The aim of the cooperation project MiniLAB is the development of a portable instrument for fast on-site monitoring and detection of pollutants in water based on nano high performance liquid chromatography (nano-HPLC) and electrospray ionization (ESI) ion mobility spectrometry (IMS). The main tasks of the subproject are the realization of a high voltage isolated data acquisition as well as the control of the ESI parameters during a run of a solvent gradient.