(p)ppGpp: An important player during heat shock response

Publikation: Beitrag in FachzeitschriftÜbersichtsarbeitForschungPeer-Review

Autorschaft

  • Kristina Driller
  • Fabián A. Cornejo
  • Kürşad Turgay

Organisationseinheiten

Externe Organisationen

  • Max-Planck-Forschungsstelle für die Wissenschaft der Pathogene (MPUSP)
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Details

OriginalspracheEnglisch
Aufsatznummeruqad017
FachzeitschriftMicroLife
Jahrgang4
PublikationsstatusVeröffentlicht - 6 Apr. 2023

Abstract

The alarmones and second messengers (p)ppGpp are important for the cellular response to amino acid starvation. Although the stringent response is present in many bacteria, the targets and functions of (p)ppGpp can differ between species, and our knowledge of (p)ppGpp targets is constantly expanding. Recently, it was demonstrated that these alarmones are also part of the heat shock response in Bacillus subtilis and that there is a functional overlap with the oxidative and heat stress transcriptional regulator Spx. Here, the (p)ppGpp second messenger alarmones allow the fast stress-induced downregulation of translation while Spx inhibits the further expression of translation-related genes to lower the load on the protein quality control system, while the chaperone and protease expression is induced. In this review, we discuss the role of (p)ppGpp and its intricate connections in the complex network of stress sensing, heat shock response, and adaptation in B. subtilis cells.

ASJC Scopus Sachgebiete

Zitieren

(p)ppGpp: An important player during heat shock response. / Driller, Kristina; Cornejo, Fabián A.; Turgay, Kürşad.
in: MicroLife, Jahrgang 4, uqad017, 06.04.2023.

Publikation: Beitrag in FachzeitschriftÜbersichtsarbeitForschungPeer-Review

Driller, K, Cornejo, FA & Turgay, K 2023, '(p)ppGpp: An important player during heat shock response', MicroLife, Jg. 4, uqad017. https://doi.org/10.1093/femsml/uqad017
Driller, K., Cornejo, F. A., & Turgay, K. (2023). (p)ppGpp: An important player during heat shock response. MicroLife, 4, Artikel uqad017. https://doi.org/10.1093/femsml/uqad017
Driller K, Cornejo FA, Turgay K. (p)ppGpp: An important player during heat shock response. MicroLife. 2023 Apr 6;4:uqad017. doi: 10.1093/femsml/uqad017
Driller, Kristina ; Cornejo, Fabián A. ; Turgay, Kürşad. / (p)ppGpp : An important player during heat shock response. in: MicroLife. 2023 ; Jahrgang 4.
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AU - Cornejo, Fabián A.

AU - Turgay, Kürşad

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