Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 2062 |
| Fachzeitschrift | Polymers |
| Jahrgang | 11 |
| Ausgabenummer | 12 |
| Frühes Online-Datum | 11 Dez. 2019 |
| Publikationsstatus | Veröffentlicht - Dez. 2019 |
Abstract
Electrospun fiber scaffolds are gaining in importance in the area of tissue engineering. They can be used, for example, to fabricate graded implants to mimic the tendon bone junction. For the grading of the tensile strength of the fiber scaffolds, the orientation of the fibers plays a major role. This is currently measured by hand in scanning electron microscope (SEM) images. In this work, a correlation between polarimetric information generated by measuring the Mueller matrix (MM) and the orientation of the fibers of electrospun fiber scaffolds is reported. For this, the MM of fiber scaffolds, which were manufactured with different production parameters, was measured and analyzed. These data were correlated with fiber orientation and mechanical properties, which were evaluated in an established manner. We found that by measurement of the MM the production parameters as well as the relative orientation of the fibers in space can be determined. Thus, the MM measurement is suitable as an alternative tool for non-contact, non-destructive determination of the production parameters and, thus, the degree of alignment of electrospun fiber scaffolds.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Werkstoffwissenschaften (insg.)
- Polymere und Kunststoffe
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in: Polymers, Jahrgang 11, Nr. 12, 2062, 12.2019.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering
AU - Fricke, Dierk
AU - Becker, Alexander
AU - Jütte, Lennart
AU - Bode, Michael
AU - de Cassan, Dominik
AU - Wollweber, Merve
AU - Glasmacher, Birgit
AU - Roth, Bernhard
N1 - Funding information: This project is funded by the Lower Saxony Ministry for Culture and Science (MWK) through the program Tailored Light and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the Cluster of Excellence PhoenixD (EXC 2122, Project ID 390833453). The research project is also supported by the DFG in the framework of the Research Unit 2180. “Graded Implants for Tendon-Bone Junctions”.
PY - 2019/12
Y1 - 2019/12
N2 - Electrospun fiber scaffolds are gaining in importance in the area of tissue engineering. They can be used, for example, to fabricate graded implants to mimic the tendon bone junction. For the grading of the tensile strength of the fiber scaffolds, the orientation of the fibers plays a major role. This is currently measured by hand in scanning electron microscope (SEM) images. In this work, a correlation between polarimetric information generated by measuring the Mueller matrix (MM) and the orientation of the fibers of electrospun fiber scaffolds is reported. For this, the MM of fiber scaffolds, which were manufactured with different production parameters, was measured and analyzed. These data were correlated with fiber orientation and mechanical properties, which were evaluated in an established manner. We found that by measurement of the MM the production parameters as well as the relative orientation of the fibers in space can be determined. Thus, the MM measurement is suitable as an alternative tool for non-contact, non-destructive determination of the production parameters and, thus, the degree of alignment of electrospun fiber scaffolds.
AB - Electrospun fiber scaffolds are gaining in importance in the area of tissue engineering. They can be used, for example, to fabricate graded implants to mimic the tendon bone junction. For the grading of the tensile strength of the fiber scaffolds, the orientation of the fibers plays a major role. This is currently measured by hand in scanning electron microscope (SEM) images. In this work, a correlation between polarimetric information generated by measuring the Mueller matrix (MM) and the orientation of the fibers of electrospun fiber scaffolds is reported. For this, the MM of fiber scaffolds, which were manufactured with different production parameters, was measured and analyzed. These data were correlated with fiber orientation and mechanical properties, which were evaluated in an established manner. We found that by measurement of the MM the production parameters as well as the relative orientation of the fibers in space can be determined. Thus, the MM measurement is suitable as an alternative tool for non-contact, non-destructive determination of the production parameters and, thus, the degree of alignment of electrospun fiber scaffolds.
KW - Electrospinning
KW - Fiber alignment
KW - Mueller matrix
KW - Polycaprolactone
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85079091710&partnerID=8YFLogxK
U2 - 10.3390/polym11122062
DO - 10.3390/polym11122062
M3 - Article
AN - SCOPUS:85079091710
VL - 11
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 12
M1 - 2062
ER -