Details
| Translated title of the contribution | L-Arginine and vascular health |
|---|---|
| Original language | German |
| Pages (from-to) | 515-520 |
| Number of pages | 6 |
| Journal | Medizinische Monatsschrift fur Pharmazeuten |
| Volume | 39 |
| Issue number | 12 |
| Publication status | Published - Dec 2016 |
Abstract
Endothelial dysfunction, characterized by a disturbed vascular NO metabolism, represents a key point in atherogenesis. Modern antiatherogenic therapies improve NO availability within the endothelium. As L-arginine acts as the substrate of endo-thelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation. Actually, L-arginine at appropriate dosage (6-8 g/day) improves endothelial function and lowers blood pressure. However, beneficial efects can only be expected in individuals with pronounced endothelial dysfunction and/or individuals with an absolute (patients with hemodialysis) or relative (patients with elevated ADMA levels) arginine deficiency. Whether L-arginine delays progression of atherosclerotic lesions and lowers cardiovascular morbidity and mortality is unknown.
ASJC Scopus subject areas
- Medicine(all)
- Pharmacology (medical)
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Medizinische Monatsschrift fur Pharmazeuten, Vol. 39, No. 12, 12.2016, p. 515-520.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Bedeutung von L-Arginin für die Gefäßgesundheit
AU - Ströhle, A.
AU - von Bibra, H.
AU - Hahn, A.
N1 - Publisher Copyright: © Deutscher Apotheker Verlag. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016/12
Y1 - 2016/12
N2 - Endothelial dysfunction, characterized by a disturbed vascular NO metabolism, represents a key point in atherogenesis. Modern antiatherogenic therapies improve NO availability within the endothelium. As L-arginine acts as the substrate of endo-thelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation. Actually, L-arginine at appropriate dosage (6-8 g/day) improves endothelial function and lowers blood pressure. However, beneficial efects can only be expected in individuals with pronounced endothelial dysfunction and/or individuals with an absolute (patients with hemodialysis) or relative (patients with elevated ADMA levels) arginine deficiency. Whether L-arginine delays progression of atherosclerotic lesions and lowers cardiovascular morbidity and mortality is unknown.
AB - Endothelial dysfunction, characterized by a disturbed vascular NO metabolism, represents a key point in atherogenesis. Modern antiatherogenic therapies improve NO availability within the endothelium. As L-arginine acts as the substrate of endo-thelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation. Actually, L-arginine at appropriate dosage (6-8 g/day) improves endothelial function and lowers blood pressure. However, beneficial efects can only be expected in individuals with pronounced endothelial dysfunction and/or individuals with an absolute (patients with hemodialysis) or relative (patients with elevated ADMA levels) arginine deficiency. Whether L-arginine delays progression of atherosclerotic lesions and lowers cardiovascular morbidity and mortality is unknown.
UR - http://www.scopus.com/inward/record.url?scp=85001090534&partnerID=8YFLogxK
M3 - Artikel
VL - 39
SP - 515
EP - 520
JO - Medizinische Monatsschrift fur Pharmazeuten
JF - Medizinische Monatsschrift fur Pharmazeuten
SN - 0342-9601
IS - 12
ER -