Details
| Original language | English |
|---|---|
| Article number | 100260 |
| Journal | Journal of Trace Elements and Minerals |
| Volume | 14 |
| Early online date | 24 Aug 2025 |
| Publication status | Published - Dec 2025 |
Abstract
Background: Obesity and overweight result in low-grade systemic inflammation associated with an increase of oxidative stress and hepcidin discharging and lowering iron absorption giving rise to anemia. This study is aimed to investigate the anti-anemic effect of cerium oxide nanoparticles (CeO 2NPs) in obese rats via investigation of hepcidin expression, ferritin, inflammatory markers, and oxidative stress parameters Methods: CeO 2NPs were synthesized using sol–gel method. Eight male rats were specified as control non-obese. Twenty-four Wistar adult male rats were subjected to high fat diet /sucrose and they were divided into 3 groups; obese, 15 or 30 mg.kg −1 CeO 2NPs IP treatment for the subsequent 8 weeks. Blood cell counts, hepicidin gene expression in adipose tissue, inflammatory and oxidative stress parameters beside iron parameters were evaluated in the experimental groups. Results: CeO 2NPs crystallite size is 48.88 nm. The ratio of Ce 4+ was 69.33 %. The intraperitoneal injection of obese rats with CeO 2NPs substantially reduced the elevetion in WBCs, platelets count, plasma cholesterol, triglycerides, malondialdehyde (MDA), superoxide dismutase (SOD), TNF-α (Tumor necrosis factor alpha), IL-6 (Interleukin-6), and CRP (C-reactive protein) levels. Also, CeO 2NPs combate the increase of hepcidin gene expression, ferritin level, iron content in adipose tissue, body weight, body mass index (BMI) and plasma leptin concentration of obese rats. Moreover, RBCs and WBCs count, Hb level, adiponectin level, and reduced glutathione (GSH) were enhanced in obese rats given CeO 2NPs. Conclusion: CeO 2NPs may have anti-anemic activity in obese rats via management of hepcidin gene expression along with antioxidant and anti-inflammatory properties.
Keywords
- BMI, CeO NPs, Hepcidin gene expression, Iron overload, Obesity, Oxidative stress
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Toxicology
Sustainable Development Goals
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In: Journal of Trace Elements and Minerals, Vol. 14, 100260, 12.2025.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Anti-Anemic Potential of Cerium Oxide Nanoparticles in Diet-Induced Obese Rats: Role of Hepcidin, Oxidative Stress, and Inflammation
AU - Bashandy, Samir AE
AU - AElbaset, Marawan
AU - Ibrahim, Fatma A.A.
AU - Moussa, Sherif A. Abdelmottaleb
AU - El-Latif, Noha A. Abd
AU - Afifi, Sherif M.
AU - Esatbeyoglu, Tuba
AU - El-Seidy, Ahmed M.A.
N1 - Publisher Copyright: © 2025 The Author(s)
PY - 2025/12
Y1 - 2025/12
N2 - Background: Obesity and overweight result in low-grade systemic inflammation associated with an increase of oxidative stress and hepcidin discharging and lowering iron absorption giving rise to anemia. This study is aimed to investigate the anti-anemic effect of cerium oxide nanoparticles (CeO 2NPs) in obese rats via investigation of hepcidin expression, ferritin, inflammatory markers, and oxidative stress parameters Methods: CeO 2NPs were synthesized using sol–gel method. Eight male rats were specified as control non-obese. Twenty-four Wistar adult male rats were subjected to high fat diet /sucrose and they were divided into 3 groups; obese, 15 or 30 mg.kg −1 CeO 2NPs IP treatment for the subsequent 8 weeks. Blood cell counts, hepicidin gene expression in adipose tissue, inflammatory and oxidative stress parameters beside iron parameters were evaluated in the experimental groups. Results: CeO 2NPs crystallite size is 48.88 nm. The ratio of Ce 4+ was 69.33 %. The intraperitoneal injection of obese rats with CeO 2NPs substantially reduced the elevetion in WBCs, platelets count, plasma cholesterol, triglycerides, malondialdehyde (MDA), superoxide dismutase (SOD), TNF-α (Tumor necrosis factor alpha), IL-6 (Interleukin-6), and CRP (C-reactive protein) levels. Also, CeO 2NPs combate the increase of hepcidin gene expression, ferritin level, iron content in adipose tissue, body weight, body mass index (BMI) and plasma leptin concentration of obese rats. Moreover, RBCs and WBCs count, Hb level, adiponectin level, and reduced glutathione (GSH) were enhanced in obese rats given CeO 2NPs. Conclusion: CeO 2NPs may have anti-anemic activity in obese rats via management of hepcidin gene expression along with antioxidant and anti-inflammatory properties.
AB - Background: Obesity and overweight result in low-grade systemic inflammation associated with an increase of oxidative stress and hepcidin discharging and lowering iron absorption giving rise to anemia. This study is aimed to investigate the anti-anemic effect of cerium oxide nanoparticles (CeO 2NPs) in obese rats via investigation of hepcidin expression, ferritin, inflammatory markers, and oxidative stress parameters Methods: CeO 2NPs were synthesized using sol–gel method. Eight male rats were specified as control non-obese. Twenty-four Wistar adult male rats were subjected to high fat diet /sucrose and they were divided into 3 groups; obese, 15 or 30 mg.kg −1 CeO 2NPs IP treatment for the subsequent 8 weeks. Blood cell counts, hepicidin gene expression in adipose tissue, inflammatory and oxidative stress parameters beside iron parameters were evaluated in the experimental groups. Results: CeO 2NPs crystallite size is 48.88 nm. The ratio of Ce 4+ was 69.33 %. The intraperitoneal injection of obese rats with CeO 2NPs substantially reduced the elevetion in WBCs, platelets count, plasma cholesterol, triglycerides, malondialdehyde (MDA), superoxide dismutase (SOD), TNF-α (Tumor necrosis factor alpha), IL-6 (Interleukin-6), and CRP (C-reactive protein) levels. Also, CeO 2NPs combate the increase of hepcidin gene expression, ferritin level, iron content in adipose tissue, body weight, body mass index (BMI) and plasma leptin concentration of obese rats. Moreover, RBCs and WBCs count, Hb level, adiponectin level, and reduced glutathione (GSH) were enhanced in obese rats given CeO 2NPs. Conclusion: CeO 2NPs may have anti-anemic activity in obese rats via management of hepcidin gene expression along with antioxidant and anti-inflammatory properties.
KW - BMI
KW - CeO NPs
KW - Hepcidin gene expression
KW - Iron overload
KW - Obesity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=105014817222&partnerID=8YFLogxK
U2 - 10.1016/j.jtemin.2025.100260
DO - 10.1016/j.jtemin.2025.100260
M3 - Article
VL - 14
JO - Journal of Trace Elements and Minerals
JF - Journal of Trace Elements and Minerals
M1 - 100260
ER -