Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1138-1145 |
| Seitenumfang | 8 |
| Fachzeitschrift | Otology and Neurotology |
| Jahrgang | 34 |
| Ausgabenummer | 6 |
| Publikationsstatus | Veröffentlicht - Aug. 2013 |
Abstract
HYPOTHESIS: The present study was performed to examine the impact of the release rate of ciprofloxacin from prostheses coated with nanoporous silica layers on the outcome of an acute bacterial infection of the middle ear of rabbits. BACKGROUND: Middle ear prostheses are often implanted in an infectious environment because of chronic otitis media and cholesteatoma. Bacterial colonization leads to healing disorders after surgery and may lead to the extrusion of the implants. Nanoporous silica layers appear promising as a drug delivery system for antibiotics placed on implants. Before clinical applications can be envisioned, it is necessary to find an optimal release rate. METHODS: White New Zealand rabbits were provided unilaterally with either a "slow release" or a "burst release" ciprofloxacin-containing middle ear Bioverit II prosthesis. After implantation, the middle ears were infected with a solution of Pseudomonas aeruginosa. Afterwards, animals were monitored clinically and, after 3 months, sacrificed to perform necropsy and microbiologic examinations. RESULTS: In the "slow release" group, 7 of 12 animals had to be euthanized preterm because of their poor clinical condition compared with 2 of 12 animals of the "burst release" group (p < 0.05). Clinical and microbiologic examination also showed a better outcome for animals of the burst release group. CONCLUSION: A burst release of ciprofloxacin from middle ear implants is important to combat a perioperative infection with Ps. aeruginosa in the middle ear model of the rabbit.
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Hals-Nasen-Ohrenheilkunde
- Neurowissenschaften (insg.)
- Sensorische Systeme
- Medizin (insg.)
- Klinische Neurologie
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in: Otology and Neurotology, Jahrgang 34, Nr. 6, 08.2013, S. 1138-1145.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Nanoporous silica coatings as a drug delivery system for ciprofloxacin
T2 - Outcome of variable release rates in the infected middle ear of rabbits
AU - Hesse, Daniela
AU - Ehlert, Nina
AU - Lüenhop, Tammo
AU - Smoczek, Anna
AU - Glage, Silke
AU - Behrens, Peter
AU - Müller, Peter Paul
AU - Esser, Karl Heinz
AU - Lenarz, Thomas
AU - Stieve, Martin
AU - Bleich, André
AU - Prenzler, Nils Kristian
PY - 2013/8
Y1 - 2013/8
N2 - HYPOTHESIS: The present study was performed to examine the impact of the release rate of ciprofloxacin from prostheses coated with nanoporous silica layers on the outcome of an acute bacterial infection of the middle ear of rabbits. BACKGROUND: Middle ear prostheses are often implanted in an infectious environment because of chronic otitis media and cholesteatoma. Bacterial colonization leads to healing disorders after surgery and may lead to the extrusion of the implants. Nanoporous silica layers appear promising as a drug delivery system for antibiotics placed on implants. Before clinical applications can be envisioned, it is necessary to find an optimal release rate. METHODS: White New Zealand rabbits were provided unilaterally with either a "slow release" or a "burst release" ciprofloxacin-containing middle ear Bioverit II prosthesis. After implantation, the middle ears were infected with a solution of Pseudomonas aeruginosa. Afterwards, animals were monitored clinically and, after 3 months, sacrificed to perform necropsy and microbiologic examinations. RESULTS: In the "slow release" group, 7 of 12 animals had to be euthanized preterm because of their poor clinical condition compared with 2 of 12 animals of the "burst release" group (p < 0.05). Clinical and microbiologic examination also showed a better outcome for animals of the burst release group. CONCLUSION: A burst release of ciprofloxacin from middle ear implants is important to combat a perioperative infection with Ps. aeruginosa in the middle ear model of the rabbit.
AB - HYPOTHESIS: The present study was performed to examine the impact of the release rate of ciprofloxacin from prostheses coated with nanoporous silica layers on the outcome of an acute bacterial infection of the middle ear of rabbits. BACKGROUND: Middle ear prostheses are often implanted in an infectious environment because of chronic otitis media and cholesteatoma. Bacterial colonization leads to healing disorders after surgery and may lead to the extrusion of the implants. Nanoporous silica layers appear promising as a drug delivery system for antibiotics placed on implants. Before clinical applications can be envisioned, it is necessary to find an optimal release rate. METHODS: White New Zealand rabbits were provided unilaterally with either a "slow release" or a "burst release" ciprofloxacin-containing middle ear Bioverit II prosthesis. After implantation, the middle ears were infected with a solution of Pseudomonas aeruginosa. Afterwards, animals were monitored clinically and, after 3 months, sacrificed to perform necropsy and microbiologic examinations. RESULTS: In the "slow release" group, 7 of 12 animals had to be euthanized preterm because of their poor clinical condition compared with 2 of 12 animals of the "burst release" group (p < 0.05). Clinical and microbiologic examination also showed a better outcome for animals of the burst release group. CONCLUSION: A burst release of ciprofloxacin from middle ear implants is important to combat a perioperative infection with Ps. aeruginosa in the middle ear model of the rabbit.
KW - Drug delivery system
KW - Middle ear prostheses
KW - Nanoporous silica layer
KW - Pseudomonas aeruginosa
KW - Rabbit
UR - http://www.scopus.com/inward/record.url?scp=84881377398&partnerID=8YFLogxK
U2 - 10.1097/MAO.0b013e3182839671
DO - 10.1097/MAO.0b013e3182839671
M3 - Article
C2 - 23598698
AN - SCOPUS:84881377398
VL - 34
SP - 1138
EP - 1145
JO - Otology and Neurotology
JF - Otology and Neurotology
SN - 1531-7129
IS - 6
ER -