Details
| Original language | English |
|---|---|
| Pages (from-to) | 615-619 |
| Number of pages | 5 |
| Journal | Therapeutic Innovation & Regulatory Science |
| Volume | 31 |
| Issue number | 2 |
| Publication status | Published - 30 Dec 1997 |
Abstract
A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held March 25–27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper describes the application of adaptive interim analysis in pharmacological studies. Bauer and Köhne (1) published a two-step approach in the case of unknown a priori information. This approach is now widely used for clinical trails. Here, the advantages of use in some pharmacological studies will be discussed.
Keywords
- Interim analysis, Pharmacological studies
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Medicine(all)
- Pharmacology (medical)
Sustainable Development Goals
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In: Therapeutic Innovation & Regulatory Science, Vol. 31, No. 2, 30.12.1997, p. 615-619.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Application of adaptive interim analysis in pharmacology
AU - Hothorn, Ludwig A.
AU - Martin, Ullrich
PY - 1997/12/30
Y1 - 1997/12/30
N2 - A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held March 25–27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper describes the application of adaptive interim analysis in pharmacological studies. Bauer and Köhne (1) published a two-step approach in the case of unknown a priori information. This approach is now widely used for clinical trails. Here, the advantages of use in some pharmacological studies will be discussed.
AB - A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held March 25–27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper describes the application of adaptive interim analysis in pharmacological studies. Bauer and Köhne (1) published a two-step approach in the case of unknown a priori information. This approach is now widely used for clinical trails. Here, the advantages of use in some pharmacological studies will be discussed.
KW - Interim analysis
KW - Pharmacological studies
UR - http://www.scopus.com/inward/record.url?scp=84993825048&partnerID=8YFLogxK
U2 - 10.1177/009286159703100229
DO - 10.1177/009286159703100229
M3 - Article
AN - SCOPUS:84993825048
VL - 31
SP - 615
EP - 619
JO - Therapeutic Innovation & Regulatory Science
JF - Therapeutic Innovation & Regulatory Science
SN - 2168-4790
IS - 2
ER -