TY - JOUR

T1 - Two new labdane diterpenoids and one new β-lactam from the aerial parts of Roylea cinerea

AU - Sharma, Reena

AU - Mohammadi-Ostad-Kalayeh, Sona

AU - Stahl, Frank

AU - Zeilinger, Carsten

AU - Dräger, Gerald

AU - Kirschning, Andreas

AU - Ravikumar, P. C.

N1 - Funding Information: We acknowledge the AMRC instrumental facilities at IIT Mandi and the instrumental facilities at Leibniz Universität Hannover. PCR is thankful for financial assistance in the form of SEED Grant by IIT Mandi and DST (Sr/FT/CS-92/2011). RS is thankful to Department of Science and Technology, New Delhi and IIT Mandi for financial assistance and DAAD for funding short-term academic visit to Institute of Organic Chemistry and Centre of Biomolecular Drug Research (BMWZ), Leibniz Universität Hannover, Germany. Dr. J. Fohrer, Ms. Monika Rettstadt, Ms. Dagmar Körtje and Mr. Sunil Kumar are highly acknowledged for recording the NMR spectra. Authors are thankful to D. Rambabu for help in solving the crystal structure. Prateep S. Sagara and Ashish Bahuguna are acknowledged for their helpful discussions in solving the NMR spectra. We are also thankful to Dr. Ian Beadham, Kingston University for his help in improving this manuscript.

PY - 2017/3

Y1 - 2017/3

N2 - Two new labdane diterpenoids cinereanoid C (1), cinereanoid D (2), a new β-lactam, cinerealactam E (3) as well as six known flavonoid glycosides (4–9) were isolated from the aerial parts of Roylea cinerea (Lamiaceae). The structures of (1–9) were all determined by MS, IR and NMR spectroscopy. The structure of cinereanoid D (2) was further proven by single crystal X-ray diffraction. Six known flavonoid glycosides (4–9) were also isolated for the first time from this plant. 2, 5, 6 and 7 were found to significantly inhibit the ATP binding of a tumour growth-promoting heat shock protein, Hsp90.

AB - Two new labdane diterpenoids cinereanoid C (1), cinereanoid D (2), a new β-lactam, cinerealactam E (3) as well as six known flavonoid glycosides (4–9) were isolated from the aerial parts of Roylea cinerea (Lamiaceae). The structures of (1–9) were all determined by MS, IR and NMR spectroscopy. The structure of cinereanoid D (2) was further proven by single crystal X-ray diffraction. Six known flavonoid glycosides (4–9) were also isolated for the first time from this plant. 2, 5, 6 and 7 were found to significantly inhibit the ATP binding of a tumour growth-promoting heat shock protein, Hsp90.

KW - Diterpenoids

KW - Labdanes

KW - β Lactam

UR - http://www.scopus.com/inward/record.url?scp=85006365318&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2016.12.013

DO - 10.1016/j.phytol.2016.12.013

M3 - Article

AN - SCOPUS:85006365318

VL - 19

SP - 101

EP - 107

JO - Phytochemistry Letters

JF - Phytochemistry Letters

SN - 1874-3900

ER -