Total synthesis of (+)-ratjadone

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Mathias Christmann
  • Ulhas Bhatt
  • Monika Quitschalle
  • Eckhard Claus
  • Markus Kalesse

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Details

OriginalspracheEnglisch
Seiten (von - bis)4364-4366
Seitenumfang3
FachzeitschriftAngewandte Chemie - International Edition
Jahrgang39
Ausgabenummer23
PublikationsstatusVeröffentlicht - 4 Dez. 2000

Abstract

The coupling of three fragmeats by a wittig olefination and a subsequent selective Heck reaction are the pivotal steps in the the first total synthesis of ratjadone (see picture), a cytotoxic as well as antibiotically effective polyketide. This synthesis enabled the elucidation of the absolute configuration of the natural product. In this way it should also be possible to synthesize structural analogues with which the various cellular processes mediated by ratjadone can be studied.

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Total synthesis of (+)-ratjadone. / Christmann, Mathias; Bhatt, Ulhas; Quitschalle, Monika et al.
in: Angewandte Chemie - International Edition, Jahrgang 39, Nr. 23, 04.12.2000, S. 4364-4366.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Christmann M, Bhatt U, Quitschalle M, Claus E, Kalesse M. Total synthesis of (+)-ratjadone. Angewandte Chemie - International Edition. 2000 Dez 4;39(23):4364-4366. doi: 10.1002/1521-3773(20001201)39:23<4364::AID-ANIE4364>3.0.CO;2-G
Christmann, Mathias ; Bhatt, Ulhas ; Quitschalle, Monika et al. / Total synthesis of (+)-ratjadone. in: Angewandte Chemie - International Edition. 2000 ; Jahrgang 39, Nr. 23. S. 4364-4366.
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