke.
AB - Objectives: The intima-media thickness of the common carotid artery (ccIMT) is an established risk marker for cardiovascular disease (CVD). However, it is unclear whether lifestyle interventions can easily demonstrate an improvement in ccIMT. The objective was to test if our intervention would beneficially affect ccIMT (among other CVD markers). Design: Non-randomized controlled trial Setting: Rural northwest Germany Participants: Middle-aged and elderly participants from the general population (intervention: n = 114; control: n = 87) Intervention: A community-based, 6-month controlled lifestyle intervention focusing on four areas of lifestyle change: a plant-based diet, physical activity, stress management, and an improved social life. A strong emphasis was on dietary change. Measurements: We tested whether ccIMT change from baseline to 6 months was different between groups. Results: With all participants included, no significant difference in mean ccIMT change between groups was observed (p = 0.708). However, in a subgroup analysis with participants with high baseline mean ccIMT (≥0.800 mm) a significant difference in mean ccIMT change between intervention (−0.023 [95% CI −0.052, 0.007] mm; n = 22; baseline mean ccIMT: 0.884 ± 0.015 mm) and control (0.041 [95% CI 0.009, 0.073] mm; n = 13; baseline mean ccIMT: 0.881 ± 0.022 mm) was observed (p = 0.004). Adjusting for potential confounders did not substantially alter the results. Conclusion: The results indicate that healthy lifestyle changes can beneficially affect ccIMT within 6 months and that such a beneficial effect may be more easily demonstrated if participants with high baseline ccIMT are recruited. The observed effect is of relevance for the prevention of CVD events, including myocardial infarction and stroke.
KW - Plant-based diet
KW - cardiovascular disease
KW - cardiovascular health
KW - healthy aging
KW - preventive medicine
UR - http://www.scopus.com/inward/record.url?scp=85104595550&partnerID=8YFLogxK
U2 - 10.1007/s12603-021-1628-0
DO - 10.1007/s12603-021-1628-0
M3 - Article
VL - 25
SP - 869
EP - 877
JO - Journal of Nutrition, Health & Aging
JF - Journal of Nutrition, Health & Aging
SN - 1760-4788
IS - 7
ER -