Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 100235 |
| Fachzeitschrift | Endocrine and Metabolic Science |
| Jahrgang | 18 |
| Frühes Online-Datum | 31 März 2025 |
| Publikationsstatus | Veröffentlicht - Juni 2025 |
Abstract
Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Endokrinologie, Diabetes und Stoffwechsel
- Biochemie, Genetik und Molekularbiologie (insg.)
- Endokrinologie
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in: Endocrine and Metabolic Science, Jahrgang 18, 100235, 06.2025.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats
AU - Abdelmottaleb Moussa, Sherif A.
AU - Ibrahim, Fatma A.A.
AU - Elbaset, Marawan Abd
AU - Morsy, Fatma A.
AU - Aziz, Samir W.
AU - Abd El-Latif, Noha A.
AU - Afifi, Sherif M.
AU - Esatbeyoglu, Tuba
AU - El Toumy, Sayed A.
AU - Salib, Josline Y.
AU - Bashandy, Samir A.E.
N1 - Publisher Copyright: © 2025 The Authors
PY - 2025/6
Y1 - 2025/6
N2 - Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.
AB - Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.
KW - Insulin resistance
KW - Liver
KW - Obesity
KW - Oxidative stress
KW - Thyme
UR - http://www.scopus.com/inward/record.url?scp=105001878624&partnerID=8YFLogxK
U2 - 10.1016/j.endmts.2025.100235
DO - 10.1016/j.endmts.2025.100235
M3 - Article
AN - SCOPUS:105001878624
VL - 18
JO - Endocrine and Metabolic Science
JF - Endocrine and Metabolic Science
M1 - 100235
ER -