Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma

Publikation: Beitrag in Buch/Bericht/Sammelwerk/KonferenzbandAufsatz in KonferenzbandForschungPeer-Review

Autoren

  • Anatoly Fedorov Kukk
  • Di Wu
  • Evelyn Gaffal
  • Rüdiger Panzer
  • Steffen Emmert
  • Bernhard Roth

Externe Organisationen

  • Otto-von-Guericke-Universität Magdeburg
  • Universität Rostock
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Titel des SammelwerksMultimodal Biomedical Imaging XVIII
Herausgeber/-innenFred S. Azar, Xavier Intes, Qianqian Fang
Herausgeber (Verlag)SPIE
ISBN (elektronisch)9781510658479
PublikationsstatusVeröffentlicht - 6 März 2023
VeranstaltungMultimodal Biomedical Imaging XVIII 2023 - San Francisco, USA / Vereinigte Staaten
Dauer: 28 Jan. 20233 Feb. 2023

Publikationsreihe

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Band12371
ISSN (Print)1605-7422

Abstract

The rate of skin cancer incidence including melanoma has been steadily increasing in the last decades. While melanoma often show little to no symptoms in the early stages, they can spread to the lymph nodes and drastically reduce survival chances in the later stages. The current gold standard for diagnosis is visual examination, excision, and histological examination of the sample tissue, which is an invasive, costly and time-consuming process. As an alternative to this procedure, we introduce a novel multimodal optical system that integrates ultrasound (US), photoacoustic tomography (PAT), and optical coherence tomography (OCT) with Raman spectroscopy (RS). The setup allows quick and non-invasive skin lesion diagnosis and the determination of 3D lesion depth, helping the dermatologists make a decision on the excision margins. The OCT delivers structural and depth information of thin skin lesions, while the US and PAT measure the penetration depth of thicker lesions and the RS analyzes the chemical composition that can be used to distinguish between benign and malignant skin lesions. In our setup, the RS and OCT share the optical path and the scanning elements, which allows colocalized measurements. The US and PAT are integrated with an acoustical reflector, which enables B-mode measurements at the same position as OCT and RS without switching the scanning head. We demonstrate the imaging capabilities of the multimodal setup on custom made agar phantoms and present first measurements on ex vivo mouse and in vivo human skin samples. We compare the results with the corresponding histological images.

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Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma. / Kukk, Anatoly Fedorov; Wu, Di; Gaffal, Evelyn et al.
Multimodal Biomedical Imaging XVIII. Hrsg. / Fred S. Azar; Xavier Intes; Qianqian Fang. SPIE, 2023. 1237107 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Band 12371).

Publikation: Beitrag in Buch/Bericht/Sammelwerk/KonferenzbandAufsatz in KonferenzbandForschungPeer-Review

Kukk, AF, Wu, D, Gaffal, E, Panzer, R, Emmert, S & Roth, B 2023, Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma. in FS Azar, X Intes & Q Fang (Hrsg.), Multimodal Biomedical Imaging XVIII., 1237107, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Bd. 12371, SPIE, Multimodal Biomedical Imaging XVIII 2023, San Francisco, USA / Vereinigte Staaten, 28 Jan. 2023. https://doi.org/10.1117/12.2648257
Kukk, A. F., Wu, D., Gaffal, E., Panzer, R., Emmert, S., & Roth, B. (2023). Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma. In F. S. Azar, X. Intes, & Q. Fang (Hrsg.), Multimodal Biomedical Imaging XVIII Artikel 1237107 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Band 12371). SPIE. https://doi.org/10.1117/12.2648257
Kukk AF, Wu D, Gaffal E, Panzer R, Emmert S, Roth B. Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma. in Azar FS, Intes X, Fang Q, Hrsg., Multimodal Biomedical Imaging XVIII. SPIE. 2023. 1237107. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2648257
Kukk, Anatoly Fedorov ; Wu, Di ; Gaffal, Evelyn et al. / Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma. Multimodal Biomedical Imaging XVIII. Hrsg. / Fred S. Azar ; Xavier Intes ; Qianqian Fang. SPIE, 2023. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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title = "Multimodal imaging system with ultrasound, photoacoustics, and optical coherence tomography for optical biopsy of melanoma",
abstract = "The rate of skin cancer incidence including melanoma has been steadily increasing in the last decades. While melanoma often show little to no symptoms in the early stages, they can spread to the lymph nodes and drastically reduce survival chances in the later stages. The current gold standard for diagnosis is visual examination, excision, and histological examination of the sample tissue, which is an invasive, costly and time-consuming process. As an alternative to this procedure, we introduce a novel multimodal optical system that integrates ultrasound (US), photoacoustic tomography (PAT), and optical coherence tomography (OCT) with Raman spectroscopy (RS). The setup allows quick and non-invasive skin lesion diagnosis and the determination of 3D lesion depth, helping the dermatologists make a decision on the excision margins. The OCT delivers structural and depth information of thin skin lesions, while the US and PAT measure the penetration depth of thicker lesions and the RS analyzes the chemical composition that can be used to distinguish between benign and malignant skin lesions. In our setup, the RS and OCT share the optical path and the scanning elements, which allows colocalized measurements. The US and PAT are integrated with an acoustical reflector, which enables B-mode measurements at the same position as OCT and RS without switching the scanning head. We demonstrate the imaging capabilities of the multimodal setup on custom made agar phantoms and present first measurements on ex vivo mouse and in vivo human skin samples. We compare the results with the corresponding histological images.",
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AU - Gaffal, Evelyn

AU - Panzer, Rüdiger

AU - Emmert, Steffen

AU - Roth, Bernhard

N1 - Funding Information: The authors acknowledge financial support from the German Research Foundation DFG (German Research Foundation, Project ID RO 3471/18-1 and EM 63/13-1). Also, financial support from the German Research Foundation (DFG) under Germany’s Excellence Strategy within the Cluster of Excellence PhoenixD (EXC 2122, Project ID 390833453) is acknowledged.

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