Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • Denver Linklater
  • Yulia Karlagina
  • Karolinne Martins de Sousa
  • Daniel E. Heath
  • Maxim Radaev
  • Boris N. Chichkov
  • Galina V. Romanova
  • Vadim P. Veiko
  • Elena P. Ivanova

Organisationseinheiten

Externe Organisationen

  • University of Melbourne
  • Royal Melbourne Institute of Technology University
  • St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO)
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Details

OriginalspracheEnglisch
Aufsatznummer105503
Seitenumfang13
FachzeitschriftSurfaces and Interfaces
Jahrgang56
Frühes Online-Datum23 Nov. 2024
PublikationsstatusVeröffentlicht - 1 Jan. 2025

Abstract

Implant surface topography plays an important role in determining cell responses, including attachment, proliferation, migration, and differentiation. With rapid developments in micro-and nano-fabrication methods, precisely controlled patterns can be generated on implant surfaces. Osteon-mimetic structures are of great interest as new surface designs on bone implants for creating optimal conditions for bone tissue growth. In this work, we used a laser ablation technique to create a biomimetic relief on Ti-6Al-4 V supports. The osteon-mimetic reliefs exhibited patterns of concentric lamellae-like rings of different width and periodicity. A distinctive feature of these reliefs is the presence of a highly porous nanocoating of titanium oxides, formed as a result of reverse deposition from the vapor-gas phase during ablation. Our investigation of the response of human mesenchymal stem cells revealed that the osteon-mimetic microrelief topography significantly influenced their adhesion, proliferation, and polarization. The presence of the nanocoating further impacted the number and localization of their focal adhesions. The outcomes of this work demonstrate an innovative direction towards the design of osteon-mimetic topographies on implantable materials. This work also holds the potential to identify optimal combinations of microrelief and nanocoating parameters to elicit specific cellular responses.

ASJC Scopus Sachgebiete

Zitieren

Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth. / Linklater, Denver; Karlagina, Yulia; de Sousa, Karolinne Martins et al.
in: Surfaces and Interfaces, Jahrgang 56, 105503, 01.01.2025.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Linklater, D, Karlagina, Y, de Sousa, KM, Heath, DE, Radaev, M, Chichkov, BN, Romanova, GV, Veiko, VP & Ivanova, EP 2025, 'Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth', Surfaces and Interfaces, Jg. 56, 105503. https://doi.org/10.1016/j.surfin.2024.105503
Linklater, D., Karlagina, Y., de Sousa, K. M., Heath, D. E., Radaev, M., Chichkov, B. N., Romanova, G. V., Veiko, V. P., & Ivanova, E. P. (2025). Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth. Surfaces and Interfaces, 56, Artikel 105503. https://doi.org/10.1016/j.surfin.2024.105503
Linklater D, Karlagina Y, de Sousa KM, Heath DE, Radaev M, Chichkov BN et al. Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth. Surfaces and Interfaces. 2025 Jan 1;56:105503. Epub 2024 Nov 23. doi: 10.1016/j.surfin.2024.105503
Linklater, Denver ; Karlagina, Yulia ; de Sousa, Karolinne Martins et al. / Osteon-mimetic laser-structured Ti-6Al-4V supports for guided stem cell growth. in: Surfaces and Interfaces. 2025 ; Jahrgang 56.
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abstract = "Implant surface topography plays an important role in determining cell responses, including attachment, proliferation, migration, and differentiation. With rapid developments in micro-and nano-fabrication methods, precisely controlled patterns can be generated on implant surfaces. Osteon-mimetic structures are of great interest as new surface designs on bone implants for creating optimal conditions for bone tissue growth. In this work, we used a laser ablation technique to create a biomimetic relief on Ti-6Al-4 V supports. The osteon-mimetic reliefs exhibited patterns of concentric lamellae-like rings of different width and periodicity. A distinctive feature of these reliefs is the presence of a highly porous nanocoating of titanium oxides, formed as a result of reverse deposition from the vapor-gas phase during ablation. Our investigation of the response of human mesenchymal stem cells revealed that the osteon-mimetic microrelief topography significantly influenced their adhesion, proliferation, and polarization. The presence of the nanocoating further impacted the number and localization of their focal adhesions. The outcomes of this work demonstrate an innovative direction towards the design of osteon-mimetic topographies on implantable materials. This work also holds the potential to identify optimal combinations of microrelief and nanocoating parameters to elicit specific cellular responses.",
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AU - Linklater, Denver

AU - Karlagina, Yulia

AU - de Sousa, Karolinne Martins

AU - Heath, Daniel E.

AU - Radaev, Maxim

AU - Chichkov, Boris N.

AU - Romanova, Galina V.

AU - Veiko, Vadim P.

AU - Ivanova, Elena P.

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Y1 - 2025/1/1

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