Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Nickolai I. Klyui
  • Volodymyr S. Chornyi
  • Igor V. Zatovsky
  • Liana I. Tsabiy
  • Alexander A. Buryanov
  • Volodymyr V. Protsenko
  • Volodymyr P. Temchenko
  • Valeriy A. Skryshevsky
  • Birgit Glasmacher
  • Oleksandr Gryshkov

Organisationseinheiten

Externe Organisationen

  • BKT Implant Ltd.
  • Institute of Semiconductors Physics National Academy of Sciences in Ukraine
  • Jilin University
  • ATC-EU Ltd.
  • Litvinenko L.M. Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine
  • Kyiv National Taras Shevchenko University
  • Bogomolets National Medical University (NMU)
  • NIFE- Niedersächsisches Zentrum für Biomedizintechnik, Implantatforschung und Entwicklung
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)25425-25439
Seitenumfang15
FachzeitschriftCeramics international
Jahrgang47
Ausgabenummer18
Frühes Online-Datum29 Mai 2021
PublikationsstatusVeröffentlicht - 15 Sept. 2021

Abstract

An optimal performance of bone implants with bioceramic coatings is closely related to the surface modification technology. For the first time, we have evaluated a gas detonation deposition (GDD) approach to obtain biocompatible ceramic coatings based on bioglass (BG) and calcium phosphates on Ti-based alloys as prospective materials towards their application for the development of bone implants. For the production of the coatings, hydroxyapatite (HA), HA metal-substituted (containing Ag+, Cu2+, or Zn2+) and tricalcium phosphate (TCP) were synthesized and characterized. Pure powders and their combination with BG were used to obtain coatings on a Ti–6Al–4V alloy using the developed automatized GDD setup. The microstructure, phase and chemical composition of the produced coatings were studied using XRD, SEM-EDS and Raman spectroscopy. The produced coated materials were evaluated in vivo in Wistar rats to analyze a reparative osteogenesis over a period of 12 weeks. The results regarding the optimization of the GDD method indicate its high productivity, as confirmed by high deposition rates. The highest deposition rate was observed for the coatings obtained from the HA metal-substituted powders. The results revealed a partial transformation of a HA phase to an α-TCP phase during the deposition, with a prevalence of the HA-phase in the coatings. According to the histological evaluation, the reparative osteogenesis occurs through the perimeter of the titanium implants, whereas the regeneration level increases from the 4th to the 12th week. The highest osteointegration level was detected for the implants coated with a biocomposite consisting of BG, HA and TCP. The results of the current study demonstrate an effectiveness of the GDD method to produce biocompatible coatings on Ti-based alloys. This provides excellent prerequisites towards the application and standardization of the GDD technology to manufacture bone implants for bone fixation and defect replacement, as well as the development of dental implants.

