Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | Multimodal Biomedical Imaging XIX |
| Herausgeber/-innen | Fred S. Azar, Xavier Intes |
| Herausgeber (Verlag) | SPIE |
| Seitenumfang | 6 |
| ISBN (elektronisch) | 9781510669277 |
| Publikationsstatus | Veröffentlicht - 12 März 2024 |
| Veranstaltung | SPIE BiOS 2024 - San Francisco, USA / Vereinigte Staaten Dauer: 27 Jan. 2024 → 1 Feb. 2024 |
Publikationsreihe
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Band | 12834 |
| ISSN (Print) | 1605-7422 |
Abstract
The incidence of skin cancer, including melanoma, has been steadily increasing over the past decades. Early-stage melanoma often exhibits minimal symptoms, making it challenging to detect. However, when it progresses to later stages and spreads to the lymph nodes, the chances of survival significantly decrease. The current diagnostic gold standard involves invasive and time-consuming procedures, such as visual examination, excision, and histological examination of tissue samples. As an alternative, we developed a new multimodal optical system that addresses these challenges by integrating ultrasound (US), photoacoustic tomography (PAT), optical coherence tomography (OCT) and Raman spectroscopy (RS) into a single measurement unit. The optical coherence tomography OCT delivers detailed structural and depth information for thin skin lesions, while US and PAT enable the assessment of penetration depth in thicker lesions, and Raman spectroscopy analyzes the chemical composition of skin lesions, aiding in the differentiation between benign and malignant cases. The US and PAT are seamlessly integrated using an acoustical reflector inside a custom-made water tank, enabling C-mode measurements at the same position as OCT and RS without the need to switch scanning heads. Our system offers a fast and non-invasive approach to measure the dignity and maximal depth of skin lesions, which can help the dermatologists to make informed decisions regarding excision margins. The exemplary imaging capabilities of the presented multimodal setup are demonstrated in vivo on human nevus, which was excised after the measurement. The obtained results are compared with corresponding histological images for comprehensive evaluation.
ASJC Scopus Sachgebiete
- Werkstoffwissenschaften (insg.)
- Elektronische, optische und magnetische Materialien
- Physik und Astronomie (insg.)
- Atom- und Molekularphysik sowie Optik
- Werkstoffwissenschaften (insg.)
- Biomaterialien
- Medizin (insg.)
- Radiologie, Nuklearmedizin und Bildgebung
Ziele für nachhaltige Entwicklung
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Multimodal Biomedical Imaging XIX. Hrsg. / Fred S. Azar; Xavier Intes. SPIE, 2024. 1283408 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Band 12834).
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Aufsatz in Konferenzband › Forschung › Peer-Review
}
TY - GEN
T1 - Non-invasive optical biopsy of skin lesions by multimodal system with OCT, ultrasound, photoacoustics and Raman spectroscopy
AU - Kukk, Anatoly Fedorov
AU - Wu, Di
AU - Panzer, Rüdiger
AU - Emmert, Steffen
AU - Roth, Bernhard
N1 - Publisher Copyright: © 2024 SPIE.
PY - 2024/3/12
Y1 - 2024/3/12
N2 - The incidence of skin cancer, including melanoma, has been steadily increasing over the past decades. Early-stage melanoma often exhibits minimal symptoms, making it challenging to detect. However, when it progresses to later stages and spreads to the lymph nodes, the chances of survival significantly decrease. The current diagnostic gold standard involves invasive and time-consuming procedures, such as visual examination, excision, and histological examination of tissue samples. As an alternative, we developed a new multimodal optical system that addresses these challenges by integrating ultrasound (US), photoacoustic tomography (PAT), optical coherence tomography (OCT) and Raman spectroscopy (RS) into a single measurement unit. The optical coherence tomography OCT delivers detailed structural and depth information for thin skin lesions, while US and PAT enable the assessment of penetration depth in thicker lesions, and Raman spectroscopy analyzes the chemical composition of skin lesions, aiding in the differentiation between benign and malignant cases. The US and PAT are seamlessly integrated using an acoustical reflector inside a custom-made water tank, enabling C-mode measurements at the same position as OCT and RS without the need to switch scanning heads. Our system offers a fast and non-invasive approach to measure the dignity and maximal depth of skin lesions, which can help the dermatologists to make informed decisions regarding excision margins. The exemplary imaging capabilities of the presented multimodal setup are demonstrated in vivo on human nevus, which was excised after the measurement. The obtained results are compared with corresponding histological images for comprehensive evaluation.
AB - The incidence of skin cancer, including melanoma, has been steadily increasing over the past decades. Early-stage melanoma often exhibits minimal symptoms, making it challenging to detect. However, when it progresses to later stages and spreads to the lymph nodes, the chances of survival significantly decrease. The current diagnostic gold standard involves invasive and time-consuming procedures, such as visual examination, excision, and histological examination of tissue samples. As an alternative, we developed a new multimodal optical system that addresses these challenges by integrating ultrasound (US), photoacoustic tomography (PAT), optical coherence tomography (OCT) and Raman spectroscopy (RS) into a single measurement unit. The optical coherence tomography OCT delivers detailed structural and depth information for thin skin lesions, while US and PAT enable the assessment of penetration depth in thicker lesions, and Raman spectroscopy analyzes the chemical composition of skin lesions, aiding in the differentiation between benign and malignant cases. The US and PAT are seamlessly integrated using an acoustical reflector inside a custom-made water tank, enabling C-mode measurements at the same position as OCT and RS without the need to switch scanning heads. Our system offers a fast and non-invasive approach to measure the dignity and maximal depth of skin lesions, which can help the dermatologists to make informed decisions regarding excision margins. The exemplary imaging capabilities of the presented multimodal setup are demonstrated in vivo on human nevus, which was excised after the measurement. The obtained results are compared with corresponding histological images for comprehensive evaluation.
KW - 3D imaging
KW - infiltration depth
KW - multimodal imaging system
KW - optical coherence tomography
KW - photoacoustic tomography
KW - Raman spectroscopy
KW - skin nevi
KW - ultrasound tomography
UR - http://www.scopus.com/inward/record.url?scp=85194375322&partnerID=8YFLogxK
U2 - 10.1117/12.3001918
DO - 10.1117/12.3001918
M3 - Conference contribution
AN - SCOPUS:85194375322
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Multimodal Biomedical Imaging XIX
A2 - Azar, Fred S.
A2 - Intes, Xavier
PB - SPIE
T2 - SPIE BiOS 2024
Y2 - 27 January 2024 through 1 February 2024
ER -