Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 40-56 |
| Seitenumfang | 17 |
| Fachzeitschrift | European Journal of Pharmaceutics and Biopharmaceutics |
| Jahrgang | 126 |
| Frühes Online-Datum | 19 Mai 2017 |
| Publikationsstatus | Veröffentlicht - Mai 2018 |
Abstract
Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biotechnologie
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Pharmazeutische Wissenschaften
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: European Journal of Pharmaceutics and Biopharmaceutics, Jahrgang 126, 05.2018, S. 40-56.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung
}
TY - JOUR
T1 - Novel strategies for the formulation and processing of poorly water-soluble drugs
AU - Göke, Katrin
AU - Lorenz, Thomas
AU - Repanas, Alexandros
AU - Schneider, Frederic
AU - Steiner, Denise
AU - Baumann, Knut
AU - Bunjes, Heike
AU - Dietzel, Andreas
AU - Finke, Jan H.
AU - Glasmacher, Birgit
AU - Kwade, Arno
N1 - © 2017 Elsevier B.V. All rights reserved.
PY - 2018/5
Y1 - 2018/5
N2 - Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers.
AB - Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in the development process of new drug products. This article provides an overview on some of the current approaches for the formulation of poorly water-soluble drugs with a special focus on strategies pursued at the Center of Pharmaceutical Engineering of the TU Braunschweig. These comprise formulation in lipid-based colloidal drug delivery systems and experimental as well as computational approaches towards the efficient identification of the most suitable carrier systems. For less lipophilic substances the preparation of drug nanoparticles by milling and precipitation is investigated for instance by means of microsystem-based manufacturing techniques and with special regard to the preparation of individualized dosage forms. Another option to overcome issues with poor drug solubility is the incorporation into nanospun fibers.
KW - Colloidal lipid carriers
KW - Computational carrier selection
KW - Drug delivery systems
KW - Drug nanosuspensions
KW - Electrospinning
KW - Microfluidics
KW - Orodispersible films
KW - Solubility
UR - http://www.scopus.com/inward/record.url?scp=85019745302&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2017.05.008
DO - 10.1016/j.ejpb.2017.05.008
M3 - Article
C2 - 28532676
AN - SCOPUS:85019745302
VL - 126
SP - 40
EP - 56
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
SN - 0939-6411
ER -