Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Zhe Liu
  • Zunhao Wang
  • Jannik Guckel
  • Ziba Akbarian
  • Tim j. Seifert
  • Daesung Park
  • Uta Schlickum
  • Rainer Stosch
  • Markus Etzkorn

External Research Organisations

  • National Metrology Institute of Germany (PTB)
View graph of relations

Details

Original languageEnglish
Article number2310955
JournalSMALL
Publication statusPublished - 5 Sept 2024

Abstract

DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.

Keywords

    AuNPs dimer, distance control, DNA origami, on-surface folding, surface enhanced Raman spectroscopy

ASJC Scopus subject areas

Cite this

Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding. / Liu, Zhe; Wang, Zunhao; Guckel, Jannik et al.
In: SMALL, 05.09.2024.

Research output: Contribution to journalArticleResearchpeer review

Liu, Z, Wang, Z, Guckel, J, Akbarian, Z, Seifert, TJ, Park, D, Schlickum, U, Stosch, R & Etzkorn, M 2024, 'Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding', SMALL. https://doi.org/10.1002/smll.202310955
Liu, Z., Wang, Z., Guckel, J., Akbarian, Z., Seifert, T. J., Park, D., Schlickum, U., Stosch, R., & Etzkorn, M. (2024). Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding. SMALL, Article 2310955. https://doi.org/10.1002/smll.202310955
Liu Z, Wang Z, Guckel J, Akbarian Z, Seifert TJ, Park D et al. Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding. SMALL. 2024 Sept 5;2310955. doi: 10.1002/smll.202310955
Liu, Zhe ; Wang, Zunhao ; Guckel, Jannik et al. / Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding. In: SMALL. 2024.
Download
@article{f750730c01fa4cc7a812bf44f46eac76,
title = "Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding",
abstract = "DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.",
keywords = "AuNPs dimer, distance control, DNA origami, on-surface folding, surface enhanced Raman spectroscopy",
author = "Zhe Liu and Zunhao Wang and Jannik Guckel and Ziba Akbarian and Seifert, {Tim j.} and Daesung Park and Uta Schlickum and Rainer Stosch and Markus Etzkorn",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Small published by Wiley-VCH GmbH.",
year = "2024",
month = sep,
day = "5",
doi = "10.1002/smll.202310955",
language = "English",
journal = "SMALL",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",

}

Download

TY - JOUR

T1 - Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding

AU - Liu, Zhe

AU - Wang, Zunhao

AU - Guckel, Jannik

AU - Akbarian, Ziba

AU - Seifert, Tim j.

AU - Park, Daesung

AU - Schlickum, Uta

AU - Stosch, Rainer

AU - Etzkorn, Markus

N1 - Publisher Copyright: © 2024 The Authors. Small published by Wiley-VCH GmbH.

PY - 2024/9/5

Y1 - 2024/9/5

N2 - DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.

AB - DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.

KW - AuNPs dimer

KW - distance control

KW - DNA origami

KW - on-surface folding

KW - surface enhanced Raman spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85190536183&partnerID=8YFLogxK

U2 - 10.1002/smll.202310955

DO - 10.1002/smll.202310955

M3 - Article

JO - SMALL

JF - SMALL

SN - 1613-6810

M1 - 2310955

ER -