The interrelation of scientific, ethical, and translational challenges for precision medicine with multimodal biomarkers: A qualitative expert interview study in dermatology research

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • Nora Hangel
  • Alena Buyx
  • Marie Christine Fritzsche

Externe Organisationen

  • Technische Universität München (TUM)
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Aufsatznummere31723
Seitenumfang13
FachzeitschriftHeliyon
Jahrgang10
Ausgabenummer13
Frühes Online-Datum24 Juni 2024
PublikationsstatusVeröffentlicht - 15 Juli 2024

Abstract

This qualitative study examines the impact of scientific, ethical, and translational challenges of precision medicine for atopic dermatitis and psoriasis. The study explores how these challenges affect biomarker research for inflammatory skin diseases as identified by stakeholders, including patient board representatives, pharmaceutical industry partners, and postdoctoral and senior researchers from multiple disciplines in biomarker research. We recruited participating experts both within and associated with the international Biomarkers in Atopic Dermatitis and Psoriasis (BIOMAP) consortium to ensure representation of the different organizational units of the consortium. For the study, we followed the COREQ checklist. The interviews were conducted using GDPR-safe online platforms and the pseudonymized transcripts were analyzed using Atlas.ti. We analyzed the interviews from participants' personal experiences, topic-oriented, and group specific to identify the main themes presented in this article. The findings were presented to peers and to the wider BIOMAP audience, discussed, and a draft was circulated within the consortium for feedback. In this study, we identify and discuss the interrelation of challenges that are relevant to improving precision medicine with multimodal biomarkers. We show how scientific challenges can interrelate with ethical and translational issues, and explain these interdependencies and articulate epistemic and social factors of interdisciplinary collaboration. Based on our findings, we suggest that including patient representatives’ perspectives is crucial for highly interrelated and widely diverse research. The proposed integrative perspective is beneficial for all involved stakeholders. Effective communication of science requires reflection on the tension between scientific uncertainty and the goals of precision medicine. Furthermore, we show how changing the perception of the diseases, atopic dermatitis, and psoriasis can benefit patients beyond medical practice.

ASJC Scopus Sachgebiete

Zitieren

The interrelation of scientific, ethical, and translational challenges for precision medicine with multimodal biomarkers: A qualitative expert interview study in dermatology research. / Hangel, Nora; Buyx, Alena; Fritzsche, Marie Christine.
in: Heliyon, Jahrgang 10, Nr. 13, e31723, 15.07.2024.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Hangel N, Buyx A, Fritzsche MC. The interrelation of scientific, ethical, and translational challenges for precision medicine with multimodal biomarkers: A qualitative expert interview study in dermatology research. Heliyon. 2024 Jul 15;10(13):e31723. Epub 2024 Jun 24. doi: 10.1016/j.heliyon.2024.e31723
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AU - Buyx, Alena

AU - Fritzsche, Marie Christine

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