ASJC Scopus Sachgebiete

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Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement. / Klyui, Nickolai I.; Chornyi, Volodymyr S.; Zatovsky, Igor V. et al.
in: Ceramics international, Jahrgang 47, Nr. 18, 15.09.2021, S. 25425-25439.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Klyui, NI, Chornyi, VS, Zatovsky, IV, Tsabiy, LI, Buryanov, AA, Protsenko, VV, Temchenko, VP, Skryshevsky, VA, Glasmacher, B & Gryshkov, O 2021, 'Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement', Ceramics international, Jg. 47, Nr. 18, S. 25425-25439. https://doi.org/10.1016/j.ceramint.2021.05.265
Klyui, N. I., Chornyi, V. S., Zatovsky, I. V., Tsabiy, L. I., Buryanov, A. A., Protsenko, V. V., Temchenko, V. P., Skryshevsky, V. A., Glasmacher, B., & Gryshkov, O. (2021). Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement. Ceramics international, 47(18), 25425-25439. https://doi.org/10.1016/j.ceramint.2021.05.265
Klyui NI, Chornyi VS, Zatovsky IV, Tsabiy LI, Buryanov AA, Protsenko VV et al. Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement. Ceramics international. 2021 Sep 15;47(18):25425-25439. Epub 2021 Mai 29. doi: 10.1016/j.ceramint.2021.05.265
Klyui, Nickolai I. ; Chornyi, Volodymyr S. ; Zatovsky, Igor V. et al. / Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement. in: Ceramics international. 2021 ; Jahrgang 47, Nr. 18. S. 25425-25439.
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title = "Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement",
abstract = "An optimal performance of bone implants with bioceramic coatings is closely related to the surface modification technology. For the first time, we have evaluated a gas detonation deposition (GDD) approach to obtain biocompatible ceramic coatings based on bioglass (BG) and calcium phosphates on Ti-based alloys as prospective materials towards their application for the development of bone implants. For the production of the coatings, hydroxyapatite (HA), HA metal-substituted (containing Ag+, Cu2+, or Zn2+) and tricalcium phosphate (TCP) were synthesized and characterized. Pure powders and their combination with BG were used to obtain coatings on a Ti–6Al–4V alloy using the developed automatized GDD setup. The microstructure, phase and chemical composition of the produced coatings were studied using XRD, SEM-EDS and Raman spectroscopy. The produced coated materials were evaluated in vivo in Wistar rats to analyze a reparative osteogenesis over a period of 12 weeks. The results regarding the optimization of the GDD method indicate its high productivity, as confirmed by high deposition rates. The highest deposition rate was observed for the coatings obtained from the HA metal-substituted powders. The results revealed a partial transformation of a HA phase to an α-TCP phase during the deposition, with a prevalence of the HA-phase in the coatings. According to the histological evaluation, the reparative osteogenesis occurs through the perimeter of the titanium implants, whereas the regeneration level increases from the 4th to the 12th week. The highest osteointegration level was detected for the implants coated with a biocomposite consisting of BG, HA and TCP. The results of the current study demonstrate an effectiveness of the GDD method to produce biocompatible coatings on Ti-based alloys. This provides excellent prerequisites towards the application and standardization of the GDD technology to manufacture bone implants for bone fixation and defect replacement, as well as the development of dental implants.",
keywords = "Bioceramics, Biomedical applications (E), Calcium phosphate, Coatings (A), Composites (B), Synthesis of powders (A)",
author = "Klyui, {Nickolai I.} and Chornyi, {Volodymyr S.} and Zatovsky, {Igor V.} and Tsabiy, {Liana I.} and Buryanov, {Alexander A.} and Protsenko, {Volodymyr V.} and Temchenko, {Volodymyr P.} and Skryshevsky, {Valeriy A.} and Birgit Glasmacher and Oleksandr Gryshkov",
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TY - JOUR

T1 - Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement

AU - Klyui, Nickolai I.

AU - Chornyi, Volodymyr S.

AU - Zatovsky, Igor V.

AU - Tsabiy, Liana I.

AU - Buryanov, Alexander A.

AU - Protsenko, Volodymyr V.

AU - Temchenko, Volodymyr P.

AU - Skryshevsky, Valeriy A.

AU - Glasmacher, Birgit

AU - Gryshkov, Oleksandr

N1 - Funding Information: The work was supported by the joint German-Ukrainian project “MagicCoat” ( Bundesministerium für Bildung und Forschung № 01DK20016 , Ministry of Education and Science of Ukraine № M/138–2019 ), and the national long-term project № WQ20142200205 (Recruitment Program of Global Experts, PRC). The authors are grateful to Sven-Alexander Barker for language editing and final proof-reading, to Dr. Volodymyr Lozinski for assistance with the EDS measurements, as well as Mykhailo Dusheiko and Tomash Sabov for the profilometry investigations.

