Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 46-58 |
| Seitenumfang | 13 |
| Fachzeitschrift | Nutrition research |
| Jahrgang | 140 |
| Frühes Online-Datum | 19 Juni 2025 |
| Publikationsstatus | Veröffentlicht - Aug. 2025 |
Abstract
Aging is associated with chronic low-grade inflammation, while the status of anti-inflammatory (INFLA) micronutrients such as long-chain omega-3 fatty acids (n-3 PUFA), vitamin D, folate, and cobalamin is often low in older people. We hypothesized that n-3 PUFA and certain micronutrients reduce low-grade inflammation in older participants. To test this hypothesis the aim of this randomised, double-blinded, 12-week intervention study involving 112 healthy and physically active older participants (75.6 ± 3.9 years) was to investigate the effect of a multimicronutrient and n-3 PUFA supplementation in physiological doses (i.e., 400 µg folic acid, 100 µg cobalamin, 50 µg cholecalciferol, and 1000 mg eicosapentaenoic acid + docosahexaenoic acid per day) on INFLA biomarkers, which were aggregated in the INFLA score. Dietary intake data were converted into the energy-adjusted dietary inflammatory index (E-DII). A significant increase in the nutrient status biomarkers Omega-3 Index, serum 25-hydroxycholecalciferol, red blood cell folate, and holotranscobalamin was observed in the intervention group compared to the placebo group (all P <.001). In a multiadjusted model (age, sex, body mass index, E-DII, Omega-3 Index), the intervention significantly decreased the INFLA score compared to placebo (P =.036). Participants with a more pro-INFLA E-DII at baseline and higher age showed a greater decrease in the INFLA score than those with a more anti-INFLA E-DII (P =.028) and lower age (P =.043). An effect of multimicronutrient + n-3 PUFA supplementation seems to be more pronounced in older participants with higher age and those with a pro-INFLA background diet. Trial registration: This study is officially recorded in the German Clinical Trials Register (DRKS00021302, registration date: 23.04.2020).
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Endokrinologie, Diabetes und Stoffwechsel
- Biochemie, Genetik und Molekularbiologie (insg.)
- Endokrinologie
- Pflege (insg.)
- Ernährung und Diätetik
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in: Nutrition research, Jahrgang 140, 08.2025, S. 46-58.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Multimicronutrient and omega-3 fatty acid supplementation reduces low-grade inflammation in older participants
T2 - An exploratory study
AU - Kerlikowsky, Felix
AU - Hahn, Andreas
AU - Krüger, Karsten
AU - Schuchardt, Jan Philipp
N1 - Publisher Copyright: © 2025 The Author(s)
PY - 2025/8
Y1 - 2025/8
N2 - Aging is associated with chronic low-grade inflammation, while the status of anti-inflammatory (INFLA) micronutrients such as long-chain omega-3 fatty acids (n-3 PUFA), vitamin D, folate, and cobalamin is often low in older people. We hypothesized that n-3 PUFA and certain micronutrients reduce low-grade inflammation in older participants. To test this hypothesis the aim of this randomised, double-blinded, 12-week intervention study involving 112 healthy and physically active older participants (75.6 ± 3.9 years) was to investigate the effect of a multimicronutrient and n-3 PUFA supplementation in physiological doses (i.e., 400 µg folic acid, 100 µg cobalamin, 50 µg cholecalciferol, and 1000 mg eicosapentaenoic acid + docosahexaenoic acid per day) on INFLA biomarkers, which were aggregated in the INFLA score. Dietary intake data were converted into the energy-adjusted dietary inflammatory index (E-DII). A significant increase in the nutrient status biomarkers Omega-3 Index, serum 25-hydroxycholecalciferol, red blood cell folate, and holotranscobalamin was observed in the intervention group compared to the placebo group (all P <.001). In a multiadjusted model (age, sex, body mass index, E-DII, Omega-3 Index), the intervention significantly decreased the INFLA score compared to placebo (P =.036). Participants with a more pro-INFLA E-DII at baseline and higher age showed a greater decrease in the INFLA score than those with a more anti-INFLA E-DII (P =.028) and lower age (P =.043). An effect of multimicronutrient + n-3 PUFA supplementation seems to be more pronounced in older participants with higher age and those with a pro-INFLA background diet. Trial registration: This study is officially recorded in the German Clinical Trials Register (DRKS00021302, registration date: 23.04.2020).
AB - Aging is associated with chronic low-grade inflammation, while the status of anti-inflammatory (INFLA) micronutrients such as long-chain omega-3 fatty acids (n-3 PUFA), vitamin D, folate, and cobalamin is often low in older people. We hypothesized that n-3 PUFA and certain micronutrients reduce low-grade inflammation in older participants. To test this hypothesis the aim of this randomised, double-blinded, 12-week intervention study involving 112 healthy and physically active older participants (75.6 ± 3.9 years) was to investigate the effect of a multimicronutrient and n-3 PUFA supplementation in physiological doses (i.e., 400 µg folic acid, 100 µg cobalamin, 50 µg cholecalciferol, and 1000 mg eicosapentaenoic acid + docosahexaenoic acid per day) on INFLA biomarkers, which were aggregated in the INFLA score. Dietary intake data were converted into the energy-adjusted dietary inflammatory index (E-DII). A significant increase in the nutrient status biomarkers Omega-3 Index, serum 25-hydroxycholecalciferol, red blood cell folate, and holotranscobalamin was observed in the intervention group compared to the placebo group (all P <.001). In a multiadjusted model (age, sex, body mass index, E-DII, Omega-3 Index), the intervention significantly decreased the INFLA score compared to placebo (P =.036). Participants with a more pro-INFLA E-DII at baseline and higher age showed a greater decrease in the INFLA score than those with a more anti-INFLA E-DII (P =.028) and lower age (P =.043). An effect of multimicronutrient + n-3 PUFA supplementation seems to be more pronounced in older participants with higher age and those with a pro-INFLA background diet. Trial registration: This study is officially recorded in the German Clinical Trials Register (DRKS00021302, registration date: 23.04.2020).
KW - Healthy aging
KW - Inflammatory score
KW - Low-grade inflammation
KW - Micronutrient supplements
KW - Omega-3-Index
UR - http://www.scopus.com/inward/record.url?scp=105010198403&partnerID=8YFLogxK
U2 - 10.1016/j.nutres.2025.06.005
DO - 10.1016/j.nutres.2025.06.005
M3 - Article
AN - SCOPUS:105010198403
VL - 140
SP - 46
EP - 58
JO - Nutrition research
JF - Nutrition research
SN - 0271-5317
ER -