Details
| Original language | English |
|---|---|
| Article number | 139 |
| Journal | Marine drugs |
| Volume | 23 |
| Issue number | 4 |
| Publication status | Published - 23 Mar 2025 |
Abstract
Obesity increases the risk for insulin resistance (IR) and type-2 diabetes. Lifestyle interventions (LI) and dietary supplementation can help mitigate IR. We investigated the effect of calanus oil (CO) supplementation, combined with LI, on glucose homeostasis in obese subjects. CO, a novel marine oil, contains omega-3 fatty acid wax esters as well as plant sterols and astaxanthin. In the double-blind, randomized, placebo-controlled 12-week intervention study, 266 subjects with distinct IR phenotypes were assigned to four groups: 2 g CO/day, 4 g CO/day, 2 g CO/day + LI, and placebo. The effect of CO on HOMA index reduction was influenced by the initial (t 0) squared HOMA index (interaction p = 0.011). A post hoc test showed significant improvement with 2 g CO/day + LI (estimated marginal means [EMM] 95% confidence interval [CI]: -0.19 [-0.80-0.41], p = 0.021). Secondary analysis revealed that 4 g CO/day had significant effects in subjects with mild IR (HOMA index 2.5-5.0) (EMM [95% CI]: -0.76 [-1.53-0.03], p = 0.043). CO supplementation improved glucose homeostasis, with effects varying by dose, combination with LI, and IR phenotype.
Keywords
- Humans, Insulin Resistance/physiology, Obesity/drug therapy, Female, Double-Blind Method, Male, Middle Aged, Homeostasis/drug effects, Blood Glucose/drug effects, Adult, Dietary Supplements, Life Style, Diabetes Mellitus, Type 2, Fatty Acids, Omega-3/administration & dosage, Animals, lifestyle intervention, calanus firmarchicus, dietary supplements, homeostatic model assessment of insulin resistance
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Sustainable Development Goals
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Marine drugs, Vol. 23, No. 4, 139, 23.03.2025.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Calanus Oil and Lifestyle Interventions Improve Glucose Homeostasis in Obese Subjects with Insulin Resistance
AU - Kerlikowsky, Felix
AU - Bartsch, Madeline
AU - Jonas, Wiebke
AU - Hahn, Andreas
AU - Schuchardt, Jan Philipp
PY - 2025/3/23
Y1 - 2025/3/23
N2 - Obesity increases the risk for insulin resistance (IR) and type-2 diabetes. Lifestyle interventions (LI) and dietary supplementation can help mitigate IR. We investigated the effect of calanus oil (CO) supplementation, combined with LI, on glucose homeostasis in obese subjects. CO, a novel marine oil, contains omega-3 fatty acid wax esters as well as plant sterols and astaxanthin. In the double-blind, randomized, placebo-controlled 12-week intervention study, 266 subjects with distinct IR phenotypes were assigned to four groups: 2 g CO/day, 4 g CO/day, 2 g CO/day + LI, and placebo. The effect of CO on HOMA index reduction was influenced by the initial (t 0) squared HOMA index (interaction p = 0.011). A post hoc test showed significant improvement with 2 g CO/day + LI (estimated marginal means [EMM] 95% confidence interval [CI]: -0.19 [-0.80-0.41], p = 0.021). Secondary analysis revealed that 4 g CO/day had significant effects in subjects with mild IR (HOMA index 2.5-5.0) (EMM [95% CI]: -0.76 [-1.53-0.03], p = 0.043). CO supplementation improved glucose homeostasis, with effects varying by dose, combination with LI, and IR phenotype.
AB - Obesity increases the risk for insulin resistance (IR) and type-2 diabetes. Lifestyle interventions (LI) and dietary supplementation can help mitigate IR. We investigated the effect of calanus oil (CO) supplementation, combined with LI, on glucose homeostasis in obese subjects. CO, a novel marine oil, contains omega-3 fatty acid wax esters as well as plant sterols and astaxanthin. In the double-blind, randomized, placebo-controlled 12-week intervention study, 266 subjects with distinct IR phenotypes were assigned to four groups: 2 g CO/day, 4 g CO/day, 2 g CO/day + LI, and placebo. The effect of CO on HOMA index reduction was influenced by the initial (t 0) squared HOMA index (interaction p = 0.011). A post hoc test showed significant improvement with 2 g CO/day + LI (estimated marginal means [EMM] 95% confidence interval [CI]: -0.19 [-0.80-0.41], p = 0.021). Secondary analysis revealed that 4 g CO/day had significant effects in subjects with mild IR (HOMA index 2.5-5.0) (EMM [95% CI]: -0.76 [-1.53-0.03], p = 0.043). CO supplementation improved glucose homeostasis, with effects varying by dose, combination with LI, and IR phenotype.
KW - Humans
KW - Insulin Resistance/physiology
KW - Obesity/drug therapy
KW - Female
KW - Double-Blind Method
KW - Male
KW - Middle Aged
KW - Homeostasis/drug effects
KW - Blood Glucose/drug effects
KW - Adult
KW - Dietary Supplements
KW - Life Style
KW - Diabetes Mellitus, Type 2
KW - Fatty Acids, Omega-3/administration & dosage
KW - Animals
KW - lifestyle intervention
KW - calanus firmarchicus
KW - dietary supplements
KW - homeostatic model assessment of insulin resistance
UR - http://www.scopus.com/inward/record.url?scp=105003460969&partnerID=8YFLogxK
U2 - 10.3390/md23040139
DO - 10.3390/md23040139
M3 - Article
C2 - 40278260
VL - 23
JO - Marine drugs
JF - Marine drugs
SN - 1660-3397
IS - 4
M1 - 139
ER -