PY - 2021/9/15

Y1 - 2021/9/15

N2 - An optimal performance of bone implants with bioceramic coatings is closely related to the surface modification technology. For the first time, we have evaluated a gas detonation deposition (GDD) approach to obtain biocompatible ceramic coatings based on bioglass (BG) and calcium phosphates on Ti-based alloys as prospective materials towards their application for the development of bone implants. For the production of the coatings, hydroxyapatite (HA), HA metal-substituted (containing Ag+, Cu2+, or Zn2+) and tricalcium phosphate (TCP) were synthesized and characterized. Pure powders and their combination with BG were used to obtain coatings on a Ti–6Al–4V alloy using the developed automatized GDD setup. The microstructure, phase and chemical composition of the produced coatings were studied using XRD, SEM-EDS and Raman spectroscopy. The produced coated materials were evaluated in vivo in Wistar rats to analyze a reparative osteogenesis over a period of 12 weeks. The results regarding the optimization of the GDD method indicate its high productivity, as confirmed by high deposition rates. The highest deposition rate was observed for the coatings obtained from the HA metal-substituted powders. The results revealed a partial transformation of a HA phase to an α-TCP phase during the deposition, with a prevalence of the HA-phase in the coatings. According to the histological evaluation, the reparative osteogenesis occurs through the perimeter of the titanium implants, whereas the regeneration level increases from the 4th to the 12th week. The highest osteointegration level was detected for the implants coated with a biocomposite consisting of BG, HA and TCP. The results of the current study demonstrate an effectiveness of the GDD method to produce biocompatible coatings on Ti-based alloys. This provides excellent prerequisites towards the application and standardization of the GDD technology to manufacture bone implants for bone fixation and defect replacement, as well as the development of dental implants.

AB - An optimal performance of bone implants with bioceramic coatings is closely related to the surface modification technology. For the first time, we have evaluated a gas detonation deposition (GDD) approach to obtain biocompatible ceramic coatings based on bioglass (BG) and calcium phosphates on Ti-based alloys as prospective materials towards their application for the development of bone implants. For the production of the coatings, hydroxyapatite (HA), HA metal-substituted (containing Ag+, Cu2+, or Zn2+) and tricalcium phosphate (TCP) were synthesized and characterized. Pure powders and their combination with BG were used to obtain coatings on a Ti–6Al–4V alloy using the developed automatized GDD setup. The microstructure, phase and chemical composition of the produced coatings were studied using XRD, SEM-EDS and Raman spectroscopy. The produced coated materials were evaluated in vivo in Wistar rats to analyze a reparative osteogenesis over a period of 12 weeks. The results regarding the optimization of the GDD method indicate its high productivity, as confirmed by high deposition rates. The highest deposition rate was observed for the coatings obtained from the HA metal-substituted powders. The results revealed a partial transformation of a HA phase to an α-TCP phase during the deposition, with a prevalence of the HA-phase in the coatings. According to the histological evaluation, the reparative osteogenesis occurs through the perimeter of the titanium implants, whereas the regeneration level increases from the 4th to the 12th week. The highest osteointegration level was detected for the implants coated with a biocomposite consisting of BG, HA and TCP. The results of the current study demonstrate an effectiveness of the GDD method to produce biocompatible coatings on Ti-based alloys. This provides excellent prerequisites towards the application and standardization of the GDD technology to manufacture bone implants for bone fixation and defect replacement, as well as the development of dental implants.

KW - Bioceramics

KW - Biomedical applications (E)

KW - Calcium phosphate

KW - Coatings (A)

KW - Composites (B)

KW - Synthesis of powders (A)

UR - http://www.scopus.com/inward/record.url?scp=85107453016&partnerID=8YFLogxK

U2 - 10.1016/j.ceramint.2021.05.265

DO - 10.1016/j.ceramint.2021.05.265

M3 - Article

AN - SCOPUS:85107453016

VL - 47

SP - 25425

EP - 25439

JO - Ceramics international

JF - Ceramics international

SN - 0272-8842

IS - 18